Search results for "porat"
showing 10 items of 1595 documents
Selective downregulation of the MDR1 gene product in Caco-2 cells by stable transfection to prove its relevance in secretory drug transport.
2005
Considerable interest is focused on overcoming multidrug resistance (MDR) in cancer chemotherapy. The in vitro experiments to characterize P-glycoprotein's (P-gp) function and to decrease its effects have led to a variety of strategies such as addition of competitors or supplementation of the medium with oligonucleotides complementary to the 5'-end of the MDR1-mRNA. For the Caco-2 cell line, an in vitro model for absorption screening, expressing multiple transporters including P-gp, which pumps substances back into the apical solution, P-gp activity might mask other relevant transport proteins' activity. The objective of the present study was to construct a Caco-2 subline with reduced P-gp …
Fabrication and characterization of vacuum deposited fluorescein thin films
2011
Simple vacuum evaporation technique for deposition of dyes on various solid surfaces has been developed. The method is compatible with conventional solvent-free nanofabrication processing enabling fabrication of nanoscale optoelectronic devices. Thin films of fluorescein were deposited on glass, fluorine-tin-oxide (FTO) coated glass with and without atomically layer deposited (ALD) nanocrystalline 20 nm thick anatase TiO2 coating. Surface topology, absorption and emission spectra of the films depends on their thickness and the material of supporting substrate. On a smooth glass surface the dye initially formes islands before merging into a uniform layer after 5 to 10 monolayers. On FTO cove…
Shareholder Wealth Creation in Response to Announcements of Acquisitions of Unlisted Firms: Evidence from Spain
2011
We investigate shareholder value creation of Spanish listed firms in response to announcements of acquisitions of unlisted companies and compare this experience to the purchase of listed firms over the period 1991–2006. Similar to foreign markets, acquirers of listed targets earn insignificant average abnormal returns, whereas acquirers of unlisted targets gain significant positive average abnormal returns. When we relate these results to company and transaction characteristics our findings diverge from those reported in the literature for other foreign markets, as our evidence suggests that the listing status effect is mainly associated with the fact that unlisted firms tend to be smaller …
Novel solutions for closed-loop Reverse Electrodialysis: thermodynamic characterisation and perspective analysis
2019
Abstract Closed-loop Reverse Electrodialysis is a novel technology to directly convert low-grade heat into electricity. It consists of a reverse electrodialysis (RED) unit where electricity is produced exploiting the salinity gradient between two salt-water solutions, coupled with a regeneration unit where waste-heat is used to treat the solutions exiting from the RED unit and restore their initial composition. One of the most important advantages of closed-loop systems compared to the open systems is the possibility to select ad-hoc salt solutions to achieve high efficiencies. Therefore, the properties of the salt solutions are essential to assess the performance of the energy generation a…
Daily evapotranspiration assessment by means of residual surface energy balance modeling: A critical analysis under a wide range of water availability
2012
Summary An operational use of the actual evapotranspiration assessed by remote sensing approaches requires the integration of instantaneous fluxes to daily values. This is commonly achieved under the hypotheses of daytime self-preservation of evaporative fraction and negligible daily ground heat flux. The aim of this study is to evaluate the effect of these assumptions on estimate daily evapotranspiration over a full phenological cycle, including phases characterized by significant changes both in net radiation and vegetation cover. To assess the reliability of these hypotheses, the observations made by a flux tower, installed within a homogeneous field of cereal located in the valley part …
Effects of rainfall events on the evapotranspiration retrieved by an energy balance model
2009
An alternative way to map the actual evapotranspiration (ET) spatial distribution at daily scale is the application of residual surface energy balance models to satellite images that are characterised by high temporal frequency and moderate spatial resolution, like those acquired by the MODIS sensors on board of TERRA and AQUA platforms. Within this research the well-known SEBAL model has been applied on an area located in the southern part of Sicily (Imera Meridionale catchment) using four images acquired between the 27th of March and the 11th of April 2007. The catchment extends for about 2000 km2 and includes both mountains and hill areas: the first are located in the northern part (the …
Transpiration and Water Use of an Irrigated Traditional Olive Grove with Sap-Flow Observations and the FAO56 Dual Crop Coefficient Approach
2021
The SIMDualKc model was applied to evaluate the crop water use and the crop coefficient (Kc) of an irrigated olive grove (Olea europaea L.) located in Sicily, Italy, using experimental data collected from two crop seasons. The model applies the FAO56 dual Kc approach to compute the actual crop evapotranspiration (ETc act) and its components, i.e., the actual tree transpiration (Tc act), obtained through the basal crop coefficient (Kcb), and soil evaporation according to an evaporation coefficient (Ke). Model calibration was performed by minimizing the difference between the predicted Tc act and the observed daily tree transpiration measured with sap flow instrumentation (TSF field) acquired…
Quality-of-Life Priorities in Patients with Thyroid Cancer : a Multinational European Organisation for Research and Treatment of Cancer Phase I Study
2016
Item does not contain fulltext BACKGROUND: The objectives of this study were to determine quality of life (QoL) issues that are relevant to thyroid cancer patients cross-culturally, and to identify those with highest relevance to them in addition to the more general issues covered by the core European Organisation for Research and Treatment of Cancer QoL questionnaire (EORTC QLQ-C30). METHODS: A systematic literature search provided a list of potentially relevant QoL issues to supplement the core questionnaire EORTC QLQ-C30, which is widely used in research and in care and addresses QoL issues relevant to all groups of cancer patients. A panel of experts revised this list, and thyroid cance…
Further examination of the organizational culture scale of artifacts
2009
The construct validity of a 10-item Organizational Culture Scale Focused on Artifacts oriented to measure traditional culture was analyzed under the unidimensionality hypothesis of the scale. Confirmatory factor analysis was conducted to assess the unidimensional structure, which took into account the method effects associated with reverse-worded items. The results based on the data from a sample of 926 subjects, 79.8% male, mean age of 33.4 years (SD = 12.8), working in different types of companies suggested the proposed unidimensional factor structure, with the elimination of two items from the scale. The resulting 8-item scale was reanalyzed, this time with the data of a second split-sam…
Unveiling the Antecedents of International Diversification: An Agency Theory Approach
2014
While various studies have developed hypotheses about the antecedents of international diversification drawing mainly on the resource-based view, the behavioral theory of the firm, and the transaction costs literature, we advance our understanding by investigating the explanatory power of agency costs of free cash flow arguments. Using a sample panel of 167 Italian firms longitudinally evaluated during the 1980-2010 period, this study tests whether the firm’s choice to spread operations in multiple foreign countries is conditioned by excess of free cash flow and debt, especially in firm-contexts where agency problems are exacerbated by managers or large shareholders’ opportunism. We find th…