Search results for "papi"
showing 10 items of 636 documents
Estudio del cáncer cutáneo no melanoma en pacientes trasplantados renales : incidencia y factores de riesgo asociados
2013
El cáncer cutáneo no melanoma (CCNM) es la neoplasia maligna más frecuente en pacientes trasplantados. Los objetivos fundamentales de esta tesis han sido valorar los factores de riesgo asociados a la aparición de CCNM en pacientes trasplantados renales en nuestra área, haciendo hincapié en el papel del tratamiento inmunosupresor y la implicación del virus del papiloma humano (VPH) en la etiopatogenia tumoral. Recogimos los datos de 289 pacientes trasplantados renales durante el periodo 1996-2010. Para la determinación de los factores de riesgo implicados en el desarrollo de CCNM elaboramos un estudio analítico observacional ambiespectivo. El periodo de recogida de datos comprendió desde ene…
Acerca del contorno costero de la Iberia de Artemidoro
2016
Son analizados los datos de distancias de entre puntos de la costa de Iberia recogidos en el recientemente editado "Papiro de Artemidoro" y son comparados con los ya conocidos a través de la tradición geográfica posterior al propio Artemidoro; se pone de manifiesto la notable disparidad entre ambos conjuntos de datos.
Trans-Abdominal Ultrasound Guided ERC in a Pregnant Woman With Bile Duct Stones
2014
Background: The change in lithogenicity of bile, increased stasis of bile and decreased gall bladder emptying are the possible reasons for an increased risk of gall stones during pregnancy. However, biliary interventions during pregnancy are associated with risks to both the pregnancy and developing fetus. ERC under fluoroscopic control as gold standard is associated with higher risk of premature labor and teratogenity. Methods and patient: We performed transabdominal ultra-sound guided ERC in one patient in the second trimenon with gall stones. While the hilus area is observed by ultrasound, the papilla is carefully cannulated with a guidewire. A contrast agent is applied in the common bil…
Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis
2008
HMGA1 is a member of a small family of architectural transcription factors involved in the coordinate assembly of multiprotein complexes referred to as enhanceosomes. In addition to their role in cell proliferation, differentiation, and development, high-mobility group proteins of the A type (HMGA) family members behave as transforming protoncogenes either in vitro or in animal models. Recent reports indicated that HMGA1 might counteract p53 pathway and provided an interesting hint on the mechanisms determining HMGA's transforming potential. HMGA1 expression is deregulated in a very large array of human tumors, including cervical cancer, but very limited information is available on the mole…
Paplašinātā realitāte mobilajās aplikācijās - tās nozīme mārketingā un ietekme uz patērētāju.
2021
Bakalaura tēma ir “Papildinātā realitāte mobilajās aplikācijās, tās nozīme mārketingā un ietekme uz patērētāju”. Darba mērķis ir, pamatojoties uz teorijas atziņām par mobilo lietotņu un papildinātās realitātes izmantošanas iespējām mārketingā un patērētāju aptaujas rezultātiem, izpētīt papildinātās realitātes ietekmi uz patērētājiem Latvijā, noskaidrot nozīmi mārketingā un sniegt priekšlikumus tās iekļaušanai Latvijas uzņēmumu mārketinga darbībā. Pētāmā problēma ir papildinātās realitātes mobilo aplikāciju ietekmes uz patērētājiem un nozīmes mārketingā pētīšanas nepieciešamība Latvijas tirgū. Darbs sastāv no 3 nodaļām. Pirmajā nodaļā tiek aplūkoti mobilo aplikāciju teorētiskie aspekti, lai …
Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection.
2014
ABSTRACT Several viruses, including human papillomaviruses, depend on endosomal acidification for successful infection. Hence, the multisubunit enzyme vacuolar ATPase (V-ATPase), which is mainly responsible for endosome acidification in the cell, represents an attractive target for antiviral strategies. In the present study, we show that V-ATPase is required for human papillomavirus (HPV) infection and that uncoating/disassembly but not endocytosis is affected by V-ATPase inhibition. The infection inhibitory potencies of saliphenylhalamide, a proven V-ATPase inhibitor, and its derivatives, as well as those of other V-ATPase inhibitors, were analyzed on different HPV types in relevant cell l…
Comparison of the performance of different HPV genotyping methods for detecting genital HPV types
2008
Classification of high-risk HPV types for cervical cancer screening depends on epidemiological studies defining HPV type-specific risk. The genotyping tests that are used, are however, not uniform with regard to type-specific detection rates making comparisons between different studies difficult. To overcome the lack of a “gold standard” four tests were evaluated crosswise using 824 cervical smears pretested by HC2. The tests evaluated were the L1-PCR-based assays PGMY09/11 LBA, HPV DNA Chip and SPF LiPA and an E1 consensus PCR followed by cycle sequencing (E1-PCR). A subset of 265 samples was tested in addition with the GP5+/6+ reverse line blot assay. Differences were noted in the sensiti…
PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery.
2019
Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing within PML NBs. Often, large DNA viruses disassemble and reorganize PML NBs to counteract their intrinsic antiviral activity and support establishment of infection. However, human papillomavirus (HPV) requires PML protein to retain incoming viral DNA in the nucleus for subsequent efficient transcription. In contrast, Sp100 was identified as a restriction factor for HPV. These findings suggested that PML NBs are important regulators of early stages o…
Akadēmiskā Dzīve, 47.krājums
2011
Solid papillary carcinoma with reverse polarity of the breast displays morphologic, immunohistochemical and molecular characteristics in comparison t…
2018
IF 6.655 (2017); International audience