Search results for "physiology"
showing 10 items of 8671 documents
Panic disorder, anxiety, and cardiovascular diseases
2014
Different data indicate that psychological and/or emotional disorders may play an important role in the natural history of heart diseases. Although the major evidence is that related to depression, epidemiological data would indicate that anxiety and panic disorders are highly represented in cardiac patient, thus influencing mortality and morbidity. The diagnosis of panic disorder in patients with chest pain is crucial to a correct therapeutic approach, as well as to reduce the risks and costs of inappropriate treatments. Anxiety and panic may accelerate different direct and indirect processes involved in the pathogenesis of cardiovascular diseases: lifestyle risk factors, arterial hyperten…
Hormesis: Decoding Two Sides of the Same Coin
2015
In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how t…
New Insights Into Causal Pathways Between the Pediatric Age-Related Physical Activity Decline and Loss of Control Eating: A Narrative Review and Prop…
2020
Research consistently suggests that loss of control (LOC) eating in children and adolescents is a key factor contributing to pediatric obesity and eating disorders. However, causes of pediatric LOC eating are yet unclear, and there is a lack of longitudinal research investigating the developmental processes contributing to LOC eating and related outcomes in youth. Physical activity is an understudied behavior that declines during middle childhood to adolescence and may exert an influence in the development of LOC eating via its impact on executive functioning. While physical activity levels and executive functioning have been linked to regulation of eating, no research has examined the mech…
Production and Characterization of Medium-Sized and Short Antioxidant Peptides from Soy Flour-Simulated Gastrointestinal Hydrolysate.
2021
Soybeans (Glycine max) are an excellent source of dietary proteins and peptides with potential biological activities, such as antihypertensive, anti-cholesterol, and antioxidant activity
The micro-macro link in understanding sport tactical behaviours: Integrating information and action at different levels of system analysis in sport
2015
Les liens micro-macroscopiques sont centraux dans les sciences du mouvement humain dans la mesure ou ils correspondent aux coordinations et aux echelonnages des comportements moteurs a differents niveaux d’analyse des systemes complexes. Cet aspect de la complexite est un point cle permettant de considerer decision et action comme un comportement de transition a differents niveaux lors de la realisation d’une performance. Les transitions exprimees en termes de bifurcations sont une part importante du mecanisme universel de decision. Les transitions de phase fournissent aussi un moyen de comprendre les liens micro-macro. Dans cet article de synthese, nous developpons un point de vue qui expl…
The micro-macro link in understanding sport tactical behaviours: Integrating information and action at different levels of system analysis in sport
2015
The micro-macro link is a central issue of human movement sciences because it directly refers to coordination and scalability of movement behaviour at different levels of analysis in a complex system. This feature of complexity is a key feature to consider decisions and actions as transitional behaviours at different levels during performance. Transitions expressed through bifurcations are an important part of a universal decisionmaking process. Here we explain how individuals perform decision-making behaviours in a minimal social performance unit ( competing dyads), and how these two levels are linked in a sports team. Finally we discuss some applications of the micro-macro links for the d…
Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcoh…
2020
Perinatal alcohol exposure affects ontogenic neurodevelopment, causing physical and functional long-term abnormalities with limited treatment options. This study investigated long-term consequences of continuous and intermittent maternal alcohol drinking on behavioral readouts of cognitive function and alcohol vulnerability in the offspring. The effects of environmental enrichment (EE) during adolescence were also evaluated. Female rats underwent continuous alcohol drinking (CAD)—or intermittent alcohol drinking paradigm (IAD), along pregestation, gestation, and lactation periods—equivalent to the whole gestational period in humans. Male offspring were reared in standard conditions or EE un…
Ontogenetic δ15N Trends and Multidecadal Variability in Shells of the Bivalve Mollusk, Arctica islandica
2021
Bulk stable nitrogen isotope values of the carbonate-bound organic matrix in bivalve shells (δ15NCBOM) are increasingly used to assess past food web dynamics, track anthropogenic nitrogen pollution and reconstruct hydrographic changes. However, it remains unresolved if the δ15NCBOM values are also affected by directed ontogenetic trends which can bias ecological and environmental interpretations. This very aspect is tested here with modern and fossil specimens of the long-lived ocean quahog, Arctica islandica, collected from different sites and water depths in the NE Atlantic Ocean. As demonstrated, δ15NCBOM values from the long chronologies show a general decrease through lifetime by −0.00…
Intergenerational Effect of Early Life Exposure to Permethrin: Changes in Global DNA Methylation and in Nurr1 Gene Expression
2015
Environmental exposure to pesticides during the early stages of development represents an important risk factor for the onset of neurodegenerative diseases in adult age. Neonatal exposure to Permethrin (PERM), a member of the family of synthetic pyrethroids, can induce a Parkinson-like disease and cause some alterations in striatum of rats, involving both genetic and epigenetic pathways. Through gene expression analysis and global DNA methylation assessment in both PERM-treated parents and their untreated offspring, we investigated on the prospective intergenerational effect of this pesticide. Thirty-three percent of progeny presents the same Nurr1 alteration as rats exposed to permethrin i…
Can Oscillatory Alpha-Gamma Phase-Amplitude Coupling be Used to Understand and Enhance TMS Effects?
2019
Recent applications of simultaneous scalp electroencephalography (EEG) and transcranial magnetic stimulation (TMS) suggest that adapting stimulation to underlying brain states may enhance neuroplastic effects of TMS. It is often assumed that longer-lasting effects of TMS on brain function may be mediated by phasic interactions between TMS pulses and endogenous cortical oscillatory dynamics. The mechanisms by which TMS exerts its neuromodulatory effects, however, remain unknown. Here, we discuss evidence concerning the functional effects on synaptic plasticity of oscillatory cross-frequency coupling in cortical networks as a potential framework for understanding the neuromodulatory effects o…