Search results for "pathogen"
showing 10 items of 1657 documents
Zur Genese der posttraumatischen Sp�tapoplexie
1956
Aus dem klinischen Verlauf, dem makroskopischen und histologischen Befund eines Falles traumatischer Spatapoplexie wird versucht, die Zur Genese der posttraumatischen Spatapoplexie Genese dieses seltenen Krankheitsbildes zu klaren. Es wird vermutet, das das Trauma auf Grund einer anormalen vegetativen Ausgangslage des Hirngefassystems zu Durchblutungsstorungen fuhrt, die nicht kompensiert werden konnen, sondern zu Ausfallen in der Hirnsubstanz fuhren, die ihrerseits wieder reflektorische Durchblutungsstorungen auslosen. Ursache der apoplektischen Blutungen sind regressive, im Sinne der DysorieSchUrmanns, geschadigte Gefase bei plotzlicher Blutdrucksteigerung.
Experimental Hepatitis
1994
Publisher Summary This chapter presents the animal models of experimental hepatitis (EAH). EAH was developed as a model of human autoimmune hepatitis (AIH). AIH in humans is a heterogeneous disease, which most often occurs in young females and generally responds very well to immunosuppressive therapy. AIH is often not recognized or is misdiagnosed as chronic non-A, non-B (non-C) viral hepatitis. Even when left untreated for considerable time periods, the disease in some patients is moderate to mild, and transient spontaneous remissions can be observed. EAH in many ways reflects this disease process. EAH also is often mild to moderate, and spontaneous remission occurs. Autoantibodies are cri…
Pathogenesis of Sepsis Syndrome: Possible Relevance of Pore-Forming Bacterial Toxins
1996
This review focuses on a group of bacterial products whose very existence is known to only a minority of clinicians, and whose potential significance as inducers of the sepsis syndrome has eluded the attention of most microbiologists. This is unfortunate because pore-forming bacterial toxins possess all the properties for contributing to the pathogenesis of local and systemic inflammatory reactions. Because pore formers generally are highly immunogenic proteins, the prospects for immune intervention are described that may eventually be of benefit to patients. The subject is therefore of interest not only from a theoretical but also from a practical point of view.
Current Trends in Prostate Cancer Etiology, Pathogenesis and Diagnostics
2021
Abstract Prostate cancer (PCa) remains the second most commonly diagnosed cancer in men, with an estimated 1.1 million diagnoses worldwide in 2012, accounting for 15% of all cancers diagnosed. In many cases, successful treatment of prostate cancer is difficult due to late detection and rate of metastasis. Importantly, the tumours of many patients with prostate cancer become refractory to androgen therapy and progress to metastatic castration-resistant disease. An effective treatment course of prostate cancer patients requires predictive biomarkers in metastatic castration-resistant prostate cancer that support individual treatment. Different risk classification tools have been developed to …
Evidence against the role for dural arteriovenous fistulas in the pathogenesis of multiple sclerosis
2008
Die Bedeutung der Niere bei der Entstehung der nephrotischen Hyperlipämie
2009
Implications of alpha- and beta-secretase expression and function in Alzheimer's disease
2020
Abstract There has been intense debate in the field about the extent to which processing of the amyloid precursor protein contributes to pathogenesis of Alzheimer's disease. Early publications succeeding in the identification of the main component of senile plaques—the amyloid-beta (A-beta) peptide—strictly argued for a constitutive contribution of A-beta to disease initiation and progression. This led to development of the amyloid hypothesis, which in recent years was attacked for the lack of success of clinical studies based on the respective assumption. There is evidence that the hypothesis must be revisited, but accumulation of A-beta along with aging might still be the best explanation…