Search results for "pero"
showing 5 items of 3365 documents
Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles.
2004
ABSTRACT Recent reports suggest that nuclear domain(s) 10 (ND10) is the site of papillomavirus morphogenesis. The viral genome replicates in or close to ND10. In addition, the minor capsid protein, L2, accumulates in these subnuclear structures and recruits the major capsid protein, L1. We have now used cell lines deficient for promyelocytic leukemia (PML) protein, the main structural component of ND10, to study the role of this nuclear protein for L2 incorporation into virus-like particles (VLPs). L2 expressed in PML protein knockout (PML −/− ) cells accumulated in nuclear dots, which resemble L2 aggregates forming at ND10 in PML protein-containing cells. These L2 assemblies also attracted…
Teacher-child interaction quality and children's self-regulation in toddler classrooms in Finland and Portugal
2021
This study examines the association between teacher–child interaction quality and children's self‐regulation in Finnish and Portuguese toddler classrooms. The participants included 230 Finnish (M = 29; SD = 3 months) and 283 Portuguese (M = 30, SD = 4 months) toddlers and their teachers (n = 43 Finland; n = 29 Portugal). The children's behavioural self‐regulation (attention, working memory, and inhibition control) was individually tested, and the teachers evaluated the children's self‐regulation skills in the classroom. The quality of the teacher–child interactions (i.e., emotional and behavioural support and engaged support for learning) was evaluated using the CLASS‐Toddler observation in…
The mitogen-activated protein kinase p38 pathway is conserved in metazoans: Cloning and activation of p38 of the SAPK2 subfamily from the sponge Sube…
2000
Our recent data suggest that during auto- and allograft recognition in sponges (Porifera), cytokines are differentially expressed. Since the mitogen-activated protein kinase (MAPK) signal transduction modulates the synthesis and release of cytokines, we intended to identify one key molecule of this pathway. Therefore, a cDNA from the marine sponge Suberites domuncula encoding the MAPK was isolated and analyzed. Its encoded protein is 366 amino acids long (calculated Mr 42 209), has a TGY dual phosphorylation motif in protein kinase subdomain VIII and displays highest overall similarity to the mammalian p38 stress activated protein kinase (SAPK2), one subfamily of MAPKs. The sponge protein w…
Pienten lasten osallisuus vuorohoidon iltojen vuorovaikutustilanteissa
2021
Tutkimuksessa tarkastellaan, kuinka pienten lasten osallisuus toteutuu vuorohoidon iltojen vuorovaikutustilanteissa ja millaisia haasteita tähän liittyy. Aineisto kerättiin havainnoimalla 20–36 kk ikäisten lasten iltoja kahdessa erilaisessa vuoropäiväkodissa. Temaattisen analyysin perustana toimivat Lundyn (2007) kuvaamat, Yhdistyneiden Kansakuntien (YK) lapsen oikeuksien sopimuksen artiklaan 12 pohjautuvat lasten osallisuuden edellytykset. Huomion kohteena olivat erityisesti työntekijöiden toiminta ja sen lapsille luomat mahdollisuudet ilmaista mielipiteitään sekä tulla kuulluksi ja huomioiduksi. Muuttuva iltaryhmä sekä päiväkodin rutiinit ja säännöt rajoittivat toisinaan lasten osallisuud…
Čukstošas galerijas modas rezonatoru temperatūras sensors
2019
Čukstošo galerijas modu (ČGM) rezonatori ir sfēriskas formas objekti, kas ir taisīti no optiski caurspīdīgiem materiāliem un ir spējīgi uzturēt optiski cirkulējošu vilni iekšā sfērā, izmantojot pilnīgu iekšējo atstarošanos. Ja ir monohromātisks gaismas avots ar konstantu intensitāti, tad vilnis, kas kustās pa lodes perimetru, sāk konstruktīvi interferēt. Šajā gadījumā rodas rezonanse, ko sauc par čukstošo galeriju modu (ČGM), pēc analoģijas no akustikas. Darbā tiek aplūkots koncepts, ka ČGM rezonatorus varētu izmantot kā temperatūras sensorus. Izmantojot dažāda lieluma rezonatorus un mainot tempratūru, tiek testēta sistēma un rezonanses. Darbā tiek veidota praktiska sistēma ar kuras palīdzī…