Search results for "park"

Cholesterol facilitates interactions between α‐synuclein oligomers and charge‐neutral membranes

2015

AbstractOligomeric species formed during α-synuclein fibrillation are suggested to be membrane-disrupting agents, and have been associated with cytotoxicity in Parkinson’s disease. The majority of studies, however, have revealed that the effect of α-synuclein oligomers is only noticeable on systems composed of anionic lipids, while the more physiologically relevant zwitterionic lipids remain intact. We present experimental evidence for significant morphological changes in zwitterionic membranes containing cholesterol, induced by α-synuclein oligomers. Depending on the lipid composition, model membranes are either unperturbed, disrupt, or undergo dramatic morphological changes and segregate …

STUDIO DELL’INDIVIDUAZIONE DEL PARKINSON TRAMITE ANALISI DELLE CARATTERISTICHE VOCALI ATTRAVERSO METODI DI OTTIMIZAZIONE STOCASTICA

Animal Perception of Seasonal Thresholds: Changes in Elephant Movement in Relation to Rainfall Patterns

2012

Background The identification of temporal thresholds or shifts in animal movement informs ecologists of changes in an animal’s behaviour, which contributes to an understanding of species’ responses in different environments. In African savannas, rainfall, temperature and primary productivity influence the movements of large herbivores and drive changes at different scales. Here, we developed a novel approach to define seasonal shifts in movement behaviour by examining the movements of a highly mobile herbivore (elephant; Loxodonta africana), in relation to local and regional rainfall patterns. Methodology/Principal Findings We used speed to determine movement changes of between 8 and 14 GPS…

40 Years of Breeding Bird Community Dynamics in a Primeval Temperate Forest (Białowieża National Park, Poland)

2015

We documented the composition and structure of the breeding bird assemblage in the primeval temperate forest of the Bialowieza National Park (BNP), during 2010-2014, and used 40 years of data to assess patterns of its diver- sity. We applied an improved version of the mapping technique (a combined mapping method) for forest birds in seven plots located in three old-growth forest types: ash-alder riverine, oak-hornbeam, and mixed coniferous. The composi- tion of the breeding avifauna and species richness remained basically unchanged. Jointly 67 (79% of 40-year total) breeding species were recorded in 2010-2014. Overall 49 (57%) of all species bred in the study plots in more than 35 years, th…

Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity.

2009

Strong evidence indicates that oxidative stress may be causally involved in the pathogenesis of Parkinson's disease. We have employed human dopaminergic neuroblastoma cells and rat primary mesencephalic neurons to assess the protective potential of three novel bisarylimine antioxidants on dopaminergic cell death induced by complex I inhibition or glutathione depletion. We have found that exceptionally low concentrations (EC(50) values approximately 20 nM) of these compounds (iminostilbene, phenothiazine, and phenoxazine) exhibited strong protective effects against the toxicities of MPP(+), rotenone, and l-buthionine sulfoximine. Investigating intracellular glutathione levels, it was found t…

Materiały do poznania fauny Kampinoskiego Parku Narodowego: Apionidae i Nanophyidae (Coleoptera: Curculionoidea)

2013

New localities of 35 species of Apionidae and 2 species of Nanophyidae in the Kampinos National Park are presented, among them respectively 26 and 2 species new for the studied area. Regarding Apionidae, 8 of 9 species recorded from the Kampinos National Park in literature, were confirmed to occur there. Perapion oblongum (GYLL.) has been recorded from the Mazovian Lowland for the first time

Neuronal cell cycle: the neuron itself and its circumstances.

2015

Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined developmental program that induces DNA replication in specific populations of neurons, which remain in a tetraploid state for the rest of their adult life. Similarly, de novo neuronal tetraploidization has also been described in the adult brain as an early hallmark of neurodegeneration. The aim of this review is to integrate these recent developments in the context of cell cycle regulation and apoptotic cell death in neurons. We conclude that a variety of mechanisms exists in neuronal cells for G1/S and G2/M check…

The Archaelogical Park of the ‘Valle dei Templi’ in Agrigento: Cultural Landscape between Conservation, Development and Sustainability

2008

GIS and Survey in the Archaeological and Landscape Park of Agrigento

2017

Si espongono in maniera sintetica la metodologia e i risultati della prospezione archeologica condotta nell'area del Parco archeologico e paesaggistico di Agrigento. I dati raccolti con il survey e con l'esame delle riprese aeree storiche e attuali e di riprese satellitari sono confluiti in un Sistema Informativo Territoriale, che permetterà la gestione attiva delle aree archeologiche comprese nel Parco. Il sistema inoltre permetterà di comprendere meglio il rapporto insediativo, culturale e simbolico tra la colonia greca e il territorio suburbano. The methodology and the results of the archaeological survey carried out in the area of ​​the Archaeological and Landscape Park of Agrigento are…

Integrated use of unmanned aerial vehicle photogrammetry and terrestrial laser scanning to support archaeological analysis: The Acropolis of Selinunt…

2021

Southwestern Sicily is an area of infrequent seismic activity; however, some studies carried out in the archaeological Selinunte site suggest that, between the fourth century BC and the early Middle Ages, probably at least two earthquakes strucked this area with enough energy to damage and cause the collapse and kinematics of much of the architecture of Selinunte. Take into account that, in 2008, a noninvasive archaeological prospection and traditional data gathering methods along the Acropolis north fortifications were carried out. Following these first studies, after about 10 years, a new geophysical campaign was carried out. This second campaign benefited from the application of modern t…