Search results for "pirazol"

Nuovi derivati 3,5-diaril-4,5-diidropirazolici come inibitori di HSP90

2008

ω-Hetarilbutānskābes atvasinājumu iegūšana pretvēža aktivitātes noteikšanai: pieclocekļu heterocikli ar diviem heteroatomiem

2022

Ω-hetarilbutānskābes atvasinājumu iegūšana pretvēža aktivitātes noteikšanai: pieclocekļu heterocikli ar diviem heteroatomiem. Kondibo V., zinātniskais vadītājs Dr. chem. Igors Kļimenkovs. Bakalaura darbs, 32 lappuses, 34 attēli, 23 literatūras avoti, 15 pielikumi, Latviešu valodā. Bakalaura darba ietvaros ir novērtēti 4-(5-fenil-1H-3-pirazolil)butānskābe , 4-(5-fenil-3-izoksazolil)butānskābe un 4-(4-fenil-1H-2-imidazolil)butānamīds sintēzes iespējas.

SCREENING APOPTOTICI SU NUOVI DERIVATI PIRAZOLO[1,2-A]BENZO[1,2,3,4]TETRAZINONI

2009

NUOVI COMPOSTI PIRAZOLO[3,4-H]CHINOLINICI, LORO PREPARAZIONE ED USO MEDICO

2016

La presente invenzione si riferisce al campo dei composti pirazolo[3,4-h]chinolinici, loro preparazione ed uso medico, in particolare per la cura di patologie a carattere iperproliferativo comprese quelle di natura neoplastica.

Sintesi di Nuovi Derivati del Sistema Triciclico Pirazolo[3,4-d][1,2,3]triazolo[1,5-a]pirimidinico DNA interattivi

2008

Pirazolo[3,4-h]chinoline come nuova classe di agenti fotosensibilizzanti

2013

Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives

2012

Abstract A series of isochromeno[4,3-c]pyrazole-5(1H)-one derivatives 7b–h were prepared and tested at 10 μM for their ability to displace specific [3H]flunitrazepam from bovine brain membranes. The substitution pattern of the above derivatives was shown to influence the receptor affinity. The most active compound of the series was 7e, showing a 54% inhibition of [3H]flunitrazepam binding. Compounds 7a–d,i were compared with the known isomers chromeno[4,3-c]pyrazole-4(1H)-ones 14a–d,i, showing that the isochromene/chromene isomerism influences the activity.

Synthesis and structure-activity relationship studies of new 3-methyl-5-(5-propyl-1H-1-R'-3-pyrazolyl)-1H-1-R-4-nitrosopyrazoles as antimicotic agents

2015

We have reported that some 4-nitrosopyrazoles derivatives displayed in vitro and in vivo potent antifungal activity at no cytotoxic concentration and some of these compounds were 4 times more potent than Amphotericine B and Fluconazole respectively against Cryptococcus.Neoformans and C. Krusei.We reported also that the absence of NO group or its replacement with NO2 or NH2 groups gave compounds devoid of antimycotical activity. To better understand the mechanism of action and with the aim of identifying the chemical features responsible for the action, we synthesized and tested a new class of compounds in which the 4-NO group was replaced with 4-CN group having, these last, similar steric a…

Química de coordinación de macrociclos con unidades 1H-pirazol

2016

Esta tesis doctoral se ha realizado dentro del campo de estudio de la química supramolecular y se ha basado en la síntesis de receptores macrocíclicos con unidades 1H-pirazol. Estos receptores pueden formar complejos de coordinación con cationes metálicos y complejos aniónicos con aniones inorgánicos de interés medioambiental mediante la formación de enlaces de hidrógeno intermoleculares. Los objetivos planteados para la realización de esta tesis doctoral son: - Síntesis y caracterización de macrocíclicos con unidades 1H-pirazol L1-L7. - Estudio de los receptores fluorescentes L1 y L2 con cationes de metales de transición. -Estudio de la interacción del receptor L3 con aniones de interés me…

4-cyanopirazoles derivatives as a new class of compounds with potent antifungal activity

2015

Introduction We have reported that some 4-nitrosopyrazoles derivatives displayed in vitro and in vivo potent antifungal activity at no cytotoxic concentration and some of these compounds were 4 times more potent than Amphotericine B and Fluconazole respectively against Cryptococcus Neoformans and C. Krusei. We reported also that the absence of NO group or its replacement with NO2 or NH2 groups gave compounds devoid of antimycotical activity. Aim of the work To better understand the mechanism of action and with the aim of identifying the chemical features responsible for the action, we synthesized and tested a new class of compounds in which the 4-NO group was replaced with 4-CN group having…