Search results for "perch"

Inhibition of xanthine oxidase to prevent statin-induced myalgia and rhabdomiolysis

2015

Although statins remain the cornerstone of lipid-lowering therapy for reducing the burden of atherosclerotic vascular disease, their administration has been associated with muscle-related adverse effects, including myalgia and rhabdomyolysis. Such adverse events are probably due to reduced antioxidant defenses associated with fewer intermediate metabolites in the cholesterol synthesis pathway. We hypothesize that the concomitant inhibition of xanthine oxidase via coadministration of allopurinol with statins could diminish reactive oxygen species (ROS)-related muscle damage, which would have in turn have positive effects on both the incidence of muscle-related adverse events and cardiovascul…

Open-label ODYSSEY APPRISE study: Interim data from the first 843 participants

2018

Background PCSK9 inhibitors (PCSK9i) have been recommended by the ESC/EAS Task Force in very high risk subjects with ASCVD and those with heterozygous familial hypercholesterolemia (HeFH) with persistent high LDL-C levels despite maximally tolerated LLT. Purpose ODYSSEY APPRISE (NCT02476006) is the first study to assess efficacy and safety at Week (W) 12 of the PCSK9i alirocumab (ALI) in a real-life setting prior to commercial availability. Methods APPRISE was an open-label, single-arm study, conducted in 16 European countries and Canada. Subjects with inadequately controlled lipid levels despite maximally tolerated LLT were included. Based on physician's judgment, participants received eit…

Influencia de la instrumentación con lima única en la calidad de la obturación del sistema de conductos radiculares mediante la técnica de condensaci…

2015

1.- Introducción: el principal objetivo en la terapia endodóncica es simplificar los procedimientos con completa seguridad y eficacia. Como alternativa a los sistemas rotatorios multilima, se crearon los sistemas de lima única de rotación alternante, con el fin de reducir la fatiga cíclica para disminuir el riesgo de fractura de los instrumentos, la deformidad del conducto radicular, rapidez y simplicidad en la conformación. Posteriormente, aparecieron sistemas de lima única de rotación continua que también aumentaron la rapidez y la simplicidad. Con la finalidad de analizar la capacidad de conformar los conductos radiculares de estos sistemas endodóncicos se realizó este estudio. 2.- Objet…

FACTORS AFFECTING THE SPECTROPHOTOMETRIC QUANTIFICATION OF FLAVONOIDS IN WINE

2019

The quantification of flavonoids in wine and grape skin extract by spectrophotometric evaluation at 280 nm wavelength provides essential information to oenologist concerning wine composition and evolution, and it is commonly applied in wine labs. The measurement of the absorption peak height at 280 nm reported by DI STEFANO and GUIDONI (1989) allows to selectively quantify flavonoids with minor interferences. However, it has proved to be susceptible to SO2 at low pH or acetone in unpurified grape skin extracts. Moreover, the effect of pH on flavonoids quantification in wine, either containing SO2 or not, has not been assessed. The effect of SO2, purification, pH and dilution solvent on spec…

Efficacy of Long-Term Treatment of Autosomal Recessive Hypercholesterolemia With Lomitapide: A Subanalysis of the Pan-European Lomitapide Study

2022

Backgroundand aim: Autosomal recessive hypercholesterolemia (ARH) is a rare autosomal recessive disorder of low-density lipoprotein (LDL) metabolism caused by pathogenic variants in the LDLRAP1 gene. Like homozygous familial hypercholesterolemia, ARH is resistant to conventional LDL-lowering medications and causes a high risk of atherosclerotic cardiovascular diseases (ASCVDs) and aortic valve stenosis. Lomitapide is emerging as an efficacious therapy in classical HoFH, but few data are available for ARH.Results: This is a subanalysis carried out on nine ARH patients included in the Pan-European Lomitapide Study. The age at starting lomitapide was 46 (interquartile range (IQR), 39.0–65.5) y…

CCDC 991416: Experimental Crystal Structure Determination

2015

Related Article: Mithun Das, Bikash Kumar Shaw, Biswa Nath Ghosh, Kari Rissanen, Shyamal Kumar Saha, Shouvik Chattopadhyay|2015|RSC Advances|5|46869|doi:10.1039/C5RA07548C

CCDC 238750: Experimental Crystal Structure Determination

2005

Related Article: M.Ruben, U.Ziener, J.-M.Lehn, V.Ksenofontov, P.Gutlich, G.B.M.Vaughan|2005|Chem.-Eur.J.|11|94|doi:10.1002/chem.200400584

CCDC 781469: Experimental Crystal Structure Determination

2011

Related Article: J.Mercurol, Yanling Li, E.Pardo, O.Risset, M.Seuleiman, H.Rousseliere, R.Lescouezec, M.Julve|2010|Chem.Commun.|46|8995|doi:10.1039/c0cc02024a

Wytyczne PTL/KLRWP/PTK/PTDL/PTD/PTNT diagnostyki i leczenia zaburzeń lipidowych w Polsce 2021

2021

CCDC 136825: Experimental Crystal Structure Determination

2001

Related Article: T.Schneppensieper, G.Liehr, R.van Eldik, J.Ensling, P.Gutlich|2000|Inorg.Chem.|39|5565|doi:10.1021/ic000108f