Search results for "pine"
showing 10 items of 2022 documents
The Italian observational study on severe osteoporosis (ISSO): 24-month results on incidence of fractures and adherence to treatment
2016
Objective To estimate the proportion of patients with very severe osteoporosis (those covered by the reimbursement criteria of the Italian National Health Service) experiencing new vertebral and non-vertebral fragility fractures in the first 24 months of a new anti-osteoporosis treatment. Methods Prospective observational study in men and post-menopausal women (aged > 21 years) initiating anti-osteoporosis treatment for very severe osteoporosis. Eligibility was based on teriparatide (TPD) reimbursement criteria in Italy: Incident of vertebral or hip fracture during anti-resorptive treatment (minimum 1 year), or at least three prevalent severe vertebral fractures, or two prevalent severe ver…
Machaeracanthus goujetin. sp. (Acanthodii) from the Lower Devonian of Spain and northwest France, with special reference to spine histology
2012
ABSTRACT We describe here a new machaeracanthid acanthodian (Machaeracanthus goujeti n. sp.), based on isolated spines, scales and scapulocoracoids from the Lower Devonian (Lochkovian-Pragian) of the Nogueras Formation, Celtiberia, Spain. The new taxon also includes a fragmentary spine and isolated scales from the Lower Devonian of northern Spain (Palencia and Cantabrian Mountains) and western France (Saint-Cenere) originally assigned to Machaeracanthus sp. The spines of M. goujeti n. sp. comprise two morphotypes in agreement with the morphofunctional model of a pair of pectoral spines articulating with the pectoral girdle already indicated for M. hunsrueckianum Sudkamp & Burrow, 2007, M. l…
Influence of complex physiotherapy on the functional condition of the spine in older people
2018
The aim of the present study was to assess the impact of 21-days comprehensive physiotherapy program on the functional condition of the spine and severity of pain in older people. To achieve this goal, physiotherapeutic procedures were performed on 100 elderly patients suffering from spinal disorders. The comprehensive therapy program consisted of: general improvement exercises, individual exercises with a physiotherapist, exercises in water and physical therapy treatments such as: TENS currents, galvanic current, iontophoresis, laser stimulation, magnetic field on the lumbar spine and hydro massage or mud compresses. Prior and post the therapy program: the Schober’s test - 1 (forward flexi…
MRI evaluation of spine abnormalities in the supine position and under physiological load in athletes with a dedicated MR scanner
2013
Purpose of our study was to evaluate the behavior of the lumbar spine of young athletes in the supine and standing position, taking into account all postural changes that the spine undergoes during physiological load, any alterations and any discrepancies in the detection of pathology between the two positions. Between August 2008 and October 2009, we evaluated 40 sportsman (20 men and 20 women) with symptoms of lumbar pain. All subjects underwent MRI with a dedicated scanner of 0.25 Tesla (G-Scan, Esaote Biomedica, Genoa, Italy) either in the conventional supine position, either in the weight-bearing position. Spin echo T1w and fast spin echo T2w images were acquired with a dedicated recei…
Defects induced by He+ irradiation in γ-Si3N4
2021
International audience; Formation and evolution of defect levels in the electronic structure of silicon nitride with cubic spinel structure, -Si 3 N 4 , after the irradiation with He + ions was investigated using spectroscopic techniques. Strong changes of cathodoluminescence (CL), photoluminescence (PL), photoluminescence excitation (PLE) and Raman spectra were detected. In particular, excitonic PL was significantly inhibited and a new near-IR band appeared with the band gap excitation h≥E g =5.05 eV. This was explained by an effective trapping of photoinduced electrons and holes by charged defects. The spectral shift of PL with the excitation photon energy indicated heterogeneous nature…
Garnet and spinel lherzolite assemblages in MgO-Al2O3-SiO2 and CaO-MgO-Al2O3-SiO2: thermodynamic models and an experimental conflict
2012
The recent publication of an updated thermodynamic dataset for petrological calculations provides an opportunity to illustrate the relationship between experimental data and the dataset, in the context of a new set of activity–composition models for several key minerals. These models represent orthopyroxene, clinopyroxene and garnet in the system CaO–MgO–Al2O3–SiO2 (CMAS), and are valid up to 50 kbar and at least 1800 °C; they are the first high-temperature models for these phases to be developed for the Holland & Powell dataset. The models are calibrated with reference to phase-relation data in the subsystems CaO–MgO–SiO2 (CMS) and MgO–Al2O3–SiO2 (MAS), and will themselves form the basis o…
Altiero Spinelli e Alcide De Gasperi: due opposte fedi e una stessa idea d'Europa.
2008
Un parallelismo tra Altiero Spinelli e Alciide De Gasperi, due uomini politici di confessione religiosa e di afferenza partitica diverse, ma saldamente uniti dal comune ideale europeista, per la realizzazione del quale collaborarono da veri federalisti.
Characterization of the binding of benzodiazepines to human serum albumin
1973
The binding of eleven benzodiazepine derivatives to human serum albumin (HSA) was determined by means of sephadex gel filtration. The albumin binding of the substances was characterized by the percentage of bound drug, the binding constants k +, K 1 and m, the number of binding sites per albumin molecule, and the free binding energy. Under the conditions chosen in these experiments there seems to exist only one binding site of the same type for all investigated benzodiazepines at the HSA molecule. The affinities of the benzodiazepines to this binding site are very different. It is discussed which part of the benzodiazepine molecule represents the main binding group.
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter
2001
6-Methoxylated and 8-oxygenated benztropines were prepared and evaluated for their DAT and SERT activity (binding and uptake inhibition). Methoxylation at the two-carbon bridge of benztropine produced a novel class of potent and selective DAT ligands. An interesting enantioselectivity was also observed for this new class of chiral benztropines. The inactivity of the 8-oxygenated analogues seems to point out that, unlike cocaine and its analogues, interactions of benztropine ligands with DAT may be strongly governed by the nitrogen atom.
Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopami…
2005
A series of 6alpha- and 6beta-substituted benztropines were synthesized. A marked enantioselectivity was observed for the 6beta-methoxylated benztropines, the (1R)-isomers being more potent than the corresponding (1S) compounds. The racemic 6alpha-methoxy-3-(4',4' '-difluorodiphenylmethoxy)tropane (5 g) was the most potent compound. It has been found that modifications at the 6-position of benztropine might reduce the DAT binding affinity, maintaining otherwise a significant dopamine uptake inhibitory activity. A reinvestigation of the absolute configuration of 6beta-methoxytropinone proved the 6R configuration for the (+)-enantiomer.