Search results for "porte"
showing 10 items of 1894 documents
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract
Inhibition of ATP-Binding Cassette Transporters by Chinese Herbs and Phytochemicals
2012
The gene family of ATP-binding cassette (ABC) transporters is widely distributed over the evolutionary tree of life from bacteria to man. In cancer, several ABC transporters are involved in the transport of anticancer drugs. This leads to the development of resistance to a broad spectrum of anticancer agents, termed multidrug resistance. An attractive strategy to overcome multidrug resistance is to block the transport function of ABC transporters leading to lethal intracellular concentrations of anticancer drugs. Efforts to identify transport inhibitors lead to a huge amount of chemical substances, none of which successfully passed clinical trials in cancer patients because of high toxicity…
Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells
2019
Abstract Background Cucurbitacin E (CuE) is an oxygenated tetracyclic triterpenoid isolated from the fruits of Citrullus colocynthis (L.) Schrad. Purpose This study outlines CuE's cytotoxic activity against drug-resistant tumor cell lines. Three members of ABC transporters superfamily, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and ABCB5 were investigated, whose overexpression in tumors is tightly linked to multidrug resistance. Further factors of drug resistance studied were the tumor suppressor TP53 and the epidermal growth factor receptor (EGFR). Methods Cytotoxicity assays (resazurin assays) were used to investigate the activity of Citrullus colocynthis and CuE towar…
Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix.
2012
Purpose: This study investigated the absorption mechanism of the phytochemicals indicaxanthin and betanin and the influence of their food matrix (cactus pear and red beet) on the intestinal transport. Methods: Trans-epithelial transport of dietary-consistent amounts of indicaxanthin and betanin in Caco-2 cell monolayers seeded on TranswellR inserts was measured in apical to basolateral (AP-BL) and basolateral to apical (BL-AP) direction, under an inwardly directed pH gradient (pH 6.0/7.4, AP/BL) mimicking luminal and serosal sides of human intestinal epithelium. The effect of inhibitors of membrane transporters on the absorption was also evaluated. Contribution of the paracellular route was…
Les petites histoires extraordinaires des courses ordinaires: vous ne retournerez plus faire vos courses de la même façon après la lecture de cet ouv…
2011
National audience; ...
Carbons from second generation biomass as sustainable supports for catalytic systems
2018
In this study activated carbons were produced from the wood of three different wood species (pine, birch, spruce). The resulting activated carbons were characterized in bulk for ash content, carbon content (elemental analyses), specific surface area, and pore size distribution, and at the surface by measuring the autogenerated pH and studying their structure by XPS. All the samples presented high surface areas and appeared to be mesoporous materials (mesopores >80%). The carbons were then used as support for AuPt nanoparticles and tested in the liquid phase oxidation of glycerol (GLY) and in the hydrogenation of levulinic acid (LA), two important chemicals from cellulose-based biomass. The …
Actividad Física y deporte en la terapia de drogodependientes: Un resumen de la situación y de las posibilidades en España y Alemania
2003
Aunque la actividad físico-deportiva está siendo establecida progresivamente en la rehabilitación de muchas enfermedades y en la mejora de la salud, su grado de recono¬cimiento en el área de la drogodependencia es bajo. En este estudio se expondrá cómo la utilización del ejercicio físico y el deporte en las Comunidades Terapéuticas está insuficientemente valorada.Como un fundamento teórico de la intervención consideramos el Modelo de Salutogenesis de Antonovsky. En este contexto presentaremos investigaciones que versan sobre los beneficios del deporte y los objetivos del mismo. Revisamos la bibliografía internacio¬nal, especialmente en España y en Alemania. Además se presentarán los datos d…
Athletic identity in Spanish adolescents: psychometric properties of the Spanish version of the Athletic Identity Measurement Scale-E
2016
Este estudio pretende determinar las propiedades psicométricas de la Athletic Identity Measurement Scale en su versión traducida al español y la identidad deportiva (ID) de una muestra de adolescentes españoles. El cuestionario se administró a 441 adolescentes de 12-18 años, clasificados en: adolescentes del Programa de Especialización Deportiva (PED), adolescentes no-PED activos y adolescentes no-PED inactivos. El análisis factorial confirmatorio reveló una estructura jerárquica y multidimensional de tres factores de primer orden (identidad social, exclusividad y afectividad negativa) y uno de segundo orden, la ID. Los resultados apoyan la adecuación de los ítems en sus respectivas subesca…
Genetic proof for the transient nature of the Th17 phenotype
2010
IL-17-producing CD4(+) T cells (Th17) have been classified as a new T helper cell subset. Using an IL-17 fate mapping mouse strain, which genetically fixes the memory of IL-17 expression, we demonstrate that IL-17A/F-expressing T helper cells generated either in vitro or in vivo are not a stable T-cell subset. Upon adoptive transfer of IL-17F-reporter-positive Th17 cells to RAG-deficient or WT animals, encephalitogenic Th17 cells partially lose IL-17 expression and upregulate IFN-γ. Additionally, we show that Th1 cells can convert in vivo to IL-17A/IFN-γ-coexpressing cells in the mesenteric lymph nodes (mLN). Our data classify IL-17A and IL-17F as cytokines produced transiently in response …
A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people
2009
The T cell branch of the immune system has been extensively studied in the elderly and it is known that the elderly have impaired immune function, mainly due to the chronic antigenic load that ultimately causes shrinkage of the T cell repertoire and filling of the immunologic space with memory T cells. In the present paper, we describe the IgD(-)CD27(-) double-negative B cell population which (as we have recently described) is higher in the elderly. Most of these cells were IgG(+). Evaluation of the telomere length and expression of the ABCB1 transporter and anti-apoptotic molecule, Bcl2, shows that they have the markers of memory B cells. We also show that these cells do not act as antigen…