Search results for "plenadren"

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Improved insulin sensitivity and secretion in prediabetic patients with adrenal insufficiency on dual-release hydrocortisone treatment: a 36-month re…

2018

OBJECTIVE Dual-release hydrocortisone (DR-HC) provides physiological cortisol exposure, leading to an improvement of anthropometric and metabolic parameters. The aim of the study was to evaluate the effects of DR-HC on insulin secretion and sensitivity and cardiometabolic risk, indirectly expressed by the visceral adiposity index (VAI). DESIGN AND PATIENTS Retrospective analysis of 49 patients, 13 with primary and 36 with secondary adrenal insufficiency (AI), respectively, on conventional glucocorticoid treatment at baseline and switched to DR-HC for 36 months. Overall, 24 patients had AI-pre-diabetes (impaired fasting glucose, impaired glucose tolerance and the combination), and 25 had AI-…

Blood Glucoseinsulin secretionmedicine.medical_specialtyWaistHydrocortisoneEndocrinology Diabetes and Metabolism030209 endocrinology & metabolism030204 cardiovascular system & hematologySettore MED/13 - EndocrinologiaImpaired glucose tolerancePrediabetic State03 medical and health sciences0302 clinical medicineEndocrinologyInternal medicineDiabetes mellitusGlucose IntolerancemedicineAdrenal insufficiencyHumansplenadrenPrediabetesGlucocorticoidsHydrocortisoneRetrospective Studiesbusiness.industryAdrenal insufficiency; diabetes; dual-release hydrocortisone; insulin secretion; plenadren; Endocrinology Diabetes and MetabolismFastingImpaired fasting glucosemedicine.diseaseEndocrinologydiabetedual-release hydrocortisoneInsulin ResistanceWaist CircumferencebusinessGlucocorticoidmedicine.drugAdrenal InsufficiencyClinical endocrinology
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