Search results for "polycation"

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Improvements in Rational Design Strategies of Inulin Derivative Polycation for siRNA Delivery.

2016

The advances of short interfering RNA (siRNA)-mediated therapy provide a powerful option for the treatment of many diseases, including cancer, by silencing the expression of targeted genes involved in the progression of the pathology. On this regard, a new pH-responsive polycation derived from inulin, Inulin-g-imidazole-g-diethylenetriamine (INU-IMI-DETA), was designed and employed to produce INU-IMI-DETA/siRNA "Inulin COmplex Nanoaggregates" (ICONs). The experimental results showed that INU-IMI-DETA exhibited strong cationic characteristics and high solubility in the pH range 3-5 and self-aggregation triggered by pH increase and physiological salt concentration. INU-IMI-DETA showed as well…

polycationssiRNA deliverySmall interfering RNAPolymers and PlasticsInulinBioengineering02 engineering and technology010402 general chemistry01 natural sciencesBiomaterialschemistry.chemical_compoundDrug Delivery SystemsMaterials ChemistryPolyaminesGene silencingHumansGene SilencingRNA Small Interferingpolycations siRNA delivery inulinRational designInulinBafilomycinRNATransfectionHydrogen-Ion Concentration021001 nanoscience & nanotechnologyEndolysosomePolyelectrolytesEndocytosis0104 chemical scienceschemistryBiochemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug DesignMCF-7 Cellspolycations; siRNA delivery; inulin0210 nano-technologyBiomacromolecules

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PEPhysical Sciences and Engineering
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