Search results for "predictive"

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collabora…

2018

PubMed: 30270054

Flow-cytometric screening for the modulation of receptor-mediated endocytosis in human dendritic cells: implications for the development of an in vit…

1997

The aim of this study was to explore the usefulness of human blood dendritic cells (DC) in the development of an in vitro model for predictive testing of contact sensitizers. A method was established to monitor the influence of chemicals on the intracellular targeting of antibody-crosslinked MHC class II molecules after their uptake by human DC. Using a three-colour flow-cytometric technique, freshly prepared DC were distinguished from other MHC class II-bearing cell types such as B-cells and monocytes in unseparated mononuclear cell suspensions of healthy volunteers. The assay is based on the pH-sensitivity of internalized fluorescein-coupled MHC class II specific antibodies. Quenching of …

A review of the Digital Twin technology for fault detection in buildings

2022

This study aims to evaluate the utilization of technology known as Digital Twin for fault detection in buildings. The strategy consisted of studying existing applications, difficulties, and possibilities that come with it. The Digital Twin technology is one of the most intriguing newly discovered technologies rapidly evolving; however, some problems still need to be addressed. First, using Digital Twins to detect building faults to prevent future failures and cutting overall costs by improving building maintenance is still ambiguous. Second, how Digital Twin technology may be applied to discover inefficiencies inside the building to optimize energy usage is not well defined. To address thes…

OPTIMIZING STOCHASTIC SUSCEPTIBILITY MODELLING FOR DEBRIS FLOW LANDSLIDES: MODEL EXPORTATION, STATISTICAL TECHNIQUES COMPARISON AND USE OF REMOTE SEN…

Il presente lavoro di ricerca è stato sviluppato al fine di approfondire approcci metodologici nell'ambito della sucscettibilità da frana. In particolare, il tema centrale della ricerca è rappresentato dal tema specifico dell'esportazione spaziale di modelli di suscettibilità nell'area mediterranea. All'interno del topic specifico dell'esportazione di modelli predittivi spaziali sono state approfondite tematiche relative all'utilizzo di differenti algoritmi o di differenti sorgenti, derivate da DEM o da coperture satellitari. The present work has been developed in order to enhance current methodological approaches within the big picture of the landslide susceptibility. In particular, the ce…

Pilot Study on Predictive Value of Plasmatic Levels of 9 Angiogenetic Biomarkers in Selection of Patients Candidate to Prostate Biopsy

2013

To reduce the number of negative prostate biopsies in patients with elevated PSA serum levels represents a major challenge in urological oncology. Angiogenetic factors might be involved in initial stages of prostate cancer and might represent useful tools in patients’ selection for prostate biopsy. The plasmatic levels of Angiopoietin-2, Follistatin, G-CSF, HGF, IL-8, Leptin, PDGF-BB, PECAM-1 and VEGF were measured by BioPlex immunoassay in patients undergoing prostate biopsy for palpable prostate nodule and/or elevated PSA levels (≥4 ng/mL). They were related with biopsy results. ROC curve analysis was exploited to test the diagnostic accuracy of each biomarker by AUC calculation. A poten…

Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene stu…

2016

AbstractContext: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.Objective: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).Methods: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.Results: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.Conclusion: In women with known CAD, increased leptin concentr…

The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC)

2020

Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety. From its discover leptin has been found in different body districts, involved in always new functions and processes. In the last years numerous relationships between leptin and cancer has been found. The aim of this study is to test the leptin positivity in human primitive laryngeal squamous cell carcinoma (SCC) and in its lymph node metastasis. Materials and methods: Leptin positivity was detected by immunohistochemical analysis on pathological samples from 18 patients subjected to laryngectomy and neck dissection for SC…

I saw this somewhere else: the Spanish Ambiguous Words (SAW) database

2017

The present paper describes the Spanish Ambiguous Words (SAW) database, which comprises 210 words (133 polysemous and 77 homographs). Three-hundred and fifteen Spanish university students took part in the study on which SAW is based. First, subjective word meanings and senses were collected by means of a meaning retrieval task. Two judges then assigned participants’ responses to different categories of meaning according to lexicographical and statistical criteria. Results showed that, while there was a relatively high relationship between the number of senses included in the dictionary and those provided by participants (r = .62), regression analyses on lexical decision and naming times rev…

Serum ferritin is a discriminant marker for both fibrosis and inflammation in histologically proven non-alcoholic fatty liver disease patients

2011

INTRODUCTION: Differentiation between steatosis and non-alcoholic steatohepatitis (NASH) in non-alcoholic fatty liver disease (NAFLD) is important as NASH progress to cirrhosis. No specific laboratory/imaging technique exists either to diagnose NASH or to select patients for liver biopsy. PATIENTS AND METHODS: We evaluated serum ferritin and the features of metabolic syndrome with respect to histological inflammation and/or fibrosis in NAFLD patients. The Kleiner scoring system was used to classify NAFLD in consecutive liver biopsies. One hundred and eleven patients: median age 52.6, 64 males, obesity 62, diabetes mellitus (DM) 58, arterial hypertension 26 and hyperlipidaemia 40%. RESULTS: …

Improved noninvasive prediction of liver fibrosis by liver stiffness measurement in patients with nonalcoholic fatty liver disease accounting for con…

2016

Background and aims: Liver stiffness measurement (LSM) frequently overestimates the severity of liver fibrosis In Nonalcoholic Fatty Liver Disease (NAFLD). Controlled Attenuation Parameter (CAP) is a new parameter provided by the same machine used for LSM, and associated with both steatosis and BMI, the two factors mostly affecting LSM peformance in NAFLD. We aimed to determine wheter prediction of liver fibrosis by LSM in NAFLD patients is affected by CAP values. Methods: Patients (n=324) were assessed by clinical and histological (Kleiner score) features. LSM and CAP were performed using the M probe. CAP values were grouped by tertiles (lower from 132 to 298, middle from 299 to 338, highe…