Search results for "prime"
showing 10 items of 853 documents
Maturation of epidermal Langerhans cells: increased expression of beta- and gamma-actin isoforms as a basis of specialized cell functions.
1999
Epidermal Langerhans cells (LC) represent immature dendritic cells. During in vitro culture in the presence of keratinocytes they mature into potent immunostimulatory cells for naive T cells. This process is thought to simulate in vivo maturation of LC following activation by antigen contact. Maturation of LC is accompanied by morphological alterations. Applying a differential screening procedure we isolated differentially expressed cDNAs involved in the maturation events including cDNAs of the cytoskeletal actin isoforms beta- and gamma-actin. Stronger signals with hybridization probes derived from cultured LC compared with probes derived from freshly isolated LC indicate upregulation of a…
Letter-case information and the identification of brand names.
2014
A central tenet of most current models of visual-word recognition is that lexical units are activated on the basis of case-invariant abstract letter representations. Here, we examined this assumption by using a unique type of words: brand names. The rationale of the experiments is that brand names are archetypically printed either in lowercase (e.g., adidas) or uppercase (e.g., IKEA). This allows us to present the brand names in their standard or non-standard case configuration (e.g., adidas, IKEA vs. ADIDAS, ikea, respectively). We conducted two experiments with a brand-decision task (‘is it a brand name?’): a single-presentation experiment and a masked priming experiment. Results in the s…
On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages
2009
AbstractThe generation of cellular diversity in the nervous system involves the mechanism of asymmetric cell division. Besides an array of molecules, including the Par protein cassette, a heterotrimeric G protein signalling complex, Inscuteable plays a major role in controlling asymmetric cell division, which ultimately leads to differential activation of the Notch signalling pathway and correct specification of the two daughter cells. In this context, Notch is required to be active in one sibling and inactive in the other. Here, we investigated the requirement of genes previously known to play key roles in sibling cell fate specification such as members of the Notch signalling pathway, e.g…
Resolving the locus of cAsE aLtErNaTiOn effects in visual word recognition: Evidence from masked priming.
2015
Determining the factors that modulate the early access of abstract lexical representations is imperative for the formulation of a comprehensive neural account of visual-word identification. There is a current debate on whether the effects of case alternation (e.g., tRaIn vs. train) have an early or late locus in the word-processing stream. Here we report a lexical decision experiment using a technique that taps the early stages of visual-word recognition (i.e., masked priming). In the design, uppercase targets could be preceded by an identity/unrelated prime that could be in lowercase or alternating case (e.g., table-TABLE vs. crash-TABLE; tAbLe-TABLE vs. cRaSh-TABLE). Results revealed that…
Suppression of mirror generalization for reversible letters: Evidence from masked priming
2011
Abstract Readers of the Roman script must “unlearn” some forms of mirror generalization when processing printed stimuli (i.e., herb and herd are different words). Here we examine whether the suppression of mirror generalization is a process that affects all letters or whether it mostly affects reversible letters (i.e., b / d ). Three masked priming lexical decision experiments were conducted to examine how the cognitive system processes mirror images of reversible vs. non-reversible letters embedded in Spanish words. Repetition priming effects relative to the mirror-letter condition were substantially greater when the critical letter was reversible (e.g., idea - IDEA vs. ibea - IDEA ) than …
Transposed-letter effects: Consonants, vowels and letter frequency
2008
There is now considerable evidence (e.g., Perea & Lupker, 2003a, 2003b) that transposed-letter nonword primes (e.g., jugde for JUDGE) are more effective primes than replacement-letter nonword primes (e.g., jupte for JUDGE). Recently, Perea and Lupker (2004) demonstrated that, in Spanish, this transposed-letter prime advantage exists only when the transposed letters are consonants (C-C transpositions) and not when they are vowels (V-V transpositions). This vowel-consonant difference causes problems even for models that can successfully explain transposed-letter effects (e.g., SOLAR, Davis, 1999). In Experiment 1 in the present paper, we demonstrated a parallel result in a language with a dif…
The prologue and the fi rst stasimon of Oedipus at Colonus: a comparative study
2017
En este trabajo proponemos un análisis del estásimo primero de la tragedia Edipo en Colono de Sófocles a partir de los versos 16 a 18 del prólogo de la misma obra. La comparación entre ambos pasajes puede ser importante en la medida en que el ἄλσος descrito en el prólogo es presentado como un espacio, dramáticamente importante, que se desarrolla poéticamente en el primer estásimo. Ambas descripciones presentan puntos en común que no sólo pueden ayudarnos a entender mejor la naturaleza de este bosque sagrado, sino también evidencian la programación dramática de los susodichos versos prologales. In this paper we analyze the fi rst stasimon of the tragedy Oedipus at Colonus of Sophocles based …
Neighbourhood distribution interacts with orthographic priming in the lexical decision task
2004
Lexical decision tasks (LDTs) were used with a masked priming procedure to test whether neighbourhood distribution interacts with orthographic priming. Word targets had either ‘single’ neighbours when their two higher frequency orthographic neighbours were spread over letter positions (e.g., neighbours of LOBE: robe-loge) or ‘twin’ neighbours when they were concentrated on a single letter position (e.g., neighbours of FARD: lard-tard). All word targets were preceded by their highest frequency orthographic neighbour or by a control prime. An inhibitory priming effect was found for words with single neighbours, but not for words with twin neighbours, in both a yes/no LDT (Experiment 1a) and a…
Interethnic studies of TNF polymorphisms confirm the likely presence of a second MHC susceptibility locus in ankylosing spondylitis
2000
The objective of this study was to investigate TNF promoter region polymorphisms for association with susceptibility to ankylosing spondylitis (AS). The TNF -238 and -308 polymorphisms were genotyped in 306 English AS cases and 204 ethnically matched healthy B27-positive controls, and 96 southern German AS cases, 58 B27-positive and 251 B27-negative ethnically matched controls. Additionally, the TNF -376 polymorphism was genotyped in the southern German cases and controls. In the southern German AS patients a significant reduction in TNF -308.2 alleles was seen, compared with B27 positive controls (odds ratio 0.4, P = 0.03, 95% confidence interval 0.2-0.9), but no difference in allele frequ…
Molecular phylogeny of the extinct cave lion Panthera leo spelaea.
2004
To reconstruct the phylogenetic position of the extinct cave lion (Panthera leo spelaea), we sequenced 1 kb of the mitochondrial cytochrome b gene from two Pleistocene cave lion DNA samples (47 and 32 ky B.P.). Phylogenetic analysis shows that the ancient sequences form a clade that is most closely related to the extant lions from Africa and Asia; at the same time, cave lions appear to be highly distinct from their living relatives. Our data show that these cave lion sequences represent lineages that were isolated from lions in Africa and Asia since their dispersal over Europe about 600 ky B.P., as they are not found among our sample of extant populations. The cave lion lineages presented h…