Search results for "pit"
showing 10 items of 9314 documents
Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein
2003
ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…
Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes.
2002
<i>Objectives:</i> In an attempt to develop virus-like particles (VLPs) as experimental vaccine against human papilloma virus (HPV)-induced tumours, the HPV16 E7 oncoprotein epitopes spanning amino acid (aa) residues 35–98 were expressed on three proteins capable of VLP formation: hepatitis B virus (HBV) surface (HBs) and core (HBc) antigens, and RNA phage fr coats (frCP). <i>Methods:</i> The profile of immunoglobulin isotypes induced in Balb/C mice after immunization with purified chimeric proteins was studied. <i>Results:</i> The HBs*-E7(35–54) protein expressing E7 residues 35–54 between residues 139 and 142 of the HBs carrier formed HBs-like particles…
”Unelmieni oppitunti” englannin kielen opettajakoulutettavien visualisoimana
2017
This study views the motivation of future teachers from quite a novel perspective: in terms of vision or envisioning. The study was carried out with student teachers of English (n=31) enrolled on a MA degree programme at a university in Finland. They were asked to envision an English class of their dreams after graduating as qualified teachers. The students produced a picture and were asked to comment on it briefly and provide some further details concerning the class. The task was carried out as part of one of the first professionally oriented courses in the students’ university studies. The pictures complemented with commentaries, or pools of multimodal data, were subjected to qualitative…
Vocational teachers' professional agency in the stream of change
2013
Verkostot, paikallisuus ja eriarvoisuus
2012
Puhtaan ruoan kansainvälinen markkinointi : suomalaisen lihan markkinointi Saksan elintarvikemarkkinoille
1999
Characteristics of being hospitalized as a child with a new diagnosis of type 1 diabetes: a phenomenological study of children’s past and present exp…
2015
Background: Our understanding of children and childhood has changed over the last few decades, which may have an impact on children’s conditions in hospitals. Children’s rights have been strengthened by the “Convention on the Rights of the Child” and ward regulations. The aim of this Norwegian study was to identify potential characteristics of children's lived experience of being hospitalized diagnosed with type 1 diabetes today and from a retrospective view in the period 1950–1980, despite the many obvious external changes. Methods: This study presents a further analysis of data from two previous phenomenological studies. The first had a retrospective perspective, and the second assumed a …
Plasticity in Photoperiodism : Drosophila montana Females Have a Life-Long Ability to Switch From Reproduction to Diapause
2022
Photoperiodic reproductive diapause is an essential part of female life cycle in several insect species living on high latitudes, where overwintering in reproductive stage involves high risks for survival and progeny production. The sensitive period (SP), during which photoperiodic cues can trigger the switch from direct development to diapause, can last from a few hours or days after emergence to the entire life span of females. Moreover, in some species, sexually mature females can enter post-reproductive diapause as a response to decreasing day length and/or temperature. We studied the duration of SP for diapause induction and the females’ ability to enter post-reproductive diapause at s…
Work-family interface and psychological well-being : a personality and longitudinal perspective
2008
Tunne-elämältään tasapainoiset henkilöt kokevat muita harvemmin, että työ vie ajan perheeltä. Henkinen väsymys työssä ja parisuhteen ongelmat ennakoivat puolestaan psyykkistä pahoinvointia. Muun muassa nämä tulokset nousivat esiin Johanna Rantasen väitöstutkimuksessa, jossa hän tutki, onko yksilön persoonallisuudella merkitystä työn ja perheen yhteensovittamisen kannalta.Rantanen havaitsi, että persoonallisuuden piirteet: tunne-elämän tasapainoisuus, sovinnollisuus, tunnollisuus, ulospäinsuuntautuneisuus ja avoimuus uusille kokemuksille, ovat hyvin pysyviä yksilön ominaisuuksia aikuisuudessa. Ne ovat myös merkittäviä työn ja perheen yhteensovittamisen tuntemusten ennakoijia tilannetekijöide…