Search results for "polypharmacy"

showing 10 items of 77 documents

Controlled transdermal iontophoresis for poly-pharmacotherapy: Simultaneous delivery of granisetron, metoclopramide and dexamethasone sodium phosphat…

2015

Iontophoresis has been used to deliver small molecules, peptides and proteins into and across the skin. In principle, it provides a controlled, non-invasive method for poly-pharmacotherapy since it is possible to formulate and to deliver multiple therapeutic agents simultaneously from the anodal and cathodal compartments. The objective of this proof-of-principle study was to investigate the simultaneous anodal iontophoretic delivery of granisetron (GST) and metoclopramide (MCL) and cathodal iontophoresis of dexamethasone sodium phosphate (DEX-P). In addition to validating the hypothesis, these are medications that are routinely used in combination to treat chemotherapy-induced emesis. Two p…

MaleMetoclopramideSwinePharmaceutical Science02 engineering and technologyPharmacologyGranisetronAdministration Cutaneous030226 pharmacology & pharmacyDexamethasoneGranisetron03 medical and health sciences0302 clinical medicineDexamethasone Sodium PhosphatePharmacokineticsIn vivomedicineAnimalsRats WistarDexamethasoneActive metaboliteTransdermalSkinIontophoresisChemistryHydrolysisIontophoresis021001 nanoscience & nanotechnologyRatsPolypharmacy0210 nano-technologymedicine.drugEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
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Simultaneous controlled iontophoretic delivery of pramipexole and rasagiline in vitro and in vivo: Transdermal polypharmacy to treat Parkinson's dise…

2018

[EN] Effective treatment of Parkinson's disease (PD) involves administration of therapeutic agents with complementary mechanisms of action in order to replenish, sustain or substitute endogenous dopamine. The objective of this study was to investigate anodal co-iontophoresis of pramipexole (PRAM; dopamine agonist) and rasagiline (RAS; MAO-B inhibitor) in vitro and in vivo. Passive permeation of PRAM and RAS (20 mM each) across porcine skin after 6 h was 15.7 +/- 1.9 and 16.0 +/- 2.9 mu g/cm(2), respectively. Co-iontophoresis at 0.15, 0.3 and 0.5 mA/cm(2) resulted in statistically significant increases in delivery of PRAM and RAS; at 0.5 mA/cm(2), cumulative permeation of PRAM and RAS was 61…

MaleParkinson's diseaseSwineChemistry PharmaceuticalSkin AbsorptionPharmaceutical SciencePharmacologyAdministration Cutaneous030226 pharmacology & pharmacyDopamine agonistPermeability03 medical and health scienceschemistry.chemical_compound0302 clinical medicinePramipexolePharmacokineticsIn vivomedicineAnimalsHumansBenzothiazolesMAO-B inhibitorRats WistarTransdermalSkinRasagilinePramipexoleIontophoresisDopamine agonistPatient complianceParkinson DiseaseGeneral MedicineIontophoresismedicine.diseaseRatschemistryIndansPolypharmacyElectroosmosisTransdermal030217 neurology & neurosurgeryBiotechnologymedicine.drugEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
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Prevalence of systemic diseases among patients requesting dental consultation in the public and private systems

2010

Objectives: To determine the prevalence and aetiology of systemic disease among patients requesting dental treatment in public and private practice. Study Design: A retrospective analysis was performed of the medical histories of 2000 patients requesting dental treatment during the year 2009. One thousand patients came from the Fontiñas Primary Care Oral and Dental Health Unit of the Galician Health Service (SERGAS), Spain, and the other thousand from a private clinic; both clinics were situated in Santiago de Compostela, La Coruña, Spain. The data collected were the following: demographic data (age and sex), presence or absence of systemic diseases and the nosologic categories, and drug hi…

MalePediatricsmedicine.medical_specialtyMEDLINEDiseasePrevalencemedicineHumansDiseaseDental Health ServicesGeneral DentistryRetrospective StudiesPolypharmacyPublic Sectorbusiness.industryPublic healthPublic sectorRetrospective cohort studyMiddle Aged:CIENCIAS MÉDICAS [UNESCO]OtorhinolaryngologyPrivate practiceFamily medicineUNESCO::CIENCIAS MÉDICASEtiologyFemalePrivate SectorResearch-ArticleOdontostomatology for the Disabled or Special PatientsSurgerybusinessMedicina Oral Patología Oral y Cirugia Bucal
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<p>Agreement of a Short Form of the Self-Administered Multidimensional Prognostic Index (SELFY-MPI-SF): A Useful Tool for the Self-Assessment o…

2020

Alberto Cella,1 Alberto Ferrari,2 Giuseppe Rengo,3 Vincenzo Solfrizzi,4 Nicola Veronese,5 Matteo Puntoni,6 Sabrina Zora,1 Alberto Pilotto,1,4 Filippo Fimognari7 On behalf of the SELFY-MPI SIGOT Investigators1Geriatric Unit, Department of Geriatric Care, Orthogeriatrics and Rehabilitation, EO Galliera Hospital, Genova, Italy; 2Geriatric Unit, Arcispedale S. Maria Nuova, AUSL Reggio Emilia, Reggio Emilia, Italy; 3Department of Translational Medical Sciences, Division of Geriatrics, Federico II University, Napoli, Italy; 4Department of Interdisciplinary Medicine, University of Bari, Bari, Italy; 5Primary Care Department, Azienda ULSS 3 Serenissima, Venice, Italy; 6Scientific Coordination Unit,…

MaleSelf-assessmentGerontologySelf-AssessmentIndex (economics)Activities of daily livingInterpersonal RelationReproducibility of ResultNutritional StatusSample (statistics)Comorbidity03 medical and health sciencesCognition0302 clinical medicineRisk Factorsself assessmentActivities of Daily LivingHumansMedicineInterpersonal Relations030212 general & internal medicineGeriatric AssessmentAgedOriginal ResearchAged 80 and overFrailtybusiness.industryRisk FactorSelfReproducibility of ResultsCognitionGeneral MedicineMiddle AgedPhysical Functional Performancecomprehensive geriatric assessmentmedicine.diseaseComorbiditymultidimensional prognostic indexNutritional StatuClinical Interventions in AgingPolypharmacyFemaleIndependent LivingGeriatrics and GerontologybusinessOlder peoplecomprehensive geriatric assessment multidimensional prognostic index frailty self assessmen030217 neurology & neurosurgeryHumanClinical Interventions in Aging
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Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study

2011

PURPOSES: We evaluated the prevalence and factors associated with polypharmacy and investigated the role of polypharmacy as a predictor of length of hospital stay and in-hospital mortality. METHODS: Thirty-eight internal medicine wards in Italy participated in the Registro Politerapie SIMI (REPOSI) study during 2008. One thousand three hundred and thirty-two in-patients aged ≥65 years were enrolled. Polypharmacy was defined as the concomitant use of five or more medications. Linear regression analyses were used to evaluate predictors of length of hospital stay and logistic regression models for predictors of in-hospital mortality. Age, sex, Charlson comorbidity index, polypharmacy, and numb…

MaleSettore MED/09 - Medicina InternaMultivariate analysis030204 cardiovascular system & hematologyLogistic regressionCohort Studies0302 clinical medicineElderlyPrevalenceMedicinePharmacology (medical)Hospital MortalityProspective Studies030212 general & internal medicinePractice Patterns Physicians'Prospective cohort studyComputingMilieux_MISCELLANEOUSAged 80 and overHospital stayGeneral MedicineSettore MED/45 - Scienze Infermieristiche Generali Cliniche E Pediatriche3. Good healthHospitalizationIn-hospital mortalityItalyFemalelength of hospital stayCohort studymedicine.medical_specialtyDrug PrescriptionsElderly Hospital stay In-hospital mortality PolypharmacyElderly Polypharmacy Hospital stay In-hospital mortality03 medical and health sciencesInternal medicineInternal MedicineHumansAdverse effectAgedPharmacologyPolypharmacybusiness.industryOdds ratioConfidence intervalLogistic ModelsLinear ModelsSettore BIO/14 - FarmacologiaPolypharmacybusinesselderly; hospital stay; in-hospital mortality; length of hospital stay; polypharmacy
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Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016

2019

Objective This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods Data were collected during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, only patients enrolled in acute hospital wards were selected (n = 4,133). Delirium was assessed according to score on the 4 "A's" Test. Prescriptions were classified by main drug categories; polypharmacy w…

Malediagnosismedications0302 clinical medicinepreventionAged 80 and over; Delirium; Drug Prescriptions; Female; Hospital Departments; Humans; Male; Prevalence; Polypharmacy; Prescription Drugs80 and overPrevalenceMedicineLS4_4030212 general & internal medicineAcute hospitalmedia_commonAged 80 and overConfoundingelderly patients hip fracture hospitalized patients prediction rule risk factor dementia events medications prevention diagnosisrisk-factorrisk factorhip fracturePsychiatry and Mental HealthFemalemedicine.symptomeventsDrugmedicine.medical_specialtyPrescription Drugshospitalized-patientsmedia_common.quotation_subjectMEDLINEHospital DepartmentsSocio-culturaleelderly-patientselderly patientsbehavioral disciplines and activitiesDrug Prescriptions03 medical and health sciencesInternal medicinemental disordersDementiaHumansMedical prescriptionprediction ruleAgedPolypharmacybusiness.industryhospitalized patientsDeliriummedicine.diseasenervous system diseasesPolypharmacyDeliriumelderly-patients; hip fracture; hospitalized-patients; prediction rule; risk-factor; dementia; events; medications; prevention; diagnosisbusiness030217 neurology & neurosurgerydementia
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Hospital Care of Older Patients With COPD: Adherence to International Guidelines for Use of Inhaled Bronchodilators and Corticosteroids

2019

Abstract Objectives We aimed to analyze the prevalence and impact of COPD in older patients hospitalized in internal medicine or geriatric wards, and to investigate adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, associated clinical factors, and outcomes. Design Data were obtained from REgistro POliterapie SIMI (REPOSI), a prospective multicenter observational registry that enrolls inpatients aged ≥65 years. Setting and Participants Older hospitalized patients enrolled from 2008 to 2016 with a diagnosis of COPD. Measures We evaluated adherence to the 2018 GOLD guidelines at admission and discharge, by examining the prescription of inhaled bronchodi…

Malemajor clinical eventmajor clinical eventsPulmonary Disease Chronic Obstructive0302 clinical medicineOlder patientsAdrenal Cortex Hormones80 and over030212 general & internal medicineLS4_4adherenceProspective StudiesGeneral NursingNursing (all)2901 Nursing (miscellaneous)Aged 80 and overCOPDHealth PolicyGeneral MedicineCOPD guidelines adherence major clinical events older patientsolder patientsObstructive lung diseaseBronchodilator Agentsguidelines adherenceHospitalizationInhalationCOPD; guidelines adherence; major clinical events; older patients; Administration Inhalation; Adrenal Cortex Hormones; Aged; Aged 80 and over; Bronchodilator Agents; Female; Humans; Male; Prospective Studies; Pulmonary Disease Chronic Obstructive; Guideline Adherence; HospitalizationAdministrationFemaleGuideline AdherenceCOPD guidelinesCOPD; guidelines adherence; major clinical events; older patients; Nursing (all)2901 Nursing (miscellaneous); Health Policy; Geriatrics and GerontologyChronic Obstructivemedicine.medical_specialtySocio-culturalePulmonary Disease03 medical and health sciencesolder patientInternal medicineAdministration InhalationmedicineHumansCOPDMedical prescriptionAgedPolypharmacybusiness.industrySettore MED/09 - MEDICINA INTERNAOdds ratiomedicine.diseaseConfidence intervalrespiratory tract diseasesCOPD; guidelines adherence; major clinical events; older patientsObservational studyGeriatrics and Gerontologybusiness030217 neurology & neurosurgery
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Analgesic use among community-dwelling people aged 75 years and older : a population-based interview study

2010

Abstract Background: Pain is often underrecognized and undertreated among older people. However, older people may be particularly susceptible to adverse drug reactions linked to prescription and nonprescription analgesics. Objectives: The aims of this study were to assess the prevalence of analgesic use among a random sample of community-dwelling people aged ≥75 years, and to investigate factors associated with daily and as-needed analgesic use. Methods: A random sample of people aged ≥75 years was drawn from the population register in Kuopio, Finland, in November 2003. Data on prescription and nonprescription analgesic use were elicited during nurse interviews conducted once for each parti…

Malemedicine.medical_specialtyActivities of daily livingCross-sectional studyHealth StatusAnalgesicPaincross-sectional studieselderlySex FactorsResidence CharacteristicsActivities of Daily LivingHumansMedicinePharmacology (medical)painMedical prescriptionFinlandAgedAged 80 and overPolypharmacyAnalgesicsDepressionbusiness.industryData CollectionMedical recordOdds ratioAnalgesics OpioidagedCross-Sectional StudiesMultivariate AnalysisPolypharmacyPhysical therapyanalgesicsFemaleGeriatric Depression ScaleGeriatrics and Gerontologybusinessdrug utilization
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A one-year proprioceptive exercise programme reduces the incidence of falls in community-dwelling elderly people: A before-after non-randomised inter…

2016

Abstract Background The risk of falls increases with age. Balance alteration and polypharmacy are independent contributors to an increased risk of falls. Objective The primary aim was to assess whether a proprioceptive exercise programme reduces the incidence of falls. A secondary aim was to assess the association between drugs and falls. Design This was a before–after non-randomised intervention study. Participants The study recruited independent and cognitively intact community-dwelling people aged over 69 years, from December 2012 to May 2014. Methods The intervention was done by a nurse and consisted of a monthly supervised group session of proprioceptive training for 1 year, supplement…

Malemedicine.medical_specialtyActivities of daily livingPoison control030204 cardiovascular system & hematologyLower riskGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationQuality of lifeActivities of Daily LivingmedicineHumans030212 general & internal medicinePostural BalanceBalance (ability)AgedPolypharmacyAged 80 and overbusiness.industryTinetti testIncidence (epidemiology)IncidenceObstetrics and GynecologyProprioceptionExercise TherapyTreatment OutcomePhysical therapyQuality of LifeAccidental FallsFemalebusinessMaturitas
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Polypharmacy in elderly patients with type 2 diabetes receiving oral antidiabetic treatment

2016

Aim: Polypharmacy in older diabetics can have detrimental effects linked to poor adherence and the risk of drug interaction or more serious/frequent side effects. The aim of this study was to identify the characteristics associated with polypharmacy in a cohort of elderly diabetic patients being treated with oral hypoglycemic agents. Methods: The study population consisted of 1342 diabetic patients consecutively enrolled in 57 diabetes centers in Italy participating in the METABOLIC Study. Patients meeting the following inclusion criteria were enrolled: diagnosis of type 2 diabetes mellitus, age ≥65 years, and receiving oral antidiabetic treatment. Data concerning diabetes duration and comp…

Malemedicine.medical_specialtyEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismType 2 diabetesDiabetes Complications03 medical and health sciencesSex Factors0302 clinical medicineEndocrinologySurveys and QuestionnairesInternal medicineDiabetes mellitusType 2 diabetes mellitusmedicineOlder patientsInternal MedicineHumansHypoglycemic Agents030212 general & internal medicineMETABOLIC Study; Older patients; Polypharmacy; Type 2 diabetes mellitus; Endocrinology; Internal Medicine; Endocrinology Diabetes and MetabolismAgedAged 80 and overPolypharmacybusiness.industryAge FactorsType 2 Diabetes MellitusGeneral MedicinePrognosismedicine.diseaseMETABOLIC StudyDiabetes and MetabolismMalnutritionCross-Sectional StudiesEndocrinologyDiabetes Mellitus Type 2ItalyHealth Care SurveysCohortPolypharmacyPopulation studyFemalebusinessType 2 diabetes mellitus Older patients Polypharmacy METABOLIC StudyBody mass index
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