Search results for "pali"
showing 10 items of 331 documents
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.
2020
Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…
Balancing and clustering of words: a combinatorial analysis of the Burrows & Wheeler Transform
2010
The Burrows-Wheeler Transform (denoted by BWT) is a well founded mathematical transformation on sequences introduced in 1994, widely used in the context of Data Compression and recently studied also from a combinatorial point of view. The transformation does not itself compress the data, but it produces a permutation bwt(w) of an input string w that is easier to compress than the original one, with some fast locally-adaptive algorithms, such as Move-to-Front in combination with Huffman or arithmetic coding. It is well-known that in most real texts, characters with the same or similar contexts tend to be the same. So, the BWT tends to group together characters which occur adjacent to similar…
A natural A/T-rich sequence from the yeast FBP1 gene exists as a cruciform in Escherichia coli cells.
1993
Abstract Palindromic or semipalindromic sequences can adopt cruciform structures in DNA in vitro. It has been demonstrated in some cases that A/T-rich cruciforms exist also in vivo in Escherichia coli. The biological function of those structures is not understood although putative cruciforms have been found in interesting locations on replication origins, operators, or transcriptional termination regions. Here we show by means of the use of structure-dependent nucleases that the 3′ end of the yeast FBP1 gene contains a stable cruciform both in vitro and in E. coli cells and that in both cases, its extrusion depends on the DNA supercoiling state.
Multidisciplinary intervention in the management of breathlessness in people with non-malignant chronic diseases in advanced situation
2018
Resumen El presente trabajo muestra una revisión crítica de un artículo en que se presentan los resultados de un ensayo clínico realizado en un hospital de Reino Unido para estudiar los resultados de una intervención con enfoque paliativo utilizada en el manejo de la disnea en pacientes con enfermedades crónicas en fases avanzadas. Tras el resumen del artículo, destacando los principales resultados obtenidos, se presenta la revisión crítica del artículo, en la que se ha intentado analizar tanto el diseño como la metodología utilizada en el ensayo clínico, como las implicaciones para la práctica de enfermería y especialmente en el ámbito de los cuidados paliativos. Abstract This work shows a…
Informatore Botanico Italiano
2008
The Grotta Grande of Scario (Salerno, Italy): a spot on the archaeology and the environment durino the last interglacial (OIS 5) of the Mediterranean…
2008
La fauna: indagine archeozoologica
2008
Effect of the mineralogical composition on the elastoplastic hydromechanical response of Opalinus Clay shale
2021
Abstract Opalinus Clay is the shale currently under investigation as the host formation for geological radioactive waste disposal in Switzerland. Its hydromechanical response has been widely studied, and the experimental results show a range of values whose dispersion needs to be clarified. This work aims to explain the dispersion in the literature results by correlating the hydro-mechanical response to the mineralogical variability of the tested specimens . Based on published microstructural studies, the Opalinus Clay shale is herein schematised as a sequence of two kinds of layers: the shaly (high in clay-mineral content) and the sandy (low in clay-mineral content) layers. The mineralogic…
1D Compression Behaviour of Opalinus Clay
2017
One of the main concerns related to tunnel excavations, drilling operations and wellbore stability in shales is the generation of excess pore water pressure due to changes in mechanical stress; therefore the consolidation of shales is a fundamental process that must be considered. This paper presents a compre- hensive methodology for analysing the compression and consolidation behaviour of shales. An apparatus to perform high-pressure oedometric tests is presented and an analytical method is introduced to analyse the shale consolidation behaviour, which allows information to be gathered on the coeffi cient of consolidation, stiffness, poroelastic properties, and permeability of the tested m…
Il ruolo della facies sulla resistenza a taglio di argille estremamente consistenti
2022
L’Opalinus Clay Shale è la formazione che ospiterà il deposito profondo di scorie radioattive di alta attività in Svizzera. A causa della sua composizione fortemente eterogenea, tale materiale è stato classificato in diverse facies. Inoltre, esso è caratterizzato da una struttura fissile e da un comportamento idro-meccanico anisotropo. Queste particolari complessità rendono particolarmente difficile la scelta di parametri geomeccanici unici per l’intera formazione. In questa memoria viene presentato uno studio sperimentale mirato alla caratterizzazione del limite inferiore dei parametri di resistenza al taglio, attraverso l’esecuzione di prove di compressione trias siale e prove di taglio a…