Search results for "perinatology"

Effective childhood cancer treatment: The impact of large scale clinical trials in Germany and Austria

2013

In Germany and Austria, more than 90% of pediatric cancer patients are enrolled into nationwide disease-specific first-line clinical trials or interim registries. Essential components are a pediatric cancer registry and centralized reference laboratories, imaging review, and tumor board assistance. The five-year overall survival rate in countries where such infrastructures are established has improved from 80% since 1995. Today, treatment intensity is tailored to the individual patient's risk to provide the highest chances of survival while minimizing deleterious late effects. Multicenter clinical trials are internationalized and serve as platforms for further improvements by novel drugs an…

P03-010-B - A novel mutation in MEFV gene is not enough

2013

Genotype-phenotype correlation is still challenging in FMF patients especially when the disease is part of a complex autoinflammatory disease.

Musculoskeletal manifestations and orthopaedic problems in patients with mucopolysaccharidosis - an overview

2007

The value of Ems Mineral Salts in the treatment of rhinosinusitis in children

2005

Summary The treatment of rhinosinusitis seen in the light of uncertain pathogenesis and variable symptoms is under discussion and ranges from the administration of antibiotics, decongestants and anti-allergic agents to no treatment. In this randomized, prospective, double-blind and controlled study the effect of a 14-day treatment (1–2 sprays into each nostril t.d.) with either isotonic Ems Mineral Salts (EMS) solution (Siemens & Co., Bad Ems, Germany) or xylometazoline solution (0.05%) was tested in children (n = 66) aged 2–6 years. Main outcomes: the degree of mucosal inflammation, nasal patency, general state of health, condition of the middle ear, auditory function as well as an assessm…

Intrakranielle Zyste in H�he des Os frontale

2003

Relevanz von Infektionskrankheiten in einer Kinderarztpraxis

1993

According to official statistics, infectious diseases only play a minor role in German children. To test this assumption, 1685/3405 charts of a private pediatrician were randomly chosen for further evaluation. 1112/1685 children had been seen in the office during the study period, 934 of them because of an infectious disease (83%). 700/934 charts were further reviewed in a standardized fashion. Pharyngo-tonsillitis was the most frequent diagnosis (18.6%), followed by (non-obstructive) bronchitis (18.5%), infectious diseases of the skin (10.2%) and Otitis media (9.9%). Typical "childhood diseases" (measles, mumps, rubella, varicella) only played a minor role. For some diseases age-specific a…

Seidlmayer’s purpura: five cases and review of the litterature

2014

About 100 cases of AHEI have been published in medical literature worldwide. Although initially considered a variant of Henoch-Schonlein purpura (HSP), it is now considered a separate entity: in fact it shows infrequently visceral involvement and IgA skin depositions. Furthermore these patients show a better prognosis than HSP patients. Onset age for AHEI usually ranges between 4 and 24 months but it spreads from birth to 60 months. AHEI, also defined Seidlmayer’s purpura (SP), is characterized by the triad: fever, oedema and purpura. The latter is usually rosette-, annular- or targeted-shaped primarily over the face, ears and extremities in a nontoxic infant. The development and the rapidi…

931 Intestinal Parasites in Internationally Adopted Children in Belgium

2012

Background and Aims 314 internationally adopted children were seen between 01/01/2008 and 31/03/2012 at the Institute of Tropical Medicine in Antwerp (Belgium). We describe the prevalence of pathogenic intestinal parasites in this population. Methods Retrospective analysis of patient records. Feces samples were obtained in 307/314 children. In addition, serology for Strongyloides and Schistosoma was performed. Results Pathogenic parasites were found in 55.7% (53% in children 0–5 years, 72.1% > 5years). When counting any parasites, 65.9% of children were found positive (61.4% for 0–5 years, 93% for >5 years). 37.5% of children with positive samples had ≥ 3 parasites. Analysis by age in child…

Parental informed consent in pediatric cancer trials: A population-based survey in Germany

2012

In Germany, nearly every child afflicted by a malignant dis-ease or a central nervous system tumor is enrolled in a clinicaltrial during treatment. Many of these children are under the age of5 years when they are first diagnosed [1]. The decision whether ornot to participate in a clinical trial is normally made by theparents on behalf of their child. Therefore, ensuring adequatelyinformed parental consent is essential to ethical practice in pedi-atric oncology.However, many empirical studies have revealed difficultieswith the informed consent process when parents are faced withthe decision to enroll their child in a clinical trial. Previous studyfindings have indicated that recalling signing th…

Extended pH-monitoring in the evaluation of gastroesophageal reflux in infancy and childhood

1986

Esophageal 24-h pH monitoring was performed in addition to esophagogastrography, esophageal manometry, and esophagoscopy in 66 infants and 12 children from 2–14 years of age with symptoms characteristic of gastroesophageal reflux (GER). In ten infants, ph monitoring was repeated once or twice at intervals of 1 week to 8 1/2 months. The follow-up time for all patients ranged from 2–7 years. Our findings suggest that extended pH monitoring is the most valuable diagnostic procedure under the following circumstances. First, when there are major discrepancies between reported observations and actual symptoms during hospitalization, pH monitoring can clarify the causal relationship. Second, when …