Search results for "pine"
showing 10 items of 2022 documents
Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction.
2010
N-substituted benztropine (BZT) analogs are molecules that display high affinity for the dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and psychopharmacological characteristics consistent with those of a substitute medication for cocaine addiction. Since amphetamine (Amph) and cocaine share mechanisms of action at the DAT, we evaluated the effectiveness of a BZT analog in animal models of Amph addiction. We tested in mice and rats the effects of the BZT derivative, 3α-[bis(4-fluorophenyl)methoxy]-tropane (AHN-1055), on Amph-induced conditioned place preference (CPP), locomotor activity, sensitization, self-administration and ΔFosB accumulation in th…
A new type of autosomal recessive spondyloepiphyseal dysplasia tarda
2004
Repeated occurrence of a hitherto unrecognized form of spondyloepiphyseal dysplasia tarda (SED tarda) has been studied in two independent families. Because parental consanguinity was also present in one family, autosomal recessive inheritance is proposed. The onset was in late childhood. The slowly evolving disorder shared several features of the already known types of SED tarda. The radiographic abnormalities were limited to the spine and proximal femora. The patients' hands were normal. The entity described is set apart not only from the X-linked and autosomal-dominant forms of SED tarda but also from the already delineated autosomal recessive types by significant clinical and radiographi…
Automatic segmentation of the spine by means of a probabilistic atlas with a special focus on ribs suppression. Preliminary results
2015
Spine is a structure commonly involved in several prevalent diseases. In clinical diagnosis, therapy, and surgical intervention, the identification and segmentation of the vertebral bodies are crucial steps. However, automatic and detailed segmentation of vertebrae is a challenging task, especially due to the proximity of the vertebrae to the corresponding ribs and other structures such as blood vessels. In this study, to overcome these problems, a probabilistic atlas of the spine, including cervical, thoracic and lumbar vertebrae has been built to introduce anatomical knowledge in the segmentation process, aiming to deal with overlapping gray levels and the proximity to other structures. F…
Effects and underlying mechanisms of unstable shoes on chronic low back pain : a randomized controlled trial
2018
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://journals.sagepub.com/doi/abs/10.1177/0269215517753972?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=crea Este es el postprint del siguiente artículo: Lisón, JF., Ortega-Santana, B., Antón-Nogués, Á., González-Requena, P., Vera-Hervás, C., Doménech-Fernández, J. et al. (2018). Effects and underlying mechanisms of unstable shoes on chronic low back pain : a randomized controlled trial. Clinical Rehabilitationol. 32, n. 5 (may), pp. 654-662, que se ha publicado de forma definitiva en https://doi.org/10.1177/0269215517753972 This is the pre-peer reviewed ve…
Muscle Activity Adaptations to Spinal Tissue Creep in the Presence of Muscle Fatigue.
2016
Aim The aim of this study was to identify adaptations in muscle activity distribution to spinal tissue creep in presence of muscle fatigue. Methods Twenty-three healthy participants performed a fatigue task before and after 30 minutes of passive spinal tissue deformation in flexion. Right and left erector spinae activity was recorded using large-arrays surface electromyography (EMG). To characterize muscle activity distribution, dispersion was used. During the fatigue task, EMG amplitude root mean square (RMS), median frequency and dispersion in x- and y-axis were compared before and after spinal creep. Results Important fatigue-related changes in EMG median frequency were observed during m…
Components and connections of the circadian timing system in mammals
1996
The circadian timing system is a neural network consisting of the hypothalamic suprachiasmatic nucleus, aided by the retina, other hypothalamic nuclei, autonomic regions of the spinal cord, sympathetic ganglia and the pineal gland. Extensive studies conducted over the last two decades have unravelled the principal items of its functional neuroanatomy. The system is responsible for the generation of the circadian rhythm, its synchronization by environmental factors such as light, and its mediation with respect to morphological, physiological and biochemical parameters of mammals that exhibit distinct alterations throughout the 24-h cycle. This review characterizes the brain sites involved an…
Rational Choice Theory and the Environment: Variants, Applications, and New Trends
2010
Rational choice theory (RCT) is a research paradigm based on methodological individualism. Collective phenomena are explained by assumptions about the behavior of (subjectively) rational individual or corporate actors. In environmental research, RCT is used to predict ecological perceptions, attitudes and behavior on the micro level, and to shed light on environmental outcomes on the macro level. The most fundamental insight from RCT is that environmental problems are often the result of a social dilemma, that is, individuals’ purposive action leads to unintended negative collective consequences. This chapter addresses variants of RCT including game theory, shows applications in the field o…
On Martial Law at 50 : Fact-Checking the Marcos Story, Countering the EDSA History
2022
To fact-check and counter the historical denialism of the Marcos family, there is need for a counterfactual history analysis of the failings of the 1986 EDSA People Power Revolution. nonPeerReviewed
Cueva Antón: A multi-proxy MIS 3 to MIS 5a paleoenvironmental record for SE Iberia
2016
Overlying a palustrine deposit of unknown age (complex FP), and protected from weathering and erosion inside a large cave/rock-shelter cavity, the sedimentary fill of Cueva Antón, a Middle Paleolithic site in SE Spain, corresponds in most part (sub-complexes AS2-to-AS5) to a ca.3 m-thick Upper Pleistocene terrace of the River Mula. Coupled with the constraints derived from the deposit’s paleoclimatic proxies, OSL dating places the accumulation of this terrace in MIS 5a, and radiocarbon dates from the overlying breccia cum alluvium (sub-complex AS1) fall in the middle part of MIS 3; the intervening hiatus relates to valley incision and attendant erosion. The two intervals represented remain …
The human side of leadership: Inspirational leadership effects on follower characteristics and happiness at work (HAW)
2020
Abstract Leadership has received significant attention over the past years. Now is the time to refine how leaders impact on followers and their attitudes. This study examines how inspirational leaders influence follower characteristics (FC), and in turn, their happiness at work. In this study, the mediating effect of follower characteristics in the relationship between inspirational leadership and happiness at work was specifically examined. Data was gathered from 389 frontline banking employees working in Italian and Spanish banks. A confirmatory factor analysis revealed a positive partial mediating role of follower characteristics in the relationship between inspirational leadership and h…