Search results for "penetration"
showing 10 items of 168 documents
Considerations on Dop (Depth Of Penetration) Test for Evaluation of Ceramics Materials Used in Ballistic Protection
2017
AbstractTremendous amount of funds and other resorces were invested in studying the response of ceramic materials under ballistic impact, the main goal being to find a way to increase the protection of soldiers and the vehicles used in the modern battlespace. Using of ceramic materials especially carbon based (carbides), nitrogen based (nitrides) and oxygen based (oxides) ceramics in order to increase the protection level of ballistic equipment could be, sometimes, a big challenge when trying to use the proper test in order to evaluate and compare their performances. The role of the tests is to provide a better understanding of their response in different situations and, as a consequence, t…
TOPS-MODE approach for the prediction of blood-brain barrier permeation.
2004
The blood-brain barrier permeation has been investigated by using a topological substructural molecular design approach (TOPS-MODE). A linear regression model was developed to predict the in vivo blood-brain partitioning coefficient on a data set of 119 compounds, treated as the logarithm of the blood-brain concentration ratio. The final model explained the 70% of the variance and it was validated through the use of an external validation set (33 compounds of the 119, MAE = 0.33), a leave-one-out crossvalidation (q(2) = 0.65, S(press) = 0.43), fivefold full crossvalidation (removing 28 compounds in each cycle, MAE = 33, RMSE = 0.43) and the prediction of +/- values for an external test set …
Phase coexistence in a triolein-phosphatidylcholine system. Implications for lysosomal membrane properties.
2010
The effects of tri- and monoglycerides on phospholipid (POPC) membranes were studied using spectroscopical methods. Triolein was found to form two types of POPC-rich membranes, both with POPC or as a three-component system with monopalmitin. These two membrane types were determined as co-existing phases based on their spontaneous and stable separation and named heavy and light phase according to their sedimentation behaviour. Marked differences were seen in the physical properties of these phases, even though only minor compositional variation was detected. The light, less polar phase was found to be less ordered and more fluid and seemed to allow significantly lower amount of water penetra…
Penetration of Streptococcus sobrinus and Streptococcus sanguinis into dental enamel.
2015
Abstract The aim of this pilot study was to assess the difference in virulence of acidogenic and aciduric oral streptococci in an in vitro caries model using their penetration depths into dental enamel. 30 caries-free extracted molars from 11- to 16-year-olds were cleaned ultrasonically for 1 min with de-ionized water and, after air-drying, embedded in epoxy resin. After 8-h of setting at room temperature, the specimens were ground on the buccal side with SiC-paper 1200 (particle size 13–16 μm). Enamel was removed in circular areas sized 3 mm in diameter; the mean depth of removed enamel was 230 ± 60 μm. 15 specimens each were incubated anaerobically under standardized conditions with 24 h-…
Diffusion of naltrexone across reconstituted human oral epithelium and histomorphological features
2006
Abstract In transbuccal absorption a major limitation could be the low permeability of the mucosa which implies low drug bioavailability. The ability of naltrexone hydrochloride (NLX) to penetrate a resembling histologically human buccal mucosa was assessed and the occurrence of any histomorphological changes observed. We used reconstituted human oral (RHO) non-keratinised epithelium as mucosal section and a Transwell diffusion cells system as bicompartmental model. Buccal permeation was expressed in terms of drug flux ( J s ) and permeability coefficients ( K p ). Data were collected using both artificial and natural human saliva. The main finding was that RHO does not restrain NLX permeat…
Simulated effects of W dust ablation and deposition on the pedestal edge in JET D and DT experiments
2022
Abstract A modelling analysis is performed on JET D and DT discharges, where W dust influx across the separatrix, in the pedestal edge region may affect L–H–L mode transition. The experimental basis of the proposed approach stems from the observation that transient impurity events (TIEs) are often associated with the presence of a shower of particles seen in the camera images and with strong optical emission. If the localised source of radiation is a number of heated or ablated large dust particles, then the questions addressed here are: how far will the ablated dust material penetrate and what effect will this have on the edge of the pedestal in relevant JET D and in a high fusion yield D–…
Plasma levels and cerebrospinal fluid penetration by duloxetine in a patient with a non-fatal overdose during a suicide attempt
2009
Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake with weak activity on dopamine reuptake (Wong et al. 1993). Daily doses of 60 mg are effective in the acute treatment of major depression. Duloxetine is extensively metabolized by cytochrome P450 isoenzymes (CYP) 1A2 and to a lesser extent 2D6 (Lobo et al. 2008) to numerous non-active metabolites. Maximum plasma concentration occurs after 6 h, steady-state within 3 d and the mean terminal half-life is 12 h. Fatal outcomes have been reported for acute overdoses as low as 1000 mg, and symptoms of duloxetine overdose are well described. However, information about plasma levels of duloxetine and correspondin…
Quantitative subsurface defect detection in composite materials using a non-contact ultrasonic system
2002
The results of an experimental study conducted to detect subsurface defects in a thick Gr/PPS composite test sample using a noncontact ultrasonic system are presented. Surface waves are generated by a pulsed laser and detected by an air-coupled capacitance transducer. By controlling the surface wave wavelength through a shadow mask, it is possible to control surface wave penetration depth in the sample. Surface wave peak-to-peak amplitude is related to the near-surface material condition. Results indicate that signal amplitude decreases as the width of the defect increases and an approximately linear relation can be deduced.
Exponential and power-law mass distributions in brittle fragmentation
2004
Generic arguments, a minimal numerical model, and fragmentation experiments with gypsum disk are used to investigate the fragment-size distribution that results from dynamic brittle fragmentation. Fragmentation is initiated by random nucleation of cracks due to material inhomogeneities, and its dynamics are pictured as a process of propagating cracks that are unstable against side-branch formation. The initial cracks and side branches both merge mutually to form fragments. The side branches have a finite penetration depth as a result of inherent damping. Generic arguments imply that close to the minimum strain (or impact energy) required for fragmentation, the number of fragments of size $s…
Influence of inelastic couplings on 32S + 24MG sub-barrier fusion
1988
Elastic, inelastic and mutual excitation angular distributions have been measured for 32S+ 24Mg at 65, 75, 56.3, 95 and 110 MeV of 32S incident energy. The data have been analysed by optical model and coupled channel calculations. Energy-dependent optical potentials have been obtained which have been used to describe the 32S + 24Mg fusion data of Berkowitz et al2). Barrier penetration and coupled channel models are compared. It is found that the energy-dependence of the empirical potentials is essential if a consistent simultaneous description of elastic, inelastic an fusion data is required.