Search results for "porter"
showing 10 items of 920 documents
Handbol: El llançament a portería, el blocatge i les accions del porter. La col.laboració defensa porter.
2019
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València Handbol: El llançament a portería, el blocatge i les accions del porter. La col.laboració defensa porter.
Role of hypoxia in pemetrexed-resistance of mesothelioma mediated by proton-coupled folate transporter, and preclinical activity of new anti-LDH comp…
2018
Introduction There are few effective therapies for malignant pleural mesothelioma (MPM), which remains one of the most lethal cancers. We previously demonstrated that low expression of the PCFT transporter, both at mRNA and protein levels, is associated with shorter survival of MPM patients treated with pemetrexed (Giovannetti et al., 2017). Since hypoxia has also been associated to antifolate-resistance (Raz et al, 2014), this study was aimed at elucidating key factors in pemetrexed resistance and hypoxia that may contribute to the rational development of novel therapeutic interventions against mesothelioma. Methods The levels of PCFT and of the hypoxia marker carbonic anhydrase-IX were de…
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…
SIA "Exquisito" resorāna“Bangert's” konkurētspēja un attīstības iespējas Kuldīgā.
2019
Kvalifikācijas darba tēma: SIA "Exquisito" restorāna “Bangert’s” konkurētspēja un attīstības iespējas Kuldīgā. Kvalifikācijas darba mērķis: sniegt secinājumus un priekšlikums par SIA "Exquisito" restorāna “Bangert’s” konkurētspēju un attīstības iespējām Kuldīgas pilsētā. Lai sasniegtu izvirzīto mērķi, kvalifikācijas darbā tika izvirzīti konkrēti darba uzdevumi, kas risināti 3 daļās: 1.daļā autore aprakstīja teorētiski konkurenci, konkurētspēju un tās izvērtēšanas iespēju. Lai to veiktu, daļā ir 3 apakšnodaļas. 2.daļā autore raksturoja uzņēmējdarbības vidi Kuldīgas pilsētā. 3.daļā autore izstrādāja pētījumu par SIA "Exquisito" restorānu “Bangert’s”, aprakstot restorānu un veicot aptauju, kā …
Gitelman syndrome DD thiazide diuretics abuse
2014
Abstract Introduction. Gitelman syndrome (GS) is a rare inherited disorder. Mutations in SLC12A3 gene that encode tubular Na+Cl-cotransporter (NCCT) cause hypokalemic metabolic alkalosis, salt loss, hypomagnesaemia and hypocalciuria. The symptoms include weakness, vertigo, hypotension, tetany, paresthesia and nausea. Diagnostic criteria are a normal urine concentrating ability, normal glomerular filtration rate (GFR), hypomagnesaemia (<0,65mmol/l), hypokalemia (<3,6mmol/l) and hypocalciuria (<0,1mmol/mmol creatinine). Previously, the diagnosis was made by exclusion. Today, genetic analysis can ensure diagnosis. Thiazide diuretics (TD) abuse with similar abnormalities can make the d…
DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX
2022
The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the regulation of pre-mRNA splicing process. This research project is the result of a joint PhD between the University of Palermo, Italy, and the Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. It integrates complementary skills in pharmaceutical chemistry and translational cancer research with a special focus on the rational design of new anticancer compounds potentially active on SF3B1 (Splicing Factor 3B …
From “Strategic Fit” to Synergy Evaluation in M&A Deals
2012
The aim of this paper is to grasp the processes underlying the genesis and assessment of synergies in M&A deals. We proceed to an in-depth scrutiny of the foundations of synergies using Porter’s model of the value chain. A discernment of the nature of synergies and the mode of their emergence is helpful to clarify to what extent and under which boundary conditions it is appropriate to apply the DCF or the real option techniques for evaluating each type of synergy. Combining both financial tools, the methodology suggested for evaluating the synergies is able to: evaluate projects of M&As, orient the selection of target firms and the definition of the premium of acquisition, and drive…
Sammenhengen mellom mestringsforventning, helserelatert livskvalitet og selvrapportert fysisk aktivitet blant elever i videregående skole
2016
Masteroppgave folkehelsevitenskap - Universitetet i Agder 2016 Background: Two different intervention models were developed to increase participation in physical education in high school, targeting “motion enjoyment” and “sport enjoyment”. Both models are intended to increase the pleasure of physical activity in physical education, as well as to contribute to the development of students’ skills, abilities and increase future commitment. The intention behind the motion enjoyment model is to reinforce positive experiences which are related to physical activity, along with raising the awareness in young people of the health benefits associated with physical activity. The sport enjoyment model …
Genomic structure and promoter analysis of pathogen-inducedrepatgenes fromSpodoptera exigua
2009
The repat gene family encodes midgut proteins overexpressed in response to pathogen infection in the lepidopteran Spodoptera exigua. Up-regulation of repat genes has been observed after challenging the larvae with both Bacillus thuringiensis toxins and after infection with the baculovirus Autographa californica multiple nucleopolyhedrovirus. In our study, PCR amplification of the genomic region and genome walking were used to obtain the genomic structure and the sequence of the 5'-upstream region of repat1 and repat2, two of the most phylogenetically distant members of the repat family. A similar gene structure between repat1 and repat2 has been found, with conserved exon-intron positions a…
Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.
2001
ABSTRACT Studies of the Hepatitis C virus (HCV) replication cycle have been made possible with the development of subgenomic selectable RNAs that replicate autonomously in cultured cells. In these replicons the region encoding the HCV structural proteins was replaced by the neomycin phosphotransferase gene, allowing the selection of transfected cells that support high-level replication of these RNAs. Subsequent analyses revealed that, within selected cells, HCV RNAs had acquired adaptive mutations that increased the efficiency of colony formation by an unknown mechanism. Using a panel of replicons that differed in their degrees of cell culture adaptation, in this study we show that adaptive…