Search results for "periodontal"

Heat shock protein 70 dampens the inflammatory response of human PDL cells to mechanical loading in vitro

2019

BACKGROUND AND OBJECTIVE Previously, we demonstrated an inflammatory response of human PDL (hPDL) cells to mechanical loading. The cellular reaction was dampened by heat pre-treatment suggesting a protective role for heat shock proteins (HSP) during stress-induced ischemia. Here we explored if HSP70, which has already been documented in the pressure zone of tooth movement, might be regulatorily involved in the attenuation of the inflammatory response. MATERIALS AND METHODS Fifth passage hPDL cells were mechanically loaded in the presence of the HSP70 inhibitor VER155008. Cell morphology, HSP70 expression, viability, IL-6 and IL-8 expression were determined by means of microscopy, realtime-P…

Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner

2021

The WNT/β-catenin signaling pathway plays a central role in the biology of the periodontium, yet the function of specific extracellular WNT ligands remains poorly understood. By using a Wnt1-inducible transgenic mouse model targeting Col1a1-expressing alveolar osteoblasts, odontoblasts, and cementoblasts, we demonstrate that the WNT ligand WNT1 is a strong promoter of cementum and alveolar bone formation in vivo. We induced Wnt1 expression for 1, 3, or 9 wk in Wnt1Tg mice and analyzed them at the age of 6 wk and 12 wk. Micro–computed tomography (CT) analyses of the mandibles revealed a 1.8-fold increased bone volume after 1 and 3 wk of Wnt1 expression and a 3-fold increased bone volume aft…

2021

Orthodontic treatment to correct dental malocclusions leads to the formation of pressure zones in the periodontal ligament resulting in a sterile inflammatory reaction, which is mediated by periodontal ligament fibroblasts (PDLF). Leptin levels are elevated in obesity and chronic inflammatory responses. In view of the increasing number of orthodontic patients with these conditions, insights into effects on orthodontic treatment are of distinct clinical relevance. A possible influence of leptin on the expression profile of PDLF during simulated orthodontic mechanical strain, however, has not yet been investigated. In this study, PDLF were exposed to mechanical strain with or without differen…

The association of periodontal diseases with metabolic syndrome and obesity

2020

Periodontitis is a multifactorial chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth-supporting apparatus. Globally, it is estimated that 740 million people are affected by its severe form. Periodontitis has been suggested to be linked to obesity and metabolic syndrome. Obesity, defined as excessive fat accumulation, is a complex multifactorial chronic inflammatory disease, with a high and increasing prevalence. Metabolic syndrome is defined as a cluster of obesity, dyslipidemia, hypertension, and dysglycemia. Obesity, metabolic syndrome and periodontitis are among the most common non-communicable diseases and a l…

2020

As type-I-allergies show an increasing prevalence in the general populace, orthodontic patients may also be affected by histamine release during treatment. Human periodontal ligament fibroblasts (PDLF) are regulators of orthodontic tooth movement. However, the impact of histamine on PDLF in this regard is unknown. Therefore PDLF were incubated without or with an orthodontic compressive force of 2g/cm2 with and without additional histamine. To assess the role of histamine-1-receptor (H1R) H1R-antagonist cetirizine was used. Expression of histamine receptors and important mediators of orthodontic tooth movement were investigated. PDLF expressed histamine receptors H1R, H2R and H4R, but not H3…

Full arch fixed prostheses vs. full arch telescopic-retained retrievable prostheses both supported by implants and natural tooth abutments in periodo…

2019

Background The clinical outcome of full arch fixed prostheses vs. full arch telescopic-retained retrievable prostheses supported by implants and natural tooth abutments in periodontally treated patients has been reported by few studies, with controversial results. The objective of this study was to evaluate long-term (15 years) complications of abutment teeth and dental implants in periodontally treated patients, rehabilitated with full arch telescopic-retained retrievable prostheses (TRP)s vs. full arch fixed prostheses (FP)s supported by teeth and implants. Material and methods After active periodontal therapy (non-surgical and surgical), and implant placement (replacement of hopeless tee…

A comprehensive approach to assigning periodontal prognosis

2018

Abstract Aim The purpose of this retrospective case series study was to evaluate the usefulness and performance of a comprehensive approach to assigning periodontal prognosis by assessing the risk of tooth loss due to periodontal disease (TLPD) and estimate the survival time (ST) of periodontally compromised teeth (PCT). Material and Methods The Long‐Term Outcome (LTO) index was utilized to assess the risk of TLPD, at baseline, in 100 patients following periodontal maintenance for a mean 24.7 year (±2.4). A TLPD prediction model was utilized to assign ST to PCT. The performance of the TLPD prediction based on both parameters was assessed. Results The mean TLPD rate increased as the LTO inde…

Estudio de la enfermedad periodontal y la respuesta al tratamiento periodontal no-quirúrgico en pacientes obesos no-diabéticos: influencia del perfil…

2018

ESTUDIO DE LA ENFERMEDAD PERIODONTAL Y LA RESPUESTA AL TRATAMIENTO PERIODONTAL NO-QUIRÚRGICO EN PACIENTES OBESOS NO-DIABÉTICOS: INFLUENCIA DEL PERFIL METABÓLICO Y DE LA PÉRDIDA DE PESO. JUSTIFICACIÓN Y OBJETIVOS La obesidad es una enfermedad metabólica que cursa con un estado inflamatorio crónico de bajo grado, el cual puede incrementar la susceptibilidad a ciertas enfermedades inflamatorias orales como la enfermedad periodontal. La asociación entre obesidad y periodontitis ha sido establecida por múltiples estudios epidemiológicos por todo el mundo; sin embargo, el mecanismo biológico exacto de cómo la obesidad afecta al periodonto, todavía permanece incierto. Por otro lado, la respuesta a…

A combined treatment regimen for chronic desquamative gingivitis in patients with oral lichen planus

2007

Background: Chronic desquamative gingivitis (DG) is a condition characterized by erythema, ulceration, and desquamation of the free and attached gingiva, usually expression of a district-systemic disease, such as oral lichen planus (OLP). Methods: A combined protocol of oral hygiene and topic corticosteroid therapy was applied in 30 patients with DG associated with OLP. Plaque index (PI) and bleeding on probing (BoP) were evaluated at baseline and after 3 months. Results: PI scoring was significantly lower after treatment in anterior, posterior, and all sites (P < 0.0001) as well as in vestibular and lingual ones (P < 0.0001 and P = 0.0001, respectively). BoP measures were found to be reduc…

Periodontal morphological microcirculation in Oral Lichen Planus

2008

This study aimed at evaluating possible differences in the vascular pattern (of periodontal mucosa microcirculation) between healthy patients and patients suffering from PLP (periodontal lichen planus). Fifty-four patients (27 patients suffering from PLP and 27 healthy patients) were examined by means of videocapillaroscopy. The following area was examined for each patient: periodontal mucosa corresponding to 1.1 and 2.1. The following parameters were analyzed on every capillaroscopic image: capillary loop length, loop diameter, capillary tortuosity, capillary density, avascular areas, possible microhaemorrhages, distinctive morphology. The results obtained using videocapillaroscopic softwa…