Search results for "population-based"
showing 10 items of 85 documents
An Algorithm for Discretization of Real Value Attributes Based on Interval Similarity
2013
Discretization algorithm for real value attributes is of very important uses in many areas such as intelligence and machine learning. The algorithms related to Chi2 algorithm (includes modified Chi2 algorithm and extended Chi2 algorithm) are famous discretization algorithm exploiting the technique of probability and statistics. In this paper the algorithms are analyzed, and their drawback is pointed. Based on the analysis a new modified algorithm based on interval similarity is proposed. The new algorithm defines an interval similarity function which is regarded as a new merging standard in the process of discretization. At the same time, two important parameters (condition parameterαand ti…
CN2-R: Faster CN2 with randomly generated complexes
2011
Among the rule induction algorithms, the classic CN2 is still one of the most popular ones; a great amount of enhancements and improvements to it is to witness this. Despite the growing computing capacities since the algorithm was proposed, one of the main issues is resource demand. The proposed modification, CN2-R, substitutes the star concept of the original algorithm with a technique of randomly generated complexes in order to substantially improve on running times without significant loss in accuracy.
Retinal vascular network: description in elderly and pathological process
2020
For more than 10 years, description of the retinal microvascular network has benefited from the development of new imaging techniques. Automatic retinal images analysis software, as well as OCT angiography, are able to highlight subtle and early changes in the retinal vascular network. In addition, these software allow to obtain a large amount of quantitative microvascular parameters which improve the characterization of retinal vascularization. The challenge of current research is to demonstrate the association between these microvascular modifications, systemic vascular aging process and cerebral and cardiovascular disease. Indeed, a physiopathological continuum exists between retinal mic…
Facteurs épidémiologiques influençant la survie dans le lymphome à cellules du manteau
2017
Mantle Cell Lymphoma (MCL) is a recently defined entity, typically characterised by the genetic translocation t(11 ;14)(q13 ;q32) and counting for 2 - 10% of all non-Hodgkin Lymphomas. With a median survival between 3 and 5 years after diagnosis, MCL is an agressive disease and despite the recent therapeutic advances little in know about its prognostic factors. Some studies had investigated clinicopathological features and new treatment strategies, but there is a lack of knowledge regarding the impact of lifestyle and environnemental factors on outcome of MCL patients. From 2008 to 2012, the LYSA Group conducted in France two prospective multi center clinical trials on MCL : LM manteau 2010…
Longitudinal physical activity trajectories from childhood to adulthood and their determinants : The Young Finns Study
2018
Determining lifelong physical activity (PA) trajectories and their determinants is essential to promote a physically active lifestyle throughout the life-course. We aimed to identify PA trajectories from childhood to midlife and their determinants in a longitudinal population-based cohort. This study is a part of the Cardiovascular Risk in Young Finns Study. From 1980, a population-based cohort (N = 3596; 1764 boys/1832 girls, age 3-18 years) has been followed up for 31 years. PA indices were formed based on self-reported data (between age 9-49 years) on frequency, duration, and intensity of leisure (during childhood) or high-intensity (at later age) PA and on sports club participation/comp…
A hybrid genetic algorithm with local search
2001
Abstract A hybrid genetic algorithm with internal local search was developed for optimisations involving continuous variables. The reproduction probabilities were enhanced using the fitness values obtained when a local method was applied to each individual in the population. These estimations are more realistic, since consider not the apparent but the hidden, latent quality of each individual. The information gathered in the local search was also used to build an auxiliary population recording the successfully enhanced individuals, which allowed to detect the convergence and self-adapt the search limits. The size of this auxiliary population was kept constant by a cluster analysis strategy.…
Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data
2021
Breast cancer stage at diagnosis, patient age and molecular tumor subtype influence disease progression. The aim of this study was to analyze the relationships between these factors and survival in breast cancer patients among the Italian population using data from the AIRTUM national database. We enrolled women with primary breast cancer from 17 population-based cancer registries. Patients were subdivided into older (>69 years), middle (50–69 years) and younger age groups (<50 years) and their primary tumors categorized into four molecular subtypes based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. There were 8831 patients diagnosed betwe…
Adolescent and Young Adult Cancer Survivors: Design and Characteristics of the First Nationwide Population-Based Cohort in Italy
2020
Purpose: Adolescent and young adult (AYA, 15-39 years) cancer survivors (alive at least 5 years after cancer diagnosis) are less studied than younger and older cancer survivors and research on their late effects is limited. To facilitate research on long-term outcomes of AYA cancer survivors, we established, in Italy, a population-based AYA cancer survivors' cohort. This article describes the study design and main characteristics of this cohort. Methods: The cohort derives from population-based cancer registries (CRs). Each CR identified AYA cancer patients retrospectively. Treatment for first primary cancer and all health events from diagnosis to death can be traced through linkage with av…
Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Populatio…
2016
Journal Article; OBJECTIVE To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain. METHODS Cases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for the period 1983-2007 and trends were evaluated using Joinpoint regression analysis. RESULTS The studied tumour groups accounted for 36% of total childhood cancers and 47.6% of those diagnosed in adolescence with annual rates per million of 53.5 and 89.3 respectively. In children 0 to 14 years of age, Neuroblastoma (NB) was the commonest (7.8%) followed by Soft-tissue sarcomas (STS) (…
Cigarette Smoking Is Related to Endothelial Dysfunction of Resistance, but Not Conduit Arteries in the General Population—Results From the Gutenberg …
2021
Aims: Cigarette smoking is one of the most complex and least understood cardiovascular risk factors. Importantly, differences in the tobacco-related pathophysiology of endothelial dysfunction, an early event in atherogenesis, between circulatory beds remain elusive. Therefore, this study evaluated how smoking impacts endothelial function of conduit and resistance arteries in a large population-based cohort.Methods and results: 15,010 participants (aged 35–74 years) of the Gutenberg Health Study were examined at baseline from 2007 to 2012. Smoking status, pack-years of smoking, and years since quitting smoking were assessed by a computer-assisted interview. Endothelial function of conduit an…