Search results for "pcos"

showing 10 items of 63 documents

Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes

2009

Abstract OBJECTIVE: To evaluate the clinical and endocrine differences between main polycystic ovary syndrome (PCOS) phenotypes. DESIGN: To evaluate clinical and hormone parameters in a large group of consecutive women with PCOS diagnosed according Rotterdam criteria and divided according their phenotype. SETTING: University department of medicine. PATIENT(S): Three hundred eighty-two consecutive women with PCOS and 85 ovulatory controls. INTERVENTION(S): Evaluation of clinical and hormone parameters. MAIN OUTCOME MEASURE(S): Blood levels of gonadotropins, testosterone, sex-hormone-binding globulin, dehydroepiandrosterone sulfate, 17α-hydroxyprogesterone, progesterone, glucose, and insulin,…

AdultPCOS Lipids Insulin resistance Fertility Androgens Obesitymedicine.medical_specialtySettore MED/09 - Medicina Internaendocrine system diseasesEndocrine SystemSettore MED/13 - EndocrinologiaAnovulationYoung Adultchemistry.chemical_compoundDehydroepiandrosterone sulfateSex Hormone-Binding GlobulinInternal medicinePrevalencemedicineHumansTestosteroneRetrospective StudiesDehydroepiandrosterone SulfateFree androgen indexbusiness.industryHyperandrogenismObstetrics and GynecologyLuteinizing Hormonemedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaPolycystic ovaryfemale genital diseases and pregnancy complicationsPhenotypeEndocrinologyReproductive MedicinechemistryCase-Control StudiesAndrogensFemaleFollicle Stimulating HormoneHyperandrogenismLuteinizing hormonebusinessPolycystic Ovary SyndromeHormoneFertility and Sterility
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PCOS: metabolic impact and long-term management.

2012

Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in women, affecting up to 10% of those in reproductive age. Furthermore, PCOS presents a lifetime risk of type II diabetes, cardiovascular diseases and endometrial cancer. Women with PCOS have increased cardiovascular risk; however, the risk is not the same in all patients and it is necessary to assess an individual risk profile. There is a discrepancy between increased cardiovascular risk at young age and postmenopausal number of cardiovascular events, probablu depending on changes in androgen ovarian function after the forties. However, changes with age of metabolic profile in women with PCOS have not been studied yet an…

AdultSettore MED/09 - Medicina InternaAdolescentComorbiditySettore MED/11 - Malattie Dell'Apparato CardiovascolareMetforminSettore MED/13 - EndocrinologiaDiabetes Mellitus Type 2Cardiovascular DiseasesRisk FactorsObesity AbdominalPCOS Metabolic Syndrome Cardiovascular risk aging insulin resistance hyperandrogenismHypertensionHumansFemaleHydroxymethylglutaryl-CoA Reductase InhibitorsInsulin ResistanceChildAntihypertensive AgentsDyslipidemiasPolycystic Ovary SyndromeMinerva ginecologica
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Low estradiol-to-testosterone ratio is associated with oligo-anovulatory cycles and atherogenic lipidic pattern in women with polycystic ovary syndro…

2010

The estradiol-to-testosterone (E2/T) ratio has been investigated in different diseases but few in vivo data are available with regard to its role in women with ovary syndrome (PCOS). The aim of this study was to evaluate the role of the E2/T ratio in the ovulatory function and metabolic pattern in such women.We retrospectively evaluated hyperandrogenemia, clinical hyperandrogenism, ovarian morphology, hypothalamo-hypophyseal axis and metabolic syndrome parameters in a cohort of 202 consecutive women affected by PCOS. An oral glucose tolerance test measured areas under the curve for insulin (AUC(2hIRI)), for glucose (AUC(2hglucose)), and the HOMA-IR and Matsuda index of insulin resistance we…

Adultmedicine.medical_specialtyAdolescentEndocrinology Diabetes and Metabolismmedia_common.quotation_subjectOvarySettore MED/13 - EndocrinologiaCohort StudiesYoung AdultEndocrinologyInsulin resistanceRisk FactorsInternal medicineFollicular phasePCOSmedicineHumansTestosteroneSicilyOvulationProgesteroneMenstrual cycleRetrospective Studiesmedia_commonEstradiolbusiness.industryOvaryHyperandrogenismObstetrics and GynecologyAtherosclerosismedicine.diseasePolycystic ovaryCholesterolEndocrinologymedicine.anatomical_structureFollicular PhaseFemaleMetabolic syndromeHyperandrogenismbusinessAlgorithmsAnovulationPolycystic Ovary SyndromeGynecological Endocrinology
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The oligomenorrhoic phenotypes of polycystic ovary syndrome are characterized by a high visceral adiposity index: a likely condition of cardiometabol…

2011

BACKGROUND: Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dys- lipidemia and hypertension, which are characteristic features of a condition of cardiometabolic risk. Our objective was to investigate the relationship between visceral adiposity index (VAI) and phenotypic characteristics in women with PCOS. METHODS: We conducted a cross-sectional case-control study in our Endocrinology Outpatients Clinic. A total of 220 women with PCOS (Rotterdam definition) and I44 age- and BMI-matched healthy women were studied. We evaluated hyperandrogenemia and clinical hyperandrogenism, ovarian morphology, hypothalamic-hypophyseal axis and …

Adultmedicine.medical_specialtyAdolescentPopulationIntra-Abdominal FatSettore MED/13 - EndocrinologiaInsulin resistanceRisk FactorsInternal medicinemedicinePCOSHumanseducationAdiposityRetrospective StudiesMetabolic Syndromeeducation.field_of_studyGlucose tolerance testmedicine.diagnostic_testbusiness.industryRehabilitationHyperandrogenismCase-control studyObstetrics and GynecologyOdds ratioGlucose Tolerance Testmedicine.diseasePolycystic ovaryOligomenorrheaPhenotypeEndocrinologyReproductive MedicineCardiovascular DiseasesCase-Control StudiesFemaleInsulin ResistanceMetabolic syndromebusinessPolycystic Ovary Syndrome
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Cardiovascular events among reproductive and menopausal age women with polycystic ovary syndrome: a systematic review and meta-analysis

2019

This study aimed to evaluate the prevalence (P)/hazard ratio (HR) of cardiovascular (CV) events among reproductive age and menopausal age women with polycystic ovary syndrome (PCOS) in comparison with healthy controls. PubMed, Scopus, ScienceDirect, Web of science, and Google scholar were searched for retrieving observational studies published up to April 2018 investigating CV events in patients with PCOS. The primary outcomes were a composite outcome of CV events [including coronary arterial disease (CAD), cardiovascular disease (CVD), myocardial infarction (MI), angina, heart failure, and ischemic heart disease] and mortality due to CV events; secondary outcomes were specific CVD events, …

Adultmedicine.medical_specialtyEndocrinology Diabetes and MetabolismPopulationMyocardial InfarctionMyocardial Ischemia030209 endocrinology & metabolismCoronary Artery DiseaseAngina PectorisAngina03 medical and health sciences0302 clinical medicineEndocrinologyInternal medicinePrevalencemedicineHumansMyocardial infarctionRisk factoreducationAgedProportional Hazards ModelsHeart Failureeducation.field_of_study030219 obstetrics & reproductive medicinebusiness.industryPolycystic ovary syndrome (PCOS)Hazard ratioObstetrics and GynecologyMiddle Agedmedicine.diseasePolycystic ovaryStrokeCerebrovascular DisordersCardiovascular DiseasesCase-Control StudiesFemalebusinessPolycystic Ovary SyndromeCohort studyGynecological Endocrinology
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Prospective Parallel Randomized, Double-Blind, Double-Dummy Controlled Clinical Trial Comparing Clomiphene Citrate and Metformin as the First-Line Tr…

2005

Abstract Context: Although metformin has been shown to be effective in the treatment of anovulation in women with polycystic ovary syndrome (PCOS), clomiphene citrate (CC) is still considered to be the first-line drug to induce ovulation in these patients. Objective: The goal of this study was to compare the effectiveness of metformin and CC administration as a first-line treatment in anovulatory women with PCOS. Design: We describe a prospective parallel randomized, double-blind, double-dummy controlled clinical trial. Setting: The study was conducted at the University “Magna Graecia” of Catanzaro, Catanzaro, Italy. Patients: One hundred nonobese primary infertile anovulatory women with PC…

Adultmedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentClinical BiochemistryWEIGHT-LOSSIMPROVEMENTContext (language use)PLACEBO-CONTROLLED TRIALPlaceboTHERAPYBiochemistrylaw.inventionAnovulationEndocrinologyDouble-Blind MethodOvulation InductionRandomized controlled trialClomifenelawinsulin resistanceInternal medicinePCOSmedicineHumansCRITERIAclomipheneProspective StudiesPolycystic ovary syndromeGynecologybusiness.industryBiochemistry (medical)medicine.diseasePolycystic ovarymetformineMetforminPREGNANCYEndocrinologyPCOS; metformine; clomipheneovulationFemaleOvulation inductionGLUCOSE-TOLERANCEclomifenemetforminbusinessOBESE WOMENAnovulationmedicine.drugThe Journal of Clinical Endocrinology & Metabolism
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Lower insulin sensitivity differentiates hirsute from non-hirsute Sicilian women with polycystic ovary syndrome

2006

Objective: It is well known that hyperandrogenism and insulin-resistance with or without compensatory hyperinsulinism are closely associated, but the Rotterdam Consensus has concluded that principally obese women with polycystic ovary syndrome (PCOS) should be evaluated for the metabolic syndrome. Our aim was to study insulin sensitivity in PCOS women with hirsutism regardless of obesity. Methods: Clinical characteristics, sex hormones and fasting- and after OGTT-glycemia and insulinemia, homeostatic model of insulin resistance (HOMA IR), and Matsuda index of insulin sensitivity were analyzed in 130 women with PCOS. Hirsutism has been evaluated through the Ferriman–Gallwey (FG) map scoring …

Adultmedicine.medical_specialtyHirsutismAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentSettore MED/13 - EndocrinologiaDiagnosis DifferentialEndocrinologyInsulin resistanceInternal medicineHyperinsulinismmedicineHumansTestosteroneObesitySicilyhirsutismMetabolic Syndromebusiness.industryDehydroepiandrosterone SulfateInsulinHyperandrogenismAndrostenedioneGeneral Medicinemedicine.diseasePolycystic ovaryEndocrinologyPCOS INSULIN RESISTANCE HIRSUTISMFemaleMetabolic syndromeInsulin ResistancebusinessHyperandrogenismHyperinsulinismBody mass indexPolycystic Ovary Syndrome
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Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome.

2008

Abstract BACKGROUND: Dyslipidemia is a common metabolic complication in polycystic ovary syndrome (PCOS). The aim of this study was to determine if differences exist in dyslipidemia in women with PCOS from different ethnic and geographical backgrounds. METHODS: This retrospective study evaluated the serum fasting lipid profiles of 106 women with PCOS from the United States and 108 women with PCOS from Italy evaluated at endocrinology clinics. RESULTS: American women had higher mean body mass index than Italian women (36.1+/-8.6 vs 28.1+/-5.8 kg/m2, p<0.01). Low HDL-cholesterol was the most prevalent lipid abnormality in both populations. U.S. women had higher mean levels of serum total chol…

Adultmedicine.medical_specialtySettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismEthnic groupPhysiologySettore MED/13 - EndocrinologiaBody Mass IndexCohort StudiesEndocrinologyRisk FactorsmedicinePrevalenceHumansObesityPCOS Hyperandrogenism Cardiovascular risk dyslipidemia LDL-cholesterolDyslipidemiasRetrospective StudiesGynecologybusiness.industryRetrospective cohort studyOverweightmedicine.diseaseObesityPolycystic ovarySettore MED/40 - Ginecologia E OstetriciaLipidsConfidence intervalUnited StatesItalyCardiovascular DiseasesFemalebusinessBody mass indexDyslipidemiaCohort studyPolycystic Ovary SyndromeJournal of endocrinological investigation
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Metformin modulates human leukocyte/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients

2015

Abstract Objective We aim to assess the effect of metformin treatment on metabolic parameters, endothelial function and inflammatory markers in polycystic ovary syndrome (PCOS) subjects. Methods The study population consisted of 40 reproductive-age women with PCOS, who underwent treatment with metformin during a 12-week period, and their corresponding matched controls (n = 44). We evaluated endocrinological parameters, adhesion molecules (vascular cell adhesion molecule 1 (VCAM-1), intercellular cell adhesion molecule 1 (ICAM-1) and E-selectin) and proinflammatory cytokines (interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα)) in serum. In addition, interactions between human umbili…

Adultmedicine.medical_specialtyTime FactorsAdolescentendocrine system diseasesEndotheliumType 2 diabetesProinflammatory cytokineYoung AdultInsulin resistanceInternal medicineCell AdhesionHuman Umbilical Vein Endothelial CellsLeukocytesmedicineHumansLeukocyte RollingEndothelium Leukocyte Metformin Mitochondria PCOS Type 2 diabetesCells CulturedCell adhesion moleculebusiness.industryEndothelial Cellsnutritional and metabolic diseasesmedicine.diseasePolycystic ovaryCoculture TechniquesMetforminMetforminEndothelial stem cellTreatment Outcomemedicine.anatomical_structureEndocrinologyDiabetes Mellitus Type 2SpainCytokinesFemaleInflammation MediatorsCardiology and Cardiovascular MedicinebusinessCell Adhesion MoleculesBiomarkersPolycystic Ovary Syndromemedicine.drugAtherosclerosis
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Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): a comparative analysis of …

2013

Study question Is it possible to distinguish metabolically healthy polycystic ovary syndrome (MH-PCOS) from metabolically unhealthy PCOS (MU-PCOS) by simple diagnostic tools such as body mass index (BMI), waist/hip ratio (WHR), at-risk category suggested by Androgen Excess Society (AES) and visceral adiposity index (VAI)? Summary answer VAI could be an easy and useful tool in clinical practice and in population studies for assessment of MU-PCOS. What is known already VAI is a good indicator of insulin sensitivity and cardiometabolic risk in oligo-ovulatory women with PCOS. Study design, size, duration We conducted a cross-sectional study of 232 women with PCOS in a university hospital setti…

Adultmedicine.medical_specialtyWaistAdolescentPopulationSettore MED/13 - EndocrinologiaDiagnosis DifferentialInsulin resistanceRisk FactorsInternal medicinemedicinePCOSHumanseducationAdiposityeducation.field_of_studybusiness.industryRehabilitationnutritional and metabolic diseasesObstetrics and GynecologyOdds ratioGlucose Tolerance Testmedicine.diseasePolycystic ovaryConfidence intervalCross-Sectional StudiesPhenotypeReproductive MedicineFemaleMetabolic syndromeInsulin ResistancebusinessEnergy MetabolismBody mass indexPolycystic Ovary SyndromeHuman reproduction (Oxford, England)
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