Search results for "porphine"
showing 4 items of 24 documents
(Bu3Sn)4TPPS and (Bu2Sn)2TPPS significantly inhibit the growth, migrationand tumorigenicity of human malignant melanoma cells
2018
Melanoma is one of the most aggressive and treatment-resistant human cancers, it is responsible worldwide for the 80% of skin cancer related deaths which is largely due to its propensity to metastasize to other organs. The growing understanding of the pathways involved in melanoma progression and development has led to the identification of some interesting new molecules, however, the treatment options for metastatic melanoma remain limited. Indeed, the key step in metastasis development is the tumour cell invasion of the nearby host tissue and the journey powerfully depends on the detachment of single tumour cells from the primary tumour. Therefore, the ability to block the migratory and i…
3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor.
2013
Abstract Dopamine-mediated neurotransmission plays an important role in relevant psychiatric and neurological disorders. Nowadays, there is an enormous interest in the development of new drugs acting at the dopamine receptors (DR) as potential new targets for the treatment of schizophrenia or Parkinson’s disease. Previous studies have revealed that isoquinoline compounds such as tetrahydroisoquinolines (THIQs) can behave as selective D 2 dopaminergic alkaloids. In the present study we have synthesized five aporphine compounds and five phenanthrene alkaloids and evaluated their potential dopaminergic activity. Binding studies on rat striatal membranes were used to evaluate their affinity and…
Electrocatalytic properties of manganese and cobalt polyporphine films toward oxygen reduction reaction
2018
International audience; Novel member of polymetalloporphines, namely manganese polymetalloporphine of type I (pMnP-I) obtained by ion exchange from magnesium polyporphine of type I (pMgP-I) is reported for the first time and compared to its cobalt analogue (pCoP-I). Both polymer films have been obtained via two-step procedure: demetaladon of the pMgP-I electrode film via its exposure to trifluoroacetic acid solution, resulting in formation of the metal-free polyporphine of type I (pH(2)P-I) followed by electrochemically induced incorporation of Co or Mn ions from the acetonitrile solution of cobalt and manganese perchlorates. A further oxidative transformation of pCoP-I, polymer films has l…
Different mechanism of relaxation induced by aporphine alkaloids in rat uterus.
1993
Abstract We have examined the uterine relaxant action of three aporphine molecules (S-glaucine, S-boldine and R-apomorphine) in two experimental conditions, with and without calcium in the bathing solution, and compared these effects with those obtained with the calcium antagonists verapamil and diltiazem. The present study shows that the alkaloids relax the uterine muscle but with different mechanisms of action. In Ca2+-containing solution all three alkaloids relaxed the uterus previously contracted by KCl or acetylcholine, but in Ca2+-free medium only R-apomorphine was able to relax oxytocin-induced contraction. The calcium antagonists, verapamil and diltiazem, relaxed KCl- or acetylcholi…