Search results for "predictor"

Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer.

2017

Biological changes that occur during metastatic progression of breast cancer are still incompletely characterized. In this study, we compared intrinsic molecular subtypes and gene expression in 123 paired primary and metastatic tissues from breast cancer patients. Intrinsic subtype was identified using a PAM50 classifier and χ2 tests determined the differences in variable distribution. The rate of subtype conversion was 0% in basal-like tumors, 23.1% in HER2-enriched (HER2-E) tumors, 30.0% in luminal B tumors, and 55.3% in luminal A tumors. In 40.2% of cases, luminal A tumors converted to luminal B tumors, whereas in 14.3% of cases luminal A and B tumors converted to HER2-E tumors. We ident…

Unbiased Branches: An Open Problem

2007

The majority of currently available dynamic branch predictors base their prediction accuracy on the previous k branch outcomes. Such predictors sustain high prediction accuracy but they do not consider the impact of unbiased branches, which are difficult-to-predict. In this paper, we evaluate the impact of unbiased branches in terms of prediction accuracy on a range of branch difference predictors using prediction by partial matching, multiple Markov prediction and neural-based prediction. Since our focus is on the impact that unbiased branches have on processor performance, timing issues and hardware costs are out of scope of this investigation. Our simulation results, with the SPEC2000 in…

2018

In recent decades, the massification and diversification of higher education have generated new challenges for the guidance of university students. The present study focuses on students’ experience...

Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study

2022

INTRODUCTION: Intra-abdominal infections represent the second most frequently acquired infection in the intensive care unit (ICU), with mortality rates ranging from 20% to 50%. Candida spp. may be responsible for up to 10-30% of cases. This study assesses risk factors for development of intra-abdominal candidiasis (IAC) among patients admitted to ICU. METHODS: We performed a case-control study in 26 European ICUs during the period January 2015-December 2016. Patients at least 18 years old who developed an episode of microbiologically documented IAC during their stay in the ICU (at least 48 h after admission) served as the case cohort. The control group consisted of adult patients who did no…

Changes in emotions and personal goals in primiparous pregnant women during group intervention for fear of childbirth

2018

The changes in emotions, subjective fear of childbirth, and personal goals were examined during a group intervention to treat fear of childbirth (FOC). The objective was to gain a more detailed understanding of the changes occurring during the group intervention of FOC. The changes in emotions, subjective FOC, and personal goals were studied in primiparous pregnant women with severe FOC participating in a group intervention (n = 105). The group intervention contained six sessions during pregnancy and one after childbirth. At every session, the participants filled in a questionnaire regarding their experiences of current positive and negative emotions and the subjective FOC. The participants…

What should i do and who's to blame?

2022

The COVID-19 crisis has had a major impact on youth. This study examined factors associated with youth’s attitudes towards their government’s response to the pandemic and their blaming of individuals from certain risk groups, ethnic backgrounds, and countries or regions. In a sample of 5,682 young adults (Mage = 22) from 14 countries, lower perceived burden due to COVID-19, more collectivistic and less individualistic values, and more empathy were associated with more positive attitudes towards the government and less blaming of individuals of certain groups. Youth’s social identification with others in the pandemic mediated these associations in the same direction, apart from the COVID-19 …

An a priori prediction model of response to peginterferon plus ribavirin dual therapy in naïve patients with genotype 1 chronic hepatitis C.

2014

none 29 no Background: Aim was to select naïve patients with genotype 1 chronic hepatitis C having a high probability of response to Peg-interferon. +. ribavirin therapy. Methods: In 1073 patients (derivation cohort), predictors of rapid and sustained virological response were identified by logistic analysis; regression coefficients were used to generate prediction models for sustained virological response. Probabilities at baseline and treatment week 4 were utilized to develop a decision rule to select patients with high likelihood of response. The model was then validated in 423 patients (validation cohort). Results: In the derivation cohort, 257 achieved rapid virological response and 8…

Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol…

2021

Background: Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence.Methods: Sixty-eight hospitalized early-abstinence AD male patients and 68 age- and education-matched healthy controls (HCs) underwent resting-functional magnetic resonance imaging (r-f…

Goal conflict and facilitation as predictors of work–family satisfaction and engagement

2008

Abstract In a study of working adults (N = 131; Mean age = 43.52 yrs; 62 males) in Germany and Finland, the mean level of goal facilitation was found to be significantly higher than that of goal interference. Hence, many individuals seem to be rather successful in constructing a personal goal system that is functional in terms of supportive links. As hypothesized, goal conflict and facilitation were associated with work-related outcomes, especially with work satisfaction. The associations with family-related outcomes were less pronounced when the focus was exclusively on either supportive or interfering goal relationships. However, when the intraindividual relation between goal conflict and…

Prosociality as a mediator between teacher collaboration and turnover intention

2019

PurposeThe purpose of this paper is to investigate the mediating role of prosociality, which is defined in terms of helping and benefitting others, between teacher collaboration and their turnover intentions. Prosociality was measured as prosocial impact and prosocial motivation.Design/methodology/approachThis study was conducted through a cross-sectional survey of 260 elementary and junior high school teachers in Japan. A structural equational model was employed to examine the mediating roles of prosocial impact and prosocial motivation in the relationships between teacher collaboration and their turnover intention.FindingsThe results, first, supported the hypotheses: the high perception o…