Search results for "phenomena"
showing 10 items of 8379 documents
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives
2020
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical com…
r Process (n, γ) Rate Constraints from the γ Emission of Neutron Unbound States in β decay
2017
Total absorption gamma-ray spectroscopy is used to measure accurately the intensity of γγ emission from neutron-unbound states populated in the ββ-decay of delayed-neutron emitters. From the comparison of this intensity with the intensity of neutron emission a constraint on the (n, γγ) cross section for highly unstable neutron-rich nuclei can be deduced. A surprisingly large γγ branching was observed for a number of isotopes which might indicate the need to increase by a large factor the Hauser-Feshbach (n, γγ) cross-section estimates that impact on r process abundance calculations. peerReviewed
Service Climate and Display of Employees’ Positive Emotions: The Mediating Role of Burnout and Engagement in Services
2011
This article aims to test a model linking service climate to the frequency of expression of positive emotions by frontline employees. We propose that burnout and engagement at work mediate the relationship between service climate and the expression of positive emotions. Service climate impacts negatively on burnout and positively on engagement; in turn, burnout and engagement are significantly related to the frequency of expression of positive emotions. This model was tested both at the individual and work-unit levels. In addition, it was compared with a direct model that proposes an additional direct link from service climate to frontline employees’ positive emotions. Models were tested th…
Improving the Effect of Transcranial Alternating Current Stimulation (tACS): A Systematic Review
2021
With the development of electrical stimulation technology, traditional transcranial alternating current stimulation (tACS) technology has been found to have the drawback of not targeting a specific area accurately. Studies have shown that optimizing the number and position of electrodes during electrical stimulation has a very good effect on enhancing brain stimulation accuracy. At present, an increasing number of laboratories have begun to optimize tACS. However, there has been no study summarizing the optimization methods of tACS. Determining whether different optimization methods are effective and the optimization approach could provide information that could guide future tACS research. …
Three-dimensional core-collapse supernovae with complex magnetic structures: I. Explosion dynamics
2021
Magnetic fields can play a major role in the dynamics of outstanding explosions associated to violent events such as GRBs and hypernovae, since they provide a natural mechanism to harness the rotational energy of the central proto-neutron star and power relativistic jets through the stellar progenitor. As the structure of such fields is quite uncertain, most numerical models of MHD-driven core-collapse supernovae consider an aligned dipole as initial magnetic field, while the field's morphology can actually be much more complex. We present three-dimensional simulations of core-collapse supernovae with more realistic magnetic structures, such as quadrupolar fields and, for the first time, an…
The impact of non-dipolar magnetic fields in core-collapse supernovae
2019
The magnetic field is believed to play an important role in at least some core-collapse supernovae if its magnitude reaches $10^{15}\,\rm{G}$, which is a typical value for a magnetar. In the presence of fast rotation, such a strong magnetic field can drive powerful jet-like explosions if it has the large-scale coherence of a dipole. The topology of the magnetic field is, however, probably much more complex with strong multipolar and small-scale components and the consequences for the explosion are so far unclear. We investigate the effects of the magnetic field topology on the dynamics of core-collapse supernovae and the properties of forming proto-neutron star (PNS) by comparing pre-collap…
Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy
2015
ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.
Discovery of an Exceptionally Strong β -Decay Transition of $^{20}$F and Implications for the Fate of Intermediate-Mass Stars
2019
A significant fraction of stars between 7-11 solar masses are thought to become supernovae, but the explosion mechanism is unclear. The answer depends critically on the rate of electron capture on $^{20}$Ne in the degenerate oxygen-neon stellar core. However, due to the unknown strength of the transition between the ground states of $^{20}$Ne and $^{20}$F, it has not previously been possible to fully constrain the rate. By measuring the transition, we have established that its strength is exceptionally large and enhances the capture rate by several orders of magnitude. This has a decisive impact on the evolution of the core, increasing the likelihood that the star is (partially) disrupted b…
Search for photons with energies above 1018 eV using the hybrid detector of the Pierre Auger Observatory
2017
A search for ultra-high energy photons with energies above 1 EeV is performed using nine years of data collected by the Pierre Auger Observatory in hybrid operation mode. An unprecedented separation power between photon and hadron primaries is achieved by combining measurements of the longitudinal air-shower development with the particle content at ground measured by the fluorescence and surface detectors, respectively. Only three photon candidates at energies 1-2 EeV are found, which is compatible with the expected hadron-induced background. Upper limits on the integral flux of ultra-high energy photons of 0.027, 0.009, 0.008, 0.008 and 0.007 km-2 sr-1 yr-1 are derived at 95% C.L. for ener…
Ultra-High Energy Neutrinos at the Pierre Auger Observatory
2013
The observation of ultrahigh energy neutrinos (UHE nu s) has become a priority in experimental astroparticle physics. UHE nu s can be detected with a variety of techniques. In particular, neutrinos can interact in the atmosphere (downward-going nu) or in the Earth crust (Earth-skimming nu), producing air showers that can be observed with arrays of detectors at the ground. With the surface detector array of the Pierre Auger Observatory we can detect these types of cascades. The distinguishing signature for neutrino events is the presence of very inclined showers produced close to the ground (i.e., after having traversed a large amount of atmosphere). In this work we review the procedure and …