Search results for "present"

“My Lies and Liaisons with Marilyn” : An Autofictional Representation of the Downtown Man, a Finnish Successor to the Marlboro Man in the Early 1990s

2022

In this autobiographical/autofictional article, I analyze the representation of masculinity, an advertising poster for a new Finnish cigarette brand from the 1990s recession, when a new man, a “softie,” debuted under the pressure of the traditional male model and the twenty-first-century dudes and lads. The model posing in the poster is a homosexual, me. In the article I ask whether a gay could represent a Finnish man in the early 1990s or only present him. I examine the picture with a queer eye in search of inconsistencies and distortions that break present alternative interpretations to heteronormativity.
 Keywords: homosexuality, masculinity, heteronormativity, advertising, represen…

Email from Nancy Nutsucker

2006

This article addresses the representational conventions and gendered forms of address in online pornography through analysis of 366 unsolicited email (spam) messages advertising porn websites. Combining content description with close reading, it considers the terminology, imagery, narrative elements and points of view employed in advertising commercial heterosexual pornography. The spam advertisements create excessive displays of gender difference. It seems that limited female agency is central, especially in messages advertising reality sites structured by gendered relations of control. Arguing that such displays of control should not be automatically translated as displays of power, this…

Vencida a veces, nunca prisionera. Georgina Herrera y Belkis Ayón: una poética de la autorrepresentación

2013

Resumen: El objetivo de este articulo es analizar la representacion de la mujer negra a traves de la obra de la poetisa cubana Georgina Herrera y la grabadora Belkis Ayon, y el modo en que el discurso referido a su sexualidad, su raza y su genero ha contribuido a formar el imaginario de la identidad nacional. Con el fin de articular el contexto historico y social de la poblacion negra en Cuba, establezco un breve itinerario que parte de mediados del siglo XX  hasta el denominado Periodo Especial en los anos 90 del pasado siglo. El conocimiento de estas diferentes etapas es decisivo para entender la situacion de la mujer negra en Cuba. En una segunda fase, abordo el proceso de autorrepresent…

Modelling and animation of theatrical Greek masks in an authoring system

2007

Social Network Banking : A Case Study of 100 Leading Global Banks

2018

Social media is widely recognized as a challenging new communication technology in both economic and social contexts. The present article explores how banks have exploited this technology in the range of consumer retail banking services offered by 100 leading global banks on the three major social networking sites (SNS): Facebook, Twitter, and YouTube. Viewing social network (SN) banking as a separate delivery channel and offering a working definition of SN banking, the article shows that banks have been more cautious than other businesses in using SNS. The available services are classified on nine main dimensions: marketing, financial education and advice, information support, customer sup…

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion.

2013

Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins. Here we show that HCMV immunoevasins differentially impair T cell recognition of epitopes from the same viral antigen, immediate-early 1 (IE-1), that are presented by different MHC class I allotypes. In the presence of immunoevasins, HLA-A- and HLA-B-restricted T cell clones were ineffective, but HLA-C*0702-restricted T cell clones recognized and killed infected cells. Resistance of HLA-C*0702 to viral immunoevasins US2 and US11 was mediated by the alpha3 domain and C-terminal region …

The efficient bovine insulin presentation capacity of bone marrow-derived macrophages activated by granulocyte-macrophage colony-stimulating factor c…

1993

Bone marrow-derived macrophages (BMM phi) were shown before to function as antigen-presenting cells. We show here, that the antigen presentation capacity of BMM phi depends on the nature of the antigen and is differently regulated by the lymphokines interferon-gamma (IFN-gamma) and granulocyte/macrophage-colony-stimulating factor (GM-CSF). When bovine insulin (BI) was employed as antigen, only BMM phi treated with GM-CSF (GM-CSF-M phi) were efficient presenters, but when presentation of the antigens ovalbumin and conalbumin was tested, IFN-gamma-pulsed BMM phi (IFN-gamma-M phi) proved superior to GM-CSF-M phi. The lack of efficient BI presentation function of IFN-gamma-M phi was only obviou…

Generation of tumor-reactive CTL against the tumor-associated antigen HER2 using retrovirally transduced dendritic cells derived from CD34+ hemopoiet…

2000

Abstract Ag-specific CD8+ CTL are crucial for effective tumor rejection. Attempts to treat human malignancies by adoptive transfer of tumor-reactive CTL have been limited due to the difficulty of generating and expanding autologous CTL with defined Ag specificity. The current study examined whether human CTL can be generated against the tumor-associated Ag HER2 using autologous dendritic cells (DC) that had been genetically engineered to express HER2. DC progenitors were expanded by culturing CD34+ hemopoietic progenitor cells in the presence of the designer cytokine HyperIL-6. Proliferating precursor cells were infected by a retroviral vector encoding the HER2 Ag and further differentiated…

Consequences of antigen self-presentation by tumor-specific cytotoxic T cells.

2000

Abstract CDS-positive cytotoxic T cells (CTL) recognize antigenic peptides in combination with major histocompatibility complex (MHC) class I molecules on the surface of syngeneic antigen presenting cells (APC). In the present paper we show that cells from tumor antigen-specific CTL clones present their cognate antigenic peptide to other CTL from the same clone. Inter-CTL peptide presentation resulted in activation of the cells of one CTL clone to MHC-unrestricted lysis of bystander cells. In contrast to the behaviour of this clone, another CTL clone did not lyse bystander cells after incubation with the cognate peptide, but was activated to self-destruction. The human herpes virus Epstein-…

T cells engineered to express a T-cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice

2015

Background & Aims Cancer therapies are being developed based on our ability to direct T cells against tumor antigens. Glypican-3 (GPC3) is expressed by 75% of all hepatocellular carcinomas (HCC), but not in healthy liver tissue or other organs. We aimed to generate T cells with GPC3-specific receptors that recognize HCC and used them to eliminate GPC3-expressing xenograft tumors grown from human HCC cells in mice. Methods We used mass spectrometry to obtain a comprehensive peptidome from GPC3-expressing hepatoma cells after immune-affinity purification of human leukocyte antigen (HLA)-A2 and bioinformatics to identify immunodominant peptides. To circumvent GPC3 tolerance resulting from feta…