Search results for "proPO"
showing 10 items of 1325 documents
DgCox: a differential geometric approach for high-dimensional Cox proportional hazard models
2014
Many clinical and epidemiological studies rely on survival modelling to detect clinically relevant factors that affect various event histories. With the introduction of high-throughput technologies in the clinical and even large-scale epidemiological studies, the need for inference tools that are able to deal with fat data-structures, i.e., relatively small number of observations compared to the number of features, is becoming more prominent. This paper will introduce a principled sparse inference methodology for proportional hazards modelling, based on differential geometrical analyses of the high-dimensional likelihood surface.
0109 Health effects of exposure to arsenic: a 39 years cohort study in manfredonia, italy
2017
Background On September 26th 1976 an accident occurred in a chemical plant located in Manfredonia (Apulia region, Italy) where Caprolactam (plastic) and Urea (fertilisers) were produced. More than 12 tons of arsenic compounds, used in the production of Urea, were released in the atmosphere, contaminating the plant and surrounding areas. Our study investigates late effects of arsenic exposure among workers present on the day of the accident and during the site clearance. Methods We performed a historical cohort study including 1467 workers (39 females). Follow-up was performed by contacting municipalities of residence in Italy. Death certificates were collected. End of follow-up was either d…
La proporzionalità, l'isola non trovata e la stella polare della Corte costituzionale
2018
L'intervento muove dall'analisi delle più recenti sentenze della Corte costituzionale e della Corte europea dei diritti dell'uomo per tentare di ricavare indicazioni utili a descrivere in modo univoco lo statuto concettuale del principio di proporzionalità. L'osservazione dei dati giurisprudenziali induce tuttavia a ritenere che la proporzione possa offrire migliori capacità di prestazione ove la si intenda, piuttosto che come generale criterio di legittimazione dell’intervento punitivo, quale criterio di delegittimazione che opponga le istanze del costituzionalismo penale alla pretesa sanzionatoria statale. In altre parole, nel ragionare intorno al concetto di proporzionalità/ragionevolezz…
Avvertenze per il consumatore e obblighi delle piattaforme del commercio elettronico: alcune osservazioni sulla sentenza Lee v. Amazon
2022
La Proposition 5 è una legge californiana che attribuisce ai consumatori il diritto ad essere informati circa l’esposizione a sostanze cancerogene o che possano dar luogo a malformazioni congenite o ad altri danni riproduttivi: ai sensi della legge, tutti gli attori del circuito distributivo sono tenuti a fornire un’avvertenza «chiara e ragionevole» del relativo rischio. La sezione 230 del Communications Decency Act esonera da responsabilità gli intermediari della rete relativamente ai contenuti dei terzi. Le piattaforme del commercio elettronico, nel facilitare l’interazione di venditori ed acquirenti, rischiano di mettere a repentaglio la salute dei consumatori, portando loro prodotti vie…
Power of Paradox: Grassroots Organizations’ Legitimacy Strategies Over Time
2021
Fringe stakeholders with limited resources, such as grassroots organizations (GROs), are often ignored in business and society literature. We develop a conceptual framework and a set of propositions detailing how GROs strategically gain legitimacy and influence over time. We argue that GROs encounter specific paradoxes over the emergence, development, and resolution of an issue, and they address these paradoxes using cognitive, moral, and pragmatic legitimacy strategies. While cognitive and moral strategies tend to be used consistently, the flexible and paradoxical use of pragmatic strategies has important consequences, both for GROs’ legitimacy and for their potential influence over powerf…
Creer que p. Consideraciones en torno a la creencia
2012
This article is intended as a contribution to our understanding of the nature of belief as a propositional attitude. After contextualizing the issue, we discuss and reject some accounts of belief as a gamble and as high (near to 1) subjective probability and argue for the claim that believing that p consists in merely attributing a higher subjective probability to p than to not-p being not-p any of p"s alternatives and all of them as a whole. Additionally, we propose that the question which a belief answers is crucial in order to determine the degree of belief and the reasons in its favor. Este artículo trata de profundizar en nuestra comprensión de la naturaleza de la creencia en tanto que…
The conceptualisation of austerity in the Portuguese, Spanish and Irish press
2017
The aim of this chapter is to analyse the conceptualisation of austerity in three different European cultures by identifying metaphorical expressions used in one representative newspaper of the Portuguese, the Spanish and the Irish press between 2011 and 2012. The metaphors were identified by searching for three keywords from the field of economy and politics (austeridade-austeridad-austerity, corte-recorte-cut and divida-deuda-debt) and were then classified according to the type of schema they instantiate, namely, propositional schema, image schema or event schema. Assuming the general framework of Cultural Linguistics and corpus-based and discourse-based approaches to conceptual metaphor,…
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
2009
Abstract Purpose: We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling. Experimental Design: The expression levels of cyclins B1, D1, and E1 were quantified in 779 breast tumors and 53 cell lines using reverse phase protein arrays and/or transcriptional profiling. Results: Whereas cyclin E1 overexpression was a specific marker of triple-negative and basal-like tumors, cyclin B1 overexpression occurred in poor prognosis hormone receptor–positive, luminal B and basal-like breast cancers. Cyclin D1 overexpression occurred in lum…
Retrograde in situ versus antegrade pulmonary preservation in clinical lung transplantation: a single-centre experience.
2014
OBJECTIVE Experimental and clinical studies have indicated a beneficial effect of retrograde lung preservation on post-transplant results. Accordingly, we conducted a non-randomized trial. METHODS A total of 209 consecutive recipients transplanted with low-potassium dextrane (LPD)-preserved lungs were eligible for analysis. Antegrade lung preservation (AP) was performed in 173 patients and retrograde in situ perfusion (RP) in 36 patients using low-potassium dextrane solution in all cases. The prostacycline was added to preservation solution. RESULTS The main donor, graft and recipient characteristics did not differ significantly between groups. There was a beneficial trend toward improved o…
Maternal adiposity in pregnancy and offspring asthma in adulthood.
2018
High maternal body mass index in pregnancy was associated with an increased prevalence of offspring asthma in men in adult life