Search results for "predictive"
showing 10 items of 1373 documents
Handgrip strength and depression among 34,129 adults aged 50 years and older in six low- and middle-income countries
2019
Introduction: Handgrip strength is a simple and inexpensive marker of health and mortality risk. It presents an ideal risk-stratifying method for use in low and middle-income countries (LMICs). There are, however, no population-based studies investigating the associations between handgrip strength and depression in LMICs. We aimed to assess these associations among community-dwelling middle-aged and older adults using nationally representative data from six LMICs. Method: Cross-sectional data on individuals aged ≥ 50 years from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. Depression was based on the Composite International Diagnostic Interview. Weak…
Influence of immigration and other factors on caries in 12- and 15-yr-old children.
2007
In recent years the Valencia region has undergone mass immigration, mainly of people from eastern Europe, North Africa, and Latin America. The objective of this study was to assess the effect of immigration on caries prevalence and experience in 12- and 15-yr-old children in the Valencia region, and to relate this to other socio-economic and oral hygiene-related variables. The data were obtained from the epidemiological study of oral health carried out in the Valencia Region in 2004. The study group comprised 478, 12-yr-old children and 401, 15-yr-old children. Immigration status, age, toothbrushing frequency, and intake of cariogenic foods between meals showed significant association in a …
Complementary frailty and mortality prediction models on older patients as a tool for assessing palliative care needs.
2021
Background: Palliative care (PC) has demonstrated benefits for life-limiting illnesses. Cancer patients have mainly accessed these services, but there is growing consensus about the importance of promoting access for patients with non-malignant disease. Bad survival prognosis and patient9s frailty are usual dimensions to decide PC inclusion. Objectives: The main aim of this work is to design and evaluate three quantitative models based on machine learning approaches to predict frailty and mortality on older patients in the context of supporting palliative care decision making: one-year mortality, survival regression and one-year frailty classification. Methods: The dataset used in this stud…
Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases
2010
Abstract Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an increasing proportion in the health care budgets worldwide. However, recent development in modern medicine especially in genetics, proteomics, and informatics is leading to the discovery of biomarkers associated with different CDD that can be used as indicator of disease’s risk in healthy subjects. Therefore, predictive medicine is merging and medical doctors may for t…
Work ability in midlife as a predictor of mortality and disability in later life: a 28-year prospective follow-up study.
2011
Background: Poor work ability correlates with increased morbidity and early retirement from the workforce, but the association in old age is not known. We investigated work ability in midlife among white-collar and blue-collar employees as a predictor of mortality and disability 28 years later. Methods: A total of 5971 occupationally active people aged 44–58 years participated in the Finnish Longitudinal Study of Municipal Employees (FLAME) in 1981. Perceived work ability relative to lifetime best was categorized as excellent, moderate or poor. In 2009, the ability to perform activities of daily living was assessed among 2879 respondents (71.0% of the survivors). Mortality data were availab…
Schöne neue Welt der Prävention? Zu Voraussetzungen und Reichweite von Public Health Genetics
2007
Recent developments in molecular genetics and genomics have not only provided new insights into the biological foundation of life but have also brought about significant changes in the ways health and disease are understood. Nowadays, understanding how the human genome interacts with health-related behaviour and diverse environments is recognised to be the key for biomedical innovation. Even though advances in genetics and genomics have unveiled a whole new complexity of the genetic underpinnings of health and disease and clearly show the need for further investigation, studies of health-related genetic traits already give rise to novel approaches to prevention. As a relatively new field Pu…
Psychometric testing of the Norwegian version of the Nutritional Form For the Elderly among older home-dwelling people
2012
Ulrika Söderhamn, Bjørg Dale, Kari Sundsli, Solveig T Tomstad, Olle SöderhamnCenter for Caring Research, Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, NorwayBackground: Nutritional screening instruments need to be evaluated in terms of reliability and validity and being able to demonstrate sensitivity and specificity for use in clinical practice and research. The aims of this study were to test the reliability and validity of the Norwegian version of the Nutritional Form For the Elderly (NUFFE-NO) in a sample of older home-dwelling people, and to use the short form of the Mini Nutritional Assessment (MNA-SF) as a standard.…
A new approach to modelling the shelf life of Gilthead seabream (Sparus aurata)
2013
Summary A total of 217 Gilthead seabreams were subdivided in four groups, according to four different storage conditions. All fish were evaluated by both Quality Index Method (QIM) and microbiological analysis, sampling skin, gills and flesh, separately. A QIM score predictive system was set by modelling the growth of microflora of skin, gills and flesh and coupling these predictions to each related partial QIM score (QIMSkin, QIMGills, QIMFlesh). The expression of QIM score as a function of bacterial behaviour was carried out by the employment of two coefficients. The predicted mean bacterial concentrations corresponding to the QIM score at 14 days were always near to Log 8 CFU g−1 in the …
Application of an interspecific competition model to predict the growth of Aeromonas hydrophyla on fish surfaces during refrigerated storage (Anwendu…
2007
The growth of Aeromonas hydrophila and the aerobic mesophilic plate count (APC) on gilthead seabream surfaces was evaluated during refrigerated storage (21 days). The related growth curves were compared with those obtained by a conventional third order predictive model obtaining a low agreement between observed and predicted data (Root Mean Squared Error = 1.77 for Aeromonas hydrophila and 0.64 for APC).The Lotka-Volterra interspecific competition model was used in order to calculate the degree of interaction between the two bacterial populations (beta_{Ah/APC} and beta_{APC/Ah}, respectively, the interspecific competition coefficients of APC on Aeromonas hydrophila and vice-versa). Afterwa…
Co-factors, Microbes, and Immunogenetics in Celiac Disease to Guide Novel Approaches for Diagnosis and Treatment.
2021
Celiac disease (CeD) is a frequent immune-mediated disease that affects not only the small intestine but also many extraintestinal sites. The role of gluten proteins as dietary triggers, HLA-DQ2 or -DQ8 as major necessary genetic predisposition, and tissue transglutaminase (TG2) as mechanistically involved autoantigen, are unique features of CeD. Recent research implicates many cofactors working in synergism with these key triggers, including the intestinal microbiota and their metabolites, nongluten dietary triggers, intestinal barrier defects, novel immune cell phenotypes, and mediators and cytokines. In addition, apart from HLA-DQ2 and -DQ8, multiple and complex predisposing genetic fact…