Search results for "points"
showing 10 items of 415 documents
Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms.
2019
Abstract Ethnopharmacological relevance Rhinella schneideri and Rhinella marina are toad venoms distributed in different parts of the world, including Brazil, Columbia and amazon. Venoms extracted from different species have many clinical applications such as antimicrobial cardiotonics and treatment of cancer. Aim of the study; In this study, we aim to investigate the effect of venoms extracted from R. schneideri and R. marina on cancer cells and verify possible mechanism of action. Material and method Cytotoxicity analyses was performed using the resazurin reduction assay, where different concentrations of venoms were tested against sensitive CCRF-CEM and P-gp overexpressing ADR/CEM5000 le…
Cell fate regulation upon DNA damage : p53 Serine 46 kinases pave the cell death road
2019
Mild and massive DNA damage are differentially integrated into the cellular signaling networks and, in consequence, provoke different cell fate decisions. After mild damage, the tumor suppressor p53 directs the cellular response to cell cycle arrest, DNA repair, and cell survival, whereas upon severe damage, p53 drives the cell death response. One posttranslational modification of p53, phosphorylation at Serine 46, selectively occurs after severe DNA damage and is envisioned as a marker of the cell death response. However, the molecular mechanism of action of the p53 Ser46 phospho-isomer, the molecular timing of this phosphorylation event, and its activating effects on apoptosis and ferropt…
Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
2020
Silymarin extracted from milk thistle consisting of flavonolignan silybin has shown chemopreventive and chemosensitizing activity against various cancers. The present review summarizes the current knowledge on the potential targets of silymarin against various cancers. Silymarin may play on the system of xenobiotics, metabolizing enzymes (phase I and phase II) to protect normal cells against various toxic molecules or to protect against deleterious effects of chemotherapeutic agents on normal cells. Furthermore, silymarin and its main bioactive compounds inhibit organic anion transporters (OAT) and ATP-binding cassettes (ABC) transporters, thus contributing to counteracting potential chemor…
On the arithmetically Cohen-Macaulay property for sets of points in multiprojective spaces
2017
We study the arithmetically Cohen-Macaulay (ACM) property for finite sets of points in multiprojective spaces, especially ( P 1 ) n (\mathbb P^1)^n . A combinatorial characterization, the ( ⋆ ) (\star ) -property, is known in P 1 × P 1 \mathbb P^1 \times \mathbb P^1 . We propose a combinatorial property, ( ⋆ s ) (\star _s) with 2 ≤ s ≤ n 2\leq s\leq n , that directly generalizes the ( ⋆ ) (\star ) -property to ( P 1 ) n (\mathbb P^1)^n for larger n n . We show that X X is ACM if and only if it satisfies the ( ⋆ n ) (\star _n) -property. The main tool for several of our results is an extension to the multiprojective setting of certain liaison methods in projective space.
Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells.
2012
Determining interacting cellular partners of drugs by chemical proteomic techniques is complex and tedious. Most approaches rely on activity-based probe profiling and compound-centric chemical proteomics. The anti-malarial artemisinin also exerts profound anti-cancer activity, but the mechanisms of action are incompletely understood. In the present investigation, we present a novel approach to identify artemisinin-interacting target proteins. Our approach overcomes usual problems in traditional fishing procedures, because the drug was attached to a surface without further chemical modification. The proteins identified effect among others, cell cycle arrest, apoptosis, inhibition of angiogen…
Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H(2)O(2) via mechanisms involving AP-1 activation.
2012
Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases such as chronic obstructive pulmonary disease (COPD). They can alter the expression of genes involved in cellular damage by activating transcription factors, including the NF-κB and the activator protein 1 (AP-1). Phosphodiesterase type 4 (PDE4) inhibitors have anti-inflammatory and antioxidant effects, as described in in vivo and in vitro COPD models. This study analysed the effects of piclamilast, a selective PDE4 inhibitor, on modulating the global gene expression profile in A549 cells exposed to H(2)O(2).Changes in gene expression were analysed using high-density Affymetrix microarrays and valid…
Common fixed points for self mappings on compact metric spaces
2013
In this paper we obtain a result of existence of points of coincidence and of common fixed points for two self mappings on compact metric spaces satisfying a contractive condition of Suzuki type. We also present some examples to illustrate our results. Moreover, using the scalarization method of Du, we deduce a result of common fixed point in compact cone metric spaces.
Multiple solutions for a Neumann-type differential inclusion problem involving the p(.)-Laplacian
2012
Using a multiple critical points theorem for locally Lipschitz continuous functionals, we establish the existence of at least three distinct solutions for a Neumann-type differential inclusion problem involving the $p(\cdot)$-Laplacian.
Multiprojective spaces and the arithmetically Cohen-Macaulay property
2019
AbstractIn this paper we study the arithmetically Cohen-Macaulay (ACM) property for sets of points in multiprojective spaces. Most of what is known is for ℙ1× ℙ1and, more recently, in (ℙ1)r. In ℙ1× ℙ1the so called inclusion property characterises the ACM property. We extend the definition in any multiprojective space and we prove that the inclusion property implies the ACM property in ℙm× ℙn. In such an ambient space it is equivalent to the so-called (⋆)-property. Moreover, we start an investigation of the ACM property in ℙ1× ℙn. We give a new construction that highlights how different the behavior of the ACM property is in this setting.
Fixed points of α-type F-contractive mappings with an application to nonlinear fractional differential equation
2016
Abstract In this paper, we introduce new concepts of α-type F-contractive mappings which are essentially weaker than the class of F-contractive mappings given in [21, 22] and different from α-GF-contractions given in [8]. Then, sufficient conditions for the existence and uniqueness of fixed point are established for these new types of contractive mappings, in the setting of complete metric space. Consequently, the obtained results encompass various generalizations of the Banach contraction principle. Moreover, some examples and an application to nonlinear fractional differential equation are given to illustrate the usability of the new theory.