Search results for "preeclampsia"
showing 8 items of 48 documents
Factor V Leiden, C>T MTHFR Polymorphism and Genetic Susceptibility to Preeclampsia
1997
SummaryWe performed a case-controlled study to investigate whether the FV Leiden mutation and the C>T677 polymorphism of the 5,10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers were 10 (10.5%) in cases and 3 (2.3%) in controls (OR: 4.9, 95% Cl: 1.3-18.3). MTHFR TT homozygotes were 28 (29.8%) in cases and 24 (18.6%) in the control group (OR: 1.8,95% Cl 1.0-3.5). No difference in any of the polymorphisms was found between proteinuric (n = 45) and non-proteinur-ic (n = 51) patients. Moreover, MTHFR polymorphism does not affect the association betwe…
Pre-pregnancy and early pregnancy dietary behavior in relation to maternal and newborn health in the Norwegian Fit for Delivery study – a post hoc ob…
2018
Background Randomized controlled trials targeting maternal dietary and physical activity behaviors during pregnancy have generally failed to accomplish reductions in the prevalence of adverse maternal and neonatal outcomes. Interventions carried out during pregnancy could thus be missing the mark in maximizing intervention health benefit. Objective To investigate whether pre-pregnancy and early pregnancy dietary behavior as reported at inclusion into the Norwegian Fit for Delivery (NFFD) trial was associated with maternal and neonatal outcomes irrespective of subsequent randomization assignment. Design The study is a post-hoc observational analysis of data from a randomized controlled lifes…
Abstract P153: Early Changes in Left-Atrial and Left-Ventricular Geometry and Function in Women After Preeclampsia as Detected by Cardiac Magnetic Re…
2019
Objectives: Preeclampsia (PE), the leading cause of maternal and neonatal morbidity and mortality, is associated with an increased long-term risk for cardiovascular disease (CVD). We aimed to characterize myocardium and investigate potential functional and structural cardiac alterations in asymptomatic women after PE using cardiovascular magnetic resonance (CMR) imaging. Methods and Results: We performed a post-pregnancy case-control study (clinicaltrials.gov ID: NCT03313063). In total, 22 cases and 23 controls were recruited. Participants were matched by age, BMI and parity. Hemodynamic and morphologic characteristics of the myocardium were assessed using established and innovative CMR te…
Molecular investigation on the etiology of preeclampsia and new strategies for its early diagnosis
2023
Endometrial decidualization is critical for pregnancy establishment and maintenance. This process promotes endometrial remodeling allowing placental cytotrophoblasts (CTBs) invasion up to an appropriate depth to form the maternal-fetal interface. A shallow CTBs invasion compromises healthy pregnancy and it is associated with the development of severe preeclampsia (sPE). Our working hypothesis is that defective decidualization impairs the adaptation of the maternal “soil” ─the decidua─ to be invaded by CTBs and plays a pivotal role in the etiology of sPE. Previously, we have demonstrated the existence of an in vitro defective decidualization of endometrial stromal cells isolated from women w…
Decidualización defectuosa durante y después de un embarazo con preeclampsia revela una contribución materna en la etiología de la enfermedad
2020
La Preeclampsia (PE) es una enfermedad obstétrica caracterizada por hipertensión arterial en gestante previamente normotensa a partir de la semana 20 de gestación con o sin síntomas asociados y con importante morbimortalidad materno-fetal y neonatal asociada. La única cura actual es el alumbramiento. La etiología es desconocida pero hay una decidualización endometrial alterada y una invasión trofoblástica superficial involucrada que produce placentación anómala y desencadena el fenotipo clínico característico. Estudios recientes in vitro demuestran alteración en la expresión de genes involucrados en decidualización como anexina A2 (ANXA2). Esta proteína está presente en la mayoría de célula…
Epigenetic analysis of cell-free DNA as a tool to study pathogenesis and maternal syndrome of preeclampsia
2019
El ADN libre circulante (ADNlc) ha surgido como una valiosa fuente de información en el campo de la biomedicina. En concreto, la existencia de diferencias epigenéticas en el ADNlc entre individuos sanos y enfermos evidencia la utilidad del estudio de estas marcas y su potencial aplicación en enfermedades que no conllevan mutaciones del ADN. La preeclampsia es una complicación del embarazo considerada una de las principales causas de muerte materna alrededor del mundo. A pesar de su gran importancia, su fisiopatología todavía no se conoce con exactitud. Este síndrome representa un modelo de patología sistémica en la que, además de verse comprometida la salud del feto, los efectos sobre la ma…
Respuesta inmunológica en la gestación por ovodonación como factor de riesgo para la preeclampsia
2017
La incidencia de preeclampsia es significativamente mayor en gestaciones por ovodonación en comparación con aquellas con ovocitos propios de la gestante 1-5. Se ha evidenciado una diferente respuesta inmunológica a nivel placentario en gestantes con ovocitos donados en comparación con gestantes con ovocitos propios 1,3,6-9. Por tanto, se ha presentado como hipótesis para el trabajo de tesis doctoral que la respuesta inmunológica materna durante la gestación mediante ovodonación es factor de riesgo para preeclampsia. La primera publicación es una amplia revisión sobre la relación entre la respuesta inmunológica materna durante la gestación y el desarrollo de preeclampsia 10. Revela que, dura…
Preeklampsi i Fit for fødsel
2016
Masteroppgave folkehelsevitenskap - Universitetet i Agder 2016 Background:Preeclampsia is a serious complication of pregnancy, affectingtwo to eight percentages of all pregnanciesworldwide. Important aspects of the causal mechanisms of preeclampsia are still unknown. It is however reason to believe that preeclampsia consists of several subtypes and various causal mechanisms canbe involved. The role of obesity, excessive gestational weight gain and maternal diet in the risk of preeclampsia has recently received increased attention.Thesis question:Are there differences regarding gestational weight gain, select blood sample parametres and dietary habits between primiparous women who develop pr…