Search results for "pani"
showing 10 items of 1803 documents
Post-Induction Management in Patients With Left-Sided RAS and BRAF Wild-Type Metastatic Colorectal Cancer Treated With First-Line Anti-EGFR-Based Dou…
2021
BackgroundFew data regarding post-induction management following first-line anti-epidermal growth factor receptor (EGFR)-based doublet regimens in patients with left-sided RAS/BRAF wild-type metastatic colorectal cancer (mCRC) are available.MethodsThis multicenter, retrospective study aimed at evaluating clinicians’ attitude, and the safety and effectiveness of post-induction strategies in consecutive patients affected by left-sided RAS/BRAF wild-type mCRC treated with doublet chemotherapy plus anti-EGFR as first-line regimen, who did not experience disease progression within 6 months from induction initiation, at 21 Italian and 1 Spanish Institutions. The measured clinical outcomes were: p…
Gibberellic acid and flower bud development in loquat (Eriobotrya japonica Lindl.)
2011
The application of gibberellic acid (GA 3) to the whole loquat tree from mid-May to early June and from early August to the onset of flowering, significantly reduced the number of premature flowering shoots per current shoot and per m 3 of canopy, and so reduced the total number of panicles per m 3 of canopy. The number of vegetative shoots per m 3 of canopy was also significantly reduced by applying GA 3. The response depended on the concentration applied and produced optimal results at 50mgl -1. Differences in the number of flowers per panicle and leaves per shoot were not significantly modified by the treatment. Nevertheless, GA 3 applied directly to the developing apex near to flower di…
Evaluación de las tarifas de las pensiones de accidentes de trabajo y enfermedades profesionales (2011-2015)
2017
Este trabajo analiza si las tarifas que se aplican para la determinación del denominado capital coste de pensiones derivadas de los accidentes de trabajo y enfermedades profesionales son las adecuadas. A partir de los datos de la Muestra Continua de Vidas Laborales y de la evolución de la longevidad de la población general en España, se estiman tablas de mortalidad para las contingencias de viudedad e invalidez que, combinadas con los parámetros económicos y financieros apropiados, permiten construir las bases técnicas actuarialmente justas para cada uno de los años objeto de análisis. Los resultados obtenidos sugieren que las tarifas aplicadas en el periodo 2011- 2014 han sido muy superior…
Une guerre sans héros ? La guerre civile dans la bande dessinée espagnole (1977-2009)
2011
La bande dessinée espagnole de l’après-franquisme, à contre-courant de tous les autres secteurs de l’édition depuis 20 ans, n’a jamais témoigné d’un grand intérêt pour le sujet de la Guerre civile qui a déchiré l’Espagne entre 1936 et 1939. Autre sujet d’étonnement, les représentations qu’elle a pu en faire s’opposent radicalement au schéma classique et attendu de la bande dessinée d’aventure qui exalte la figure du héros de guerre. Les œuvres étudiées dans cet article (la tétralogie de Carlos Giménez et celle de Antonio Hernández Palacios), aussi différentes soient-elles, ne montrent qu’une chose : la tragédie de la guerre. Contrary to all other publishing sectors over the past two decades…
Hispania en la obra geográfica de Agripa
2015
Marco Vipsanio Agripa (64/63-12 a.C.) estuvo en Hispania en 19 a.C. para dirigir la campaña que culminó la conquista romana de la península durante el principado de Augusto. Han quedado diversas menciones a la obra geográfica que, bajo sus auspicios, recogió distancias y medidas de todo el mundo conocido en su época, valiéndose de la enorme cantidad de recursos humanos y materiales que la administración romana estaba en disposición de poner a su alcance.
Geografía literaria y límites provinciales: la península Ibérica entre Eratóstenes y Agripa
2013
Desarrollamos aquí una revisión de la concepción geográfica de la península Ibérica, centrando el estudio de manera prioritaria en los fundamentos numéricos transmitidos por las principales fuentes geográficas del mundo antiguo. En esta panorámica, se evidencia la esencial importancia de las obras cartográficas de Eratóstenes y Agripa. La primera tendrá un influjo decisivo para el surgimiento de la literatura de contenido geográfico desarrollada por Polibio, Artemidoro y Posidonio, y servirá de sustento a la cartografía de Ptolomeo, que reproduce en sus líneas esenciales los resultados de Eratóstenes, pero filtrados a través de la intermediación crítica de Hiparco. La obra cartográfica de A…
De Montaigne a Lope: distintos resultados de una misma decisión
2009
This essay presents the initial hypothesis of the diversity of cases shown by Lope de Vega’s theatre, that multiply perspectives and different endings from the same basic types of conflicts and designs, and tries to verify them with contemporary thought. This diversity is related with a certain type of discourse that has begun to spread out in the very beginning of the Renaissance and was gradually displacing the pre-eminence of universal principles (neo-platonic, or neoaristotelic and scholastic) for an invitation to casuistic analysis, an ethical modality applied that chose the concrete analysis of the concrete situation in front of the universally required dogmas. A type of discourse tha…
Quantitative characterization of tetraspanin 8 homointeractions in the plasma membrane
2021
The spatial distribution of proteins in cell membranes is crucial for signal transduction, cell communication and membrane trafficking. Members of the Tetraspanin family organize functional protein clusters within the plasma membrane into so-called Tetraspanin-enriched microdomains (TEMs). Direct interactions between Tetraspanins are believed to be important for this organization. However, studies thus far have utilized mainly co-immunoprecipitation methods that cannot distinguish between direct and indirect, through common partners, interactions. Here we study Tetraspanin 8 homointeractions in living cells via quantitative fluorescence microscopy. We demonstrate that Tetraspanin 8 exists i…
A Golgi study of the principal projection neurons of the medial cortex of the lizardPodarcis hispanica
1997
The medial cortex of lizards is a simple three-layered brain region displaying many characteristics that parallel the hippocampal fascia dentata of mammals. Its principal neurons form a morphologically diverse population, partly as a result of the prominent continuous growth of this nervous center. By using the classic Golgi impregnation method, we describe here the morphology of the principal neurons populating the medial cortex of Podarcis hispanica. These were projection neurons giving off descending axons. These axons displayed deep collateral branches provided with prominent axonal boutons, while the main axonal branch reached adjacent cortical areas and the bilateral septum. According…
Regulation of IgG antibody responses by epitope density and CD21-mediated costimulation
2002
Epitope density and organization have been shown to be important factors for B cell activation in many animal model systems. However, it has been difficult to separate the role of antigen organization from the role of local antigen concentrations because highly organized antigens are usually particulate whereas non-organized antigens are more soluble. Hence, highly organized and non-organized antigens may interact with different cell types and in different locations within lymphoid organs. In order to assess the role of antigen organization in regulating B cell responses, we immunized mice with highly repetitive virus-like particles, which exhibit different epitope densities covalently atta…