Search results for "probability"
showing 10 items of 3417 documents
Wait-and-switch stochastic model of the non-Debye relaxation. Derivation of the Burr survival probability
2006
Abstract Stochastic mechanism of relaxation, in which a dipole waits until a favourable condition for reorientation exists, is discussed. Assuming that an imposed direction of a dipole moment may be changed when a migrating defect reaches the dipole, we present a mathematically rigorous scheme relating the local random characteristics of a macroscopic system to its effective relaxation behaviour. We derive a relaxation function (the Burr survival probability) that is characterized by the stretched exponential or the power-law behaviour.
Product and moment formulas for iterated stochastic integrals (associated with Lévy processes)
2019
In this paper, we obtain explicit product and moment formulas for products of iterated integrals generated by families of square integrable martingales associated with an arbitrary Levy process. We...
Multicanonical Monte Carlo simulations
1998
Canonical Monte Carlo simulations of disordered systems like spin glasses and systems undergoing first-order phase transitions are severely hampered by rare event states which lead to exponentially diverging autocorrelation times with increasing system size and hence to exponentially large statistical errors. One possibility to overcome this problem is the multicanonical reweighting method. Using standard local update algorithms it could be demonstrated that the dependence of autocorrelation times on the system size V is well described by a less divergent power law, τ∝Vα, with 1<α<3, depending on the system. After a brief review of the basic ideas, combinations of multicanonical reweighting…
CARE: context-aware sequencing read error correction.
2020
Abstract Motivation Error correction is a fundamental pre-processing step in many Next-Generation Sequencing (NGS) pipelines, in particular for de novo genome assembly. However, existing error correction methods either suffer from high false-positive rates since they break reads into independent k-mers or do not scale efficiently to large amounts of sequencing reads and complex genomes. Results We present CARE—an alignment-based scalable error correction algorithm for Illumina data using the concept of minhashing. Minhashing allows for efficient similarity search within large sequencing read collections which enables fast computation of high-quality multiple alignments. Sequencing errors ar…
On stability issues in deriving multivariable regression models
2014
In many areas of science where empirical data are analyzed, a task is often to identify important variables with influence on an outcome. Most often this is done by using a variable selection strategy in the context of a multivariable regression model. Using a study on ozone effects in children (n = 496, 24 covariates), we will discuss aspects relevant for deriving a suitable model. With an emphasis on model stability, we will explore and illustrate differences between predictive models and explanatory models, the key role of stopping criteria, and the value of bootstrap resampling (with and without replacement). Bootstrap resampling will be used to assess variable selection stability, to d…
Power and Type I Error of the Mean and Covariance Structure Analysis Model for Detecting Differential Item Functioning in Graded Response Items.
2016
In this simulation study, we investigate the power and Type I error rate of a procedure based on the mean and covariance structure analysis (MACS) model in detecting differential item functioning (DIF) of graded response items with five response categories. The following factors were manipulated: type of DIF (uniform and non-uniform), DIF magnitude (low, medium and large), equality/inequality of latent trait distributions, sample size (100, 200, 400, and 800) and equality or inequality of the sample sizes across groups. The simulated test was made up of 10 items, of which only 1 contained DIF. One hundred replications were generated for each simulated condition. Results indicate that the MA…
Multiple Comparisons of Treatments with Stable Multivariate Tests in a Two‐Stage Adaptive Design, Including a Test for Non‐Inferiority
2000
The application of stabilized multivariate tests is demonstrated in the analysis of a two-stage adaptive clinical trial with three treatment arms. Due to the clinical problem, the multiple comparisons include tests of superiority as well as a test for non-inferiority, where non-inferiority is (because of missing absolute tolerance limits) expressed as linear contrast of the three treatments. Special emphasis is paid to the combination of the three sources of multiplicity - multiple endpoints, multiple treatments, and two stages of the adaptive design. Particularly, the adaptation after the first stage comprises a change of the a-priori order of hypotheses.
Some extensions of multivariate sliced inverse regression
2007
Multivariate sliced inverse regression (SIR) is a method for achieving dimension reduction in regression problems when the outcome variable y and the regressor x are both assumed to be multidimensional. In this paper, we extend the existing approaches, based on the usual SIR I which only uses the inverse regression curve, to methods using properties of the inverse conditional variance. Contrary to the existing ones, these new methods are not blind for symmetric dependencies and rely on the SIR II or SIRα. We also propose their corresponding pooled slicing versions. We illustrate the usefulness of these approaches on simulation studies.
Gaussian component mixtures and CAR models in Bayesian disease mapping
2012
Hierarchical Bayesian models involving conditional autoregression (CAR) components are commonly used in disease mapping. An alternative model to the proper or improper CAR is the Gaussian component mixture (GCM) model. A review of CAR and GCM models is provided in univariate settings where only one disease is considered, and also in multivariate situations where in addition to the spatial dependence between regions, the dependence among multiple diseases is analyzed. A performance comparison between models using a set of simulated data to help illustrate their respective properties is reported. The results show that both in univariate and multivariate settings, both models perform in a comp…
Some links between conditional and coregionalized multivariate Gaussian Markov random fields
2020
Abstract Multivariate disease mapping models are attracting considerable attention. Many modeling proposals have been made in this area, which could be grouped into three large sets: coregionalization, multivariate conditional and univariate conditional models. In this work we establish some links between these three groups of proposals. Specifically, we explore the equivalence between the two conditional approaches and show that an important class of coregionalization models can be seen as a large subclass of the conditional approaches. Additionally, we propose an extension to the current set of coregionalization models with some new unexplored proposals. This extension is able to reproduc…