Search results for "pan"
showing 10 items of 9912 documents
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract
Vaalirahoituskohu Aamulehden, Helsingin Sanomien ja Keskisuomalaisen pääkirjoituksissa
2011
Tässä tutkielmassa kuvataan, mistä ja miten Aamulehti, Helsingin Sanomat ja Keskisuomalainen kirjoittivat vaalirahoitusta käsittelevissä pääkirjoituksissaan aikavälillä 7.5.2008–17.9.2010. Tutkielmassa kiinnitetään huomiota siihen, mitä aiheita lehdet vaalirahoituksen yhteydessä käsittelivät, keitä toimijoita lehdet nostivat esiin ja mihin lähteisiin nojaten lehdet kirjoittivat pääkirjoituksensa. Tutkielman pääasiallisena tutkimusmenetelmänä on käytetty määrällistä sisällön erittelyä, jonka avulla kirjoitukset on luokiteltu sisältöluokkiin aihe-, toimija- ja lähdeulottuvuuksien mukaan. Tulosten analyysivaiheessa apuna on käytetty laadullista kehysanalyysia. Vaalirahoituskirjoittelun yhteyde…
Relacion de los caudales que han entrado y salido en la Caxa de la Tesorería de este Exército, desde I de Enero Hasta 31 de Diciembre de 1808.
Signat al final: "Como Contador Principal interino=Baltasar Martin" Sign.: [ ]4
Liver and gastrointestinal cancers
2020
Abstract One important limitation in the treatment of liver and gastrointestinal cancers is their poor response to available chemotherapy, which is due in part to efficient mechanisms of defense against antitumor drugs. An important role in chemoresistance is played by ATP-binding cassette (ABC) proteins, normally involved in barrier/secretory functions of the digestive apparatus. ABC pumps, often up-regulated in cancers derived from these organs, actively export antitumor agents from cancer cells, thereby reducing the pharmacological effect of these drugs. Among the ABC proteins with the highest impact on the multidrug resistance (MDR) phenotype of many cancer types is MDR1 or P-glycoprote…
EP1224 Predictors and clinical outcome of pancreatic fistula in patients receiving splenectomy for advanced or recurrent ovarian cancer: a large mult…
2019
Introduction/Background The aim of the surgical treatment of advanced ovarian cancer is to completely remove all macroscopic disease.To achieve optimal cytoreduction, the use of extensive upper abdominal surgery has become widely accepted.Although the disease doesn’t usually invade the splenic parenchyma, the capsule may commonly be infiltrated. These metastases may be difficult to be dissected from the pancreatic tail and a partial pancreatic resection en bloc with spleen may be required. The objective of this study is to evaluate predictors and clinical outcome of pancreatic fistula in patients receiving splenectomy for advanced or recurrent ovarian cancer. Methodology Data of women recei…
Effectiveness and safety of lomitapide in a patient with familial chylomicronemia syndrome
2020
Background: Familial chylomicronemia syndrome (FCS) is characterized by severe fasting hypertriglyceridemia, abdominal pain, and recurrent acute pancreatitis. Available triglyceride-lowering drugs are insufficient to avoid pancreatitis. Therefore, there is a significant unmet medical need for effective triglyceride-lowering drugs for patients with FCS. Case report: We report the second case of a patient with FCS and recurrent pancreatitis treated with lomitapide. Lomitapide treatment resulted in a reduction of fasting TG levels from 2897 mg/dL (32.71 mmol/L) to an average of 954 mg/dL (10.77 mmol/L) on the 30 mg lomitapide equating to a 67% reduction from baseline. After 26 months of lomita…
Severe Gastrointestinal Features in Children with COVID-19: A Multicenter Retrospective Cohort Study
2021
Background: Severe gastrointestinal (GI) involvement has been occasionally reported in children with SARS-CoV-2 infection or among those with multisystem inflammatory syndrome (MIS-C). We aimed to investigate the clinical, radiological and histopathological GI characteristics in order to identify factors associated with severe outcome. Methods: In this multicenter retrospective nationwide cohort study, symptomatic children with laboratory confirmed SARS-CoV-2 infection or MIS-C were enrolled. Children who received a diagnosis of acute abdomen, appendicitis, intussusception, pancreatitis, diffuse adeno-mesenteritis or abdominal fluid collections requiring surgical consultation and temporally…
La single ship company fictive
2017
International audience; Note sous Cour de cassation (com.), 14 juin 2016, n° 14-18.671 (F-P+B), Sté Blueshell Shipping Ltd c/ Sté Evrasia Bunker Ltd