Search results for "pharmaceutical"
showing 10 items of 3243 documents
Bright spots in the darkness of cancer: A review of starfishes-derived compounds and their anti-tumor action
2019
The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable. Oceans, due to their wide diversity of marine species and environmental conditions have proven to be precious sources of potential natural drugs with active properties. As an example, in this context several studies performed on sponges, tunicates, mollusks, and soft corals have brought evidence of the interesting biological activities of the molecules derived from these species. Also, echinoderms constitute an important phylum, whose members produce a huge number of compounds with diverse biological activities. In…
Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates
2020
The collective migration of cells is a complex integrated process that represents a common theme joining morphogenesis, tissue regeneration, and tumor biology. It is known that a remarkable amount of secondary metabolites produced by aquatic invertebrates displays active pharmacological properties against a variety of diseases. The aim of this review is to pick up selected studies that report the extraction and identification of crude extracts or isolated compounds that exert a modulatory effect on collective cell locomotion and/or skin tissue reconstitution and recapitulate the molecular, biochemical, and/or physiological aspects, where available, which are associated to the substances und…
La reputación como ventaja competitiva sostenible
2019
En los actuales contextos globalizados, las empresas se encuentran en una búsqueda incesante por diferenciarse. La oferta de bienes y servicios en general ha crecido, tanto en cantidad como en calidad. A tal grado se produce este fenómeno que, si la empresa no encuentra una buena razón (y la comunica correctamente) para ser elegida por los consumidores, se condena a perder mercado y/o rentabilidad. Las tradicionales fuentes de ventaja competitiva se encuentran sobreexplotadas. Además de presentar problemas con su sostenibilidad. En principio, es necesario definir la reputación corporativa y diferenciarla de otros conceptos con los cuales se relaciona. Con esta base, se procederá a referirse…
Biopiracy in India: Seed diversity and the scramble for knowledge.
2018
Abstract Background: Biopiracy has usually been discussed mostly in the context of the life sciences, sometimes in dialogue with legal debates or political implications. This paper provides a humanities perspective on contemporary discussions of biopiracy and biopatenting. Hypothesis It proceeds from the hypothesis that contemporary debates and practices of biopiracy can be understood as harking back to colonial legacies, which systematically disregard “native” knowledge or seek to appropriate it for their own purposes. Results Drawing on the work of Vandana Shiva, the present article seeks to redefine the notion of ownership of knowledge from a cultural studies perspective. Exploring the 2…
Evaluación del riesgo en humedales costeros mediterráneos de la presencia de contaminantes químicos orgánicos = Evaluation of the risk in Mediterrane…
2008
El rápido incremento de la población urbana ha traído asociado una intensa presión en el medioambiente circundante. Actualmente, la franja costera en la mayoría de países europeos es el área que ha experimentado un mayor desarrollo socioeconómico. Algunas pinceladas obtenidas de distintas fuentes dan una idea global de la importancia del crecimiento demográfico de estas zonas. Hoy en día, 3 mil millones de personas –alrededor de la mitad de la población mundial- viven a menos de 200 kilómetros de la costa. Dos quintas partes de las ciudades con poblaciones de entre 1 y 10 millones están localizadas cerca de la costa. En Bélgica, Portugal y España, la densidad de población en los 10 kilómetr…
Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 18. Mitt. Absolute Konfiguration und histaminartige Wirkung der Enantiomere von 5-Amino-4,5,6,7-te…
1979
Es werden die Racemattrennung von 5-Amino-4,5,6,7-tetrahydro-benzimidazol (3), die Bestimmung der absoluten Konfiguration sowie die histaminartige Wirksamkeit der Enantiomere am Ileum (H1) und Atrium (H2) des Meerschweinchens beschrieben. Structure-Activity Relationship of Histamine Analogues, XVIII: Absolute Configuration and Histamine-like Activity of the Enantiomers of 5-Amino-4,5,6,7-tetrahydrobenzimidazole The resolution of 5-amino-4,5,6,7-tetrahydrobenzimidazole (3), the determination of the absolute configuration and the histamine-like activity of the enantiomers on the guinea-pig ileum (H1) and atrium (H2) are reported.
Äther und Ester des 4-(2-Hydroxyaethyl)-imidazols und Ester der 4-Imidazolpropionsäure 4. Mitt. über Struktur-Wirkungs-Beziehungen bei Histaminanaloga
1974
Als potentiell histaminartig wirksame Substanzen wurden Ather und Ester des 4-(2-Hydroxyaethyl)-imidazols und Ester der 4-Imidazolpropionsaure dargestellt und am isolierten Ileum des Meerschweinchens und anderen Testobjekten untersucht. Ethers and Esters of 4-(2-Hydroxyethyl)-imidazole and Esters of 4-Imidazolepropionic Acid As substances with possible histamine-like activity, ethers and esters of 4-(hydroxyethyl)-imidazole and esters of 4-imidazolepropionic acid are prepared and tested on isolated guinea pig ileum and other objects.
Ester des 4-Hydroxymethyl-imidazols und der 4-Imidazolessigsäure 2. Mitt. über Struktur-Wirkungs-Beziehungen bei Histaminanaloga
1974
Als potentiell histaminartig wirksame Substanzen wurden Ester des 4-Hydroxymethyl-imidazols und der 4-Imidazolessigsaure dargestellt und am isolierten Ileum des Meerschweinchens und anderen Testobjekten untersucht. Esters of 4-Hydroxymethylimidazole and 4-Imidazoleacetic Acid As substances with possible histamine-like activity esters of 4-hydroxymethylimidazole and 4-imidazoleacetic acid were prepared and tested on isolated guinea-pig ileum and other objects.
Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids fromDiospyros leucomelas*
1995
Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D, and cycloheximide has served to determine the mechanism of action in relationship with that of glucocorticoids. Betulinic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.
Cinnamaldehyde Induces Expression of Efflux Pumps and Multidrug Resistance in Pseudomonas aeruginosa
2019
Essential oils or their components are increasingly used to fight bacterial infections. Cinnamaldehyde (CNA), the main constituent of cinnamon bark oil, has demonstrated interesting properties in vitro against various pathogens, including Pseudomonas aeruginosa. In the present study, we investigated the mechanisms and possible therapeutic consequences of P. aeruginosa adaptation to CNA. Exposure of P. aeruginosa PA14 to subinhibitory concentrations of CNA caused a strong albeit transient increase in the expression of operons that encode the efflux systems MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY/OprM. This multipump activation enhanced from 2- to 8-fold the resistance (MIC) of PA14 to …