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showing 10 items of 9912 documents

Usefulness of combining clinical and radiological dental findings for a more accurate noninvasive age estimation.

2007

: The aim of this study was to establish correlations of clinical and radiological dental findings, alone or in combination, with chronological age in adults. Dental findings and orthopantomograms of 984 patients (aged 20–60 years; 524 females/460 males) were analyzed. DMF-T index and distance (alveolar bone level, ABL) between cemento-enamel junction and alveolar bone margin were recorded. Additionally, clinical and radiological findings at each tooth crown and root were collected according to the actual status of destruction and restoration, and a total score for each dentition (TSD) was calculated. After univariate correlation analysis, correlation coefficients for ABL and TSD were impro…

AdultMaleAlveolar Bone LossDentistryDental CariesTooth crownPathology and Forensic MedicineCorrelationstomatognathic systemRadiography PanoramicGeneticsMedicineHumansTooth RootDental alveolusTooth CrownSex CharacteristicsDentitionbusiness.industryUnivariateMiddle AgedDentition Permanentstomatognathic diseasesAge estimationRadiological weaponCorrelation analysisRegression AnalysisFemaleAge Determination by TeethbusinessForensic DentistryJournal of forensic sciences
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Adult counting is resource demanding.

2004

Several recent studies on both the development of counting and working-memory span tasks have provided results that could be interpreted as ruling out any cognitive resource model for counting. The aim of this study was to test the hypothesis that, even in adults, counting is a demanding task that requires the allocation of cognitive resources. In a first experiment, we asked adults to count arrays of dots while maintaining 5 items in memory (either digits or letters). As we predicted, the concurrent memory load did not increase the rate of errors but induced longer counting times. In a second experiment, we asked adults to count using either the numeric chain or the alphabet while they mai…

AdultMaleAnalysis of VarianceRecallWorking memoryCognitionTest (assessment)Developmental psychologyTask (project management)CognitionCognitive resource theoryMemory spanReaction TimeResource allocation (computer)HumansFemaleArithmeticPsychologyGeneral PsychologyMathematicsBritish journal of psychology (London, England : 1953)
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Antibodies to soluble liver antigen/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis.

2002

Antibodies to soluble liver antigen/liver-pancreas are highly specific markers of type 1 autoimmune hepatitis that have been associated with relapse. Our aim was to determine if these antibodies are reflective of a genetic predisposition for recrudescent disease.One hundred forty-four white North American patients were evaluated by an enzyme immunoassay and by Western blot using recombinant soluble liver antigen/liver-pancreas; 122 were assessed for class II human leukocyte antigens (HLAs).Twenty-two patients (15%) had antibodies to soluble liver antigen/liver-pancreas. These patients were indistinguishable from seronegative patients by clinical, laboratory, and histological features at pre…

AdultMaleAnti-nuclear antibodyBlotting WesternEnzyme-Linked Immunosorbent AssayAutoimmune hepatitisHuman leukocyte antigenAutoantigensRisk AssessmentSensitivity and SpecificityStatistics NonparametricHLA-DR3 AntigenRisk FactorsmedicineHLA-DR4 AntigenHumansProbabilityAutoimmune diseaseHepatitisHepatologybiologybusiness.industryGastroenterologyPanel reactive antibodyPancreatic DiseasesMiddle Agedmedicine.diseaseHepatitis Autoimmunemedicine.anatomical_structureSolubilityAntibodies AntinuclearImmunologybiology.proteinDrug Therapy CombinationFemaleAntibodyPancreasbusinessThe American journal of gastroenterology
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In vitro antifungal activity of allyl isothiocyanate (AITC) against Aspergillus parasiticus and Penicillium expansum and evaluation of the AITC estim…

2015

Abstract Isothiocyanates (ITCs) are natural compounds derived from cruciferous vegetables produced by enzymatic conversion of metabolites called glucosinolates. They are potentially useful antimicrobial compounds for food applications have been shown to be promising agents against cancer in human cell culture, animal models, and in epidemiological studies. In this study, the antifungal activity of the allyl isothiocyanate (AITC) was evaluated on two mycotoxigenic fungi as Aspergillus parasiticus and Penicillium expnsum , aflatoxins (AFs) and patulin (PAT) producers, employing an assay on solid medium. Also an approximation of the risk evaluation associated to the intake of food treated with…

AdultMaleAntifungal AgentsAdolescentFood spoilageToxicologyRisk AssessmentMicrobiologyPatulinYoung Adultchemistry.chemical_compoundDisk Diffusion Antimicrobial TestsIsothiocyanatesVegetablesHumansFood scienceChildAgedAged 80 and overbiologyCruciferous vegetablesPenicilliumGeneral MedicineMiddle Agedbiology.organism_classificationAllyl isothiocyanateBioactive compoundAspergillus parasiticusAspergilluschemistrySpainBrassicaceaePenicilliumFood PreservativesFemalePenicillium expansumFood ScienceFood and Chemical Toxicology
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Absence of cardiovascular autonomic dysfunction and vagal pancreatic impairment in idiopathic achalasia of the oesophagus

2007

Abstract  Extra-oesophageal autonomic dysfunction in idiopathic achalasia is not well documented, due to contradictory results reported. We aimed to study the cardiovascular and pancreatic autonomic function in patients with idiopathic achalasia. Thirty patients with idiopathic achalasia (16M/14F; 34.5 ± 10.8 years) and 30 healthy volunteers (13M/17F; 34.8 ± 10.7 years) were prospectively studied. Age >60 years and conditions affecting results of autonomic evaluation were excluded. Both groups underwent the sham feeding test and plasmatic levels of pancreatic polypeptide (PP) were determined by radioimmunoassay (basal, at 5, 10, 20 and 30 min). Cardiovascular parasympathetic (deep breathing…

AdultMaleAutonomic functionmedicine.medical_specialtyAdolescentPhysiologyDiaphragmatic breathingAchalasiaAutonomic Nervous SystemPancreatic PolypeptideEatingEsophagusInternal medicinemedicineHumansPancreatic polypeptideEndocrine and Autonomic Systemsbusiness.industryGastroenterologyVagus NerveRadioimmunoassayMiddle Agedmedicine.diseaseSham feedingEsophageal AchalasiaBlood pressureTasteAnesthesiaCardiologyMasticationFemaleIdiopathic achalasiabusinessNeurogastroenterology & Motility
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Functional anatomy of motor recovery after early brain damage

2004

Functional magnetic resonance imaging and transcranial magnetic stimulation were used to examine a 34 year-old right-handed patient, who, at the age of 6 years, had experienced sudden right hemiplegia, seizures, and stupor during a bout of measles encephalitis, followed by incomplete distal right motor recovery. Morphological MRI showed massive unilateral enlargement of the left ventricle, associated with extreme thinning of the white and gray matter, with partial preservation of the pyramidal tract. Functional MRI and transcranial magnetic stimulation revealed reorganization of the motor cortices, and integrity of the corticospinal pathway, respectively. Our findings indicate that complete…

AdultMaleCORTEXmedicine.medical_treatmentCHILDHOODAdult; Brain Damage Chronic; Humans; Magnetic Resonance Imaging; Magnetoencephalography; Male; Paresis; Psychomotor Performance; Subacute Sclerosing PanencephalitisCHILDRENBrain damageArts and Humanities (miscellaneous)Magnetic Resonance Imaging; Magnetoencephalography; Paresis; Humans; Brain Damage Chronic; Adult; Psychomotor Performance; Subacute Sclerosing Panencephalitis; MalemedicineHumansBrain DamagePLASTICITYChronicPyramidal tractsmedicine.diagnostic_testSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaStuporMagnetoencephalographyAnatomymedicine.diseaseMagnetic Resonance ImagingTranscranial magnetic stimulationParesismedicine.anatomical_structureVentricleBrain Damage ChronicMotor recoverySettore MED/26 - NeurologiaNeurology (clinical)Subacute Sclerosing Panencephalitismedicine.symptomFunctional magnetic resonance imagingPsychologyNeuroscienceEncephalitisSTROKEPsychomotor PerformanceMRI
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Smoking and Helicobacter pylori infection: an individual participant pooled analysis (Stomach Cancer Pooling- StoP Project)

2019

Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case- control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% confidence intervals (CIs) were estimated through random-effects meta-analysis…

AdultMaleCancer ResearchEpidemiologyPoolingserologyconsortiumRisk AssessmentsmokingHelicobacter Infections03 medical and health sciencesSex Factors0302 clinical medicineRisk FactorsStomach NeoplasmsPrevalenceTobacco SmokingmedicineHumanspooled analysi030212 general & internal medicineStomach cancerAgedSmokersHelicobacter pyloribusiness.industryAge FactorsPublic Health Environmental and Occupational HealthCase-control studyCancerindividual participant dataPublication biasOdds ratioMiddle Agedmedicine.diseaseConfidence intervalOncologyGastric MucosaCase-Control Studies030220 oncology & carcinogenesisFemalebusinessRisk assessmentDemographyEuropean Journal of Cancer Prevention
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The use of esmolol in whole-body hyperthermia: Cardiovascular effects

1997

Whole-body hyperthermia (WBH) is a well-described investigational adjunct to systemic chemotherapy for the treatment of advanced malignancies. The hemodynamic consequences of this physiologic state may include tachycardia, which can produce acute myocardial ischemia in patients with coronary artery disease. Ischemic heart disease is currently considered a contraindication to WBH. We chose to investigate the consequences of using a new beta 1-adrenergic antagonist, esmolol, to attempt to control the tachycardia associated with WBH. After institutional approval and patient consent, nine consecutive patients with normal cardiac function presenting for WBH with carboplatin infusion were studied…

AdultMaleCancer ResearchMean arterial pressureCardiac outputHeart diseasePhysiologySinus tachycardiaAdrenergic beta-AntagonistsCardiac indexAntineoplastic AgentsCoronary DiseaseCarboplatinPropanolaminesHeart RateNeoplasmsTachycardiaPhysiology (medical)Heart rateHumansMedicineInfusions Intravenousbusiness.industryContraindicationsHemodynamicsHyperthermia InducedMiddle Agedmedicine.diseaseEsmololCombined Modality TherapyAnesthesiaHeart failureFemaleSafetymedicine.symptombusinessmedicine.drugInternational Journal of Hyperthermia
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Clinical evaluation of pancreatitis-associated protein as a serum marker of hepatocellular carcinoma: Comparison with α-fetoprotein

1998

This study evaluated the significance of serum pancreatitis-associated protein (PAP) assay, as a marker of hepatocellular carcinoma (HCC), in comparison and combined with α-fetoprotein (AFP) assay. Sixty-five patients with HCC, 59 with liver cirrhosis (LC) and 68 asymptomatic controls (C) were studied. PAP and AFP values significantly increased from C to LC and HCC group (p < 0.0001). The area under receiver-operating characteristic (ROC) curve for the two markers was not statistically different. At 100% specificity, ROC analysis gave a cut-off level for AFP of 166 IU/l with 40% sensitivity, and a cut-off level of 240 µg/l for PAP with 23% sensitivity. Diagnostic accuracy of combined AFP…

AdultMaleCancer ResearchPathologymedicine.medical_specialtyCirrhosisCarcinoma HepatocellularPancreatitis-Associated ProteinsAsymptomaticSensitivity and SpecificityAntigens NeoplasmBiomarkers TumorMedicineHumansLectins C-TypeneoplasmsTumor markerAgedbusiness.industryLiver NeoplasmsGeneral MedicineMiddle Agedmedicine.diseasedigestive system diseasesLogistic ModelsOncologyHepatocellular carcinomaPancreatitisFemalealpha-Fetoproteinsmedicine.symptombusinessClinical evaluationSerum markersAcute-Phase Proteins
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Prognostic Value of Immunohistochemical Expression of Beta-1 Integrin in Pancreatic Carcinoma

1999

<i>Background: </i>Prognostically relevant factors based on the histological assessment of the resected pancreas are known. However, the knowledge of additional factors associated with the prognosis is helpful in planning the therapy for an individual patient. β<sub>1</sub> Integrin expression is known to have a prognostic influence in some malignant tumors. No data are, however, available on the prognostic value of β<sub>1</sub> integrins in pancreatic carcinoma. <i>Method: </i>We investigated paraffin-embedded specimens of 19 patients undergoing surgical treatment for periampullary carcinoma and of 42 patients for ductal pancreatic carcinoma…

AdultMaleCancer ResearchPathologymedicine.medical_specialtyPancreatic diseaseIntegrinFlow cytometryPredictive Value of TestsBeta 1 integrinHumansMedicineAgedNeoplasm StagingAged 80 and overmedicine.diagnostic_testbiologybusiness.industryCell adhesion moleculeIntegrin beta1CarcinomaGeneral MedicineMiddle AgedPrognosismedicine.diseaseImmunohistochemistryGene Expression Regulation NeoplasticPancreatic Neoplasmsmedicine.anatomical_structureOncologyLymphatic Metastasisbiology.proteinAdenocarcinomaImmunohistochemistryFemalebusinessPancreasOncology
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