Search results for "pine"

showing 10 items of 2022 documents

Automated Determination of Ziprasidone by HPLC With Column Switching and Spectrophotometric Detection

2005

An isocratic high-performance liquid chromatography (HPLC) method with column switching and ultraviolet (UV) detection is described for quantitative analysis of the new antipsychotic drug ziprasidone. After centrifugation of serum or plasma samples and addition of fluperlapine as internal standard, the samples were injected into the HPLC system. On-line sample clean-up was conducted on a column (10 x 4.0 mm ID) filled with silica C8 material (20-microm particle size) using 8% (vol/vol) acetonitrile in deionized water as eluent. Ziprasidone was eluted and separated on ODS Hypersil C18 material (5 microm; column size 250 x 4.6 mm ID) using acetonitrile-water-tetramethylethylendiamine (50:49.6…

AdultMaleTime FactorsSensitivity and SpecificityHigh-performance liquid chromatographyDrug Administration SchedulePiperazinesAutomationBenzodiazepinesBlood serumColumn chromatographymedicineHumansPharmacology (medical)ZiprasidoneClozapineChromatography High Pressure LiquidPharmacologyDetection limitChromatographymedicine.diagnostic_testElutionChemistryReproducibility of ResultsMiddle AgedThiazolesOlanzapineSpectrophotometryTherapeutic drug monitoringSchizophreniaFemaleDrug MonitoringQuantitative analysis (chemistry)medicine.drugTherapeutic Drug Monitoring
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Do palatal implants remain positionally stable under orthodontic load? A clinical radiologic study.

2009

Introduction The aim of this study was to determine the positional stability and success rate of palatally placed length-reduced temporary anchorage devices (LRTADs) (length, 4 or 6 mm). Methods Twenty-two patients (ages, 21-62 years; 14 women, 8 men) were enrolled in the study. Each received 1 LRTAD (Orthosystem, Straumann, Switzerland) placed in the midsagittal palate for multifunctional anchorage tasks. Standardized cephalograms were taken directly after implant placement and at the end of treatment to analyze any implant movements. The cephalometric tracings were superimposed on anterior nasal spine to posterior nasal spine in posterior nasal spine to analyze changes in implant angulati…

AdultMaleTime FactorsTooth Movement TechniquesCephalometryBone ScrewsDentistryOrthodonticsOsseointegrationWeight-BearingYoung AdultOsseointegrationmedicineOrthodontic Anchorage ProceduresHumansOrthodontic Appliance DesignLongitudinal StudiesOrthodonticsDental Implantsbusiness.industryPalateDental Implantation EndosseousAnterior nasal spineCraniometryMiddle Agedmedicine.diseaseOrthodontic Anchorage ProceduresRadiographymedicine.anatomical_structureMaxillaFemaleImplantStress MechanicalMalocclusionPosterior nasal spinebusinessMalocclusionAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
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Transcranial Doppler diagnosis of cerebral vasospasm following subarachnoid haemorrhage: correlation and analysis of results in relation to the age o…

1994

A retrospective analysis was undertaken to determine whether cerebral vasospasm following subarachnoid haemorrhage (SAH) correlates with the age of patients. For at least 3 weeks after bleeding 80 subjects underwent very close follow-up with clinical examination and transcranial Doppler records of the blood velocities within the basal cerebral arteries. Firstly a correlation between measured maximal mean blood flow velocities and age was made. Secondly, according to their age and the maximum of recorded mean velocities (v), the patients were divided into groups as follows: age 55 years or less, age more than 55 years; and maximum velocity v190 cm/s, 90 cm/sv2120 cm/s, 120 cm/sv3160 cm/s, v4…

AdultMaleUltrasonography Doppler TranscranialCerebral arteriesAneurysm RupturedDrug Administration ScheduleCerebral vasospasmMedicineHumanscardiovascular diseasesNeuroradiologyAgedRetrospective StudiesDose-Response Relationship Drugbusiness.industryVascular diseaseAge FactorsVasospasmIntracranial AneurysmLaser Doppler velocimetryMiddle AgedSubarachnoid Hemorrhagemedicine.diseasenervous system diseasesTranscranial Dopplermedicine.anatomical_structureIschemic Attack TransientAnesthesiaCerebrovascular CirculationSurgeryFemaleNimodipineNeurology (clinical)businessBlood Flow VelocityArteryFollow-Up StudiesActa neurochirurgica
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Effects of vasopressin on human renal arteries

1996

The effects of vasopressin were studied in isolated rings from branches (2-3 mm in external diameter) of human renal arteries obtained from 18 patients undergoing nephrectomy for non-obstructive neoplasia. In arterial rings under resting tension, vasopressin produced concentration-dependent and endothelium-independent contractions with an EC 50 of 9.1 x 10 -10 mol L -1 . The vasopressin V 1 receptor antagonist d(CH 2 ) 5 Tyr(Me)AVP (10 -6 mol L -1 ) displaced the control curve to vasopressin 564-fold to the right in a parallel manner. In precontracted arterial rings and previously treated with the V 1 antagonist (10 -6 mol L -1 ) vasopressin caused endothelium-independent relaxation. The re…

AdultMaleVasopressinmedicine.medical_specialtyVasopressinsmedicine.drug_classMuscle RelaxationIndomethacinClinical BiochemistryNeuropeptideBiologyBiochemistryNorepinephrineRenal ArteryInternal medicinemedicineHumansVasoconstrictor AgentsAgedVasopressin receptorKidneyDose-Response Relationship DrugAnti-Inflammatory Agents Non-SteroidalAntagonistGeneral MedicineMiddle AgedReceptor antagonistmedicine.anatomical_structureEndocrinologyCirculatory systemFemaleEndothelium Vascularmedicine.symptomhormones hormone substitutes and hormone antagonistsVasoconstrictionMuscle ContractionEuropean Journal of Clinical Investigation
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Anger superiority effect for change detection and change blindness

2013

Abstract In visual search, an angry face in a crowd “pops out” unlike a happy or a neutral face. This “anger superiority effect” conflicts with views of visual perception holding that complex stimulus contents cannot be detected without focused top-down attention. Implicit visual processing of threatening changes was studied by recording event-related potentials (ERPs) using facial stimuli using the change blindness paradigm, in which conscious change detection is eliminated by presenting a blank screen before the changes. Already before their conscious detection, angry faces modulated relatively early emotion sensitive ERPs when appearing among happy and neutral faces, but happy faces only…

AdultMaleVisual perceptionmedia_common.quotation_subjectHappinessExperimental and Cognitive PsychologyAngerAngerStimulus (physiology)Visual processingYoung AdultArts and Humanities (miscellaneous)Face perceptionDevelopmental and Educational PsychologyHumansEvoked Potentialsta515media_commonVisual searchElectroencephalographyFacial ExpressionPattern Recognition VisualSocial PerceptionChange blindnessFemalePsychologyChange detectionCognitive psychologyConsciousness and cognition
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Time-related effects of thyrotropin-releasing hormone (TRH) on the pituitary-thyroid axis and extrathyroidal targets.

2009

Thyrotropin-releasing hormone (TRH) is a tripeptide and acts as a stimulator of the pituitary-thyroid axis as well as having a great number of well defined extrathyroidal functions. Studies in experimental animals have shown, that TRH also has a role as a neuromodulator within the autonomous nervous system. In this study we analyzed the effects following peripheral administration of TRH (200 micrograms, 400 micrograms) in patients with endocrinological disorders and in healthy females and males. By means of a questionnaire, patients were asked about possible (side-) effects; ventilatory and cardiovascular monitoring was performed during steady state. The pulsatile TSH-secretion pattern was …

AdultMaleendocrine systemmedicine.medical_specialtyTime Factorsendocrine system diseasesEndocrinology Diabetes and MetabolismThyrotropin-releasing hormoneThyrotropinStimulationEndocrine System DiseasesNorepinephrine (medication)Pituitary thyroid axisEndocrinologyHeart RateInternal medicineSurveys and QuestionnairesHeart rateInternal MedicinemedicineHumansThyrotropin-Releasing Hormonebusiness.industryRespirationThyroidGeneral Medicinemedicine.anatomical_structureEpinephrineEndocrinologyFemalebusinesshormones hormone substitutes and hormone antagonistsmedicine.drugHormoneExperimental and clinical endocrinology
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Intra- and inter-rater reliability of thoracic spine mobility and posture assessments in subjects with thoracic spine pain

2020

Abstract Background The thoracic spine (TS) has been neglected in the study of the spine despite its essential role in the stability and posture of the entire spinal complex. Therefore, there is an inevitable need to investigate the reproducibility of different thoracic spinal posture measures used in subjects with TS pain. Methods Thirty-two subjects (16 females and 16 males, mean age 39 years) were evaluated by two physiotherapists on the same day to gauge inter-rater reliability and on two consecutive days to gauge intra-rater reliability. TS posture was assessed by observation, and thoracic spine mobility was measured by manual assessment of segmental flexion and extension mobility in a…

AdultMalelcsh:Diseases of the musculoskeletal systemobservationthoracictape measureThoracicPosturePainClinical examinationObservationspinefysioterapiaclinical examinationselkärankaManual therapyHumanspainRange of Motion ArticularreliabiliteettiObserver VariationryhtiPalpationreliabilityReproducibility of ResultsinclinometerReliabilitySpineTape measuremanual therapyInclinometerliikkuvuuspalpationkrooninen kipuFemalelcsh:RC925-935arviointiResearch Article
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A double-blind study comparing paroxetine and maprotiline in depressed outpatients.

1997

A double-blind multicenter randomized parallel group study comparing paroxetine and maprotiline was carried out in a total of 544 outpatients. Included were patients with varying degrees of severity of depressive symptoms who fulfilled modified RDC criteria for either Minor or Major Depression and showed a HAMD-17 score of > or = 13. No concomitant benzodiazepine treatment was allowed. Duration of treatment was 6 weeks, after an initial wash-out period. Doses were fixed during the first 3 weeks of treatment, patients receiving either 20 mg paroxetine or 100 mg maprotiline daily. An option for dose escalation was provided for insufficient responders after 3 weeks. The weekly assessments comp…

AdultMalemedicine.drug_classDouble-Blind MethodAnticholinergicAmbulatory CareMedicineHumansPharmacology (medical)Adverse effectMaprotilinePsychiatric Status Rating ScalesBenzodiazepineDepressive Disorderbusiness.industryGeneral MedicineParoxetinePsychiatry and Mental healthParoxetineMaprotilineConcomitantAnesthesiaAntidepressantAntidepressive Agents Second-GenerationFemalebusinessReuptake inhibitormedicine.drugPharmacopsychiatry
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Urine tropenol ester levels in workers handling tiotropium bromide synthesis: implications for exposure prevention and biomonitoring

2019

Tropenol ester is a highly toxic anticholinergic substance and an intermediate used in industrial production of the bronchodilator tiotropium bromide. The aim of this study was to systematically test workers involved in its production for tropenol ester in urine to identify any exposure pathways and define additional preventive measures. Twelve workers performing tasks involving potential exposure to tropenol ester were repeatedly monitored at the end of each production cycle. Medical exams revealed no symptoms of acute poisoning with tropenol ester, but biological monitoring of urine showed 36 positive findings in 79 samples, with tropenol ester concentrations ranging between the detection…

AdultMalemedicine.drug_classProduction cycleAnticholinergic agentsUrinePharmacologyToxicologyCholinergic AntagonistsYoung Adult03 medical and health sciences0302 clinical medicineOccupational ExposureBronchodilatorBiomonitoringAnticholinergicmedicineHumans030212 general & internal medicineTiotropium Bromidebusiness.industryanaliza radnog mjesta; antikolinergici; međuproizvodi; prevencija; skopin esterPublic Health Environmental and Occupational Healthanticholinergic agents; intermediates; prevention; scopine ester; workplace analysisTiotropium bromide030210 environmental & occupational healthAcute toxicitybusinessBiological MonitoringEnvironmental Monitoringmedicine.drugArchives of Industrial Hygiene and Toxicology
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The Long-Term Effects of Physical Loading and Exercise Lifestyles on Back-Related Symptoms, Disability, and Spinal Pathology Among Men

1995

Study design Historical cohort, including selected subgroups. Objectives To understand the long-term effects of exercise on back-related outcomes, back pain, sciatica, back-related hospitalizations, pensions, and magnetic resonance imaging findings were studied among former elite athletes. Summary of background data Exercise and sports participation have become increasingly popular, as have recommendations of exercises for back problems, but little is known about their long-term effects. Methods Questionnaires were returned by 937 former elite athletes and 620 control subjects (83% response rate). Identification codes allowed record linkage to hospital discharge and pension registers. Magne…

AdultMalemedicine.medical_specialtyAdolescentCohort StudiesDisability EvaluationPensionsSciaticaLumbarPhysical medicine and rehabilitationSurveys and QuestionnairesmedicineBack painHumansOrthopedics and Sports MedicineExercise physiologyExerciseLife Stylehealth care economics and organizationsAgedSciaticabiologybusiness.industryAthletesAge FactorsOdds ratioMiddle Agedequipment and suppliesbiology.organism_classificationMagnetic Resonance ImagingSpineHospitalizationPhysical therapyNeurology (clinical)medicine.symptombusinessLow Back Painhuman activitiesRecord linkageSportsCohort studySpine
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