Search results for "pikornavirukset"

showing 2 items of 2 documents

Integrin-mediated entry of echovirus 1

2008

Paula Upla selvitti väitöskirjassaan echovirus 1:n solunsisäistä reittiä ja tunnisti solurakenteita ja säätelijöitä, jotka ovat tärkeitä infektiossa. Echovirus 1 (EV1) kuuluu pikornavirusperheeseen, jonka muita tunnettuja edustajia ovat poliovirus sekä karjan suu- ja sorkkatautivirus. EV1 on pieni (25-30 nm), vaipaton RNA-virus. EV1 aiheuttaa useimmiten oireettomia tai vähäoireisia suolisto- ja hengitystieinfektioita, mutta myös vakavampia tiloja, kuten aivokalvontulehdusta.Upla seurasi viruksen tunkeutumista soluun käyttäen elektronimikroskopiaa sekä tehokasta kolmi- ja neliulotteista konfokaalimikroskopiaa. Näin hän pystyi havainnoimaan yhtä aikaa usean eri molekyylin vuorovaikutusta niih…

echovirus 1solutintegriinitreseptoritviruksetpikornaviruksetRNA

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Regulation of raft-derived endocytic pathways : studies on echovirus 1 and baculovirus

2009

Elina Kakkonen tutki väitöskirjassaan kahden erilaisen viruksen, echovirus 1:n ja bakuloviruksen soluun sisäänmenon reittejä ja säätelijöitä. Echovirus 1 (EV1) on ihmisiä infektoiva pikornavirus, joka voi aiheuttaa esimerkiksi aivokalvontulehdusta, sydänlihastulehdusta sekä lievempiä hengitystieinfektioita. Bakulovirus puolestaan on ihmisille vaaraton, hyönteisiä infektoiva virus, joka on osoittautunut lupaavaksi geeninsiirtokuljettajaksi geeniterapiassa.Virukset voivat käyttää soluun tunkeutumisessaan hyväkseen soluissa valmiina olevia erilaisia reittejä, joita solut itse tarvitsevat esimerkiksi ravintoaineiden sisäänottoon. Näin virukset pääsevät solun sisälle solun oman koneiston kuljett…

lipid raftsregulatorsviruksetpikornaviruksetcholesterolinfektiotCtBP1/BARSechovirus 1enteroviruksetbaculovirusbakuloviruksetendocytosisechoviruksetsolubiologia

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PEPhysical Sciences and Engineering
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LSLife Sciences
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