Search results for "probability"
showing 10 items of 3417 documents
A note on Malliavin smoothness on the Lévy space
2017
We consider Malliavin calculus based on the Itô chaos decomposition of square integrable random variables on the Lévy space. We show that when a random variable satisfies a certain measurability condition, its differentiability and fractional differentiability can be determined by weighted Lebesgue spaces. The measurability condition is satisfied for all random variables if the underlying Lévy process is a compound Poisson process on a finite time interval. peerReviewed
M-Centrality: identifying key nodes based on global position and local degree variation
2023
Identifying influential nodes in a network is a major issue due to the great deal of applications concerned, such as disease spreading and rumor dynamics. That is why, a plethora of centrality measures has emerged over the years in order to rank nodes according to their topological importance in the network. Local metrics such as degree centrality make use of a very limited information and are easy to compute. Global metrics such as betweenness centrality exploit the information of the whole network structure at the cost of a very high computational complexity. Recent works have shown that combining multiple metrics is a promising strategy to quantify the node's influential ability. Our wor…
A comprehensive conceptual and bibliometric study of person-centered methodologies
2021
AbstractPerson-centered approaches, such as latent profile analysis (LPA) and qualitative comparative analysis (QCA), have gained in popularity in organizational scholarship because of their ability to provide insight into how interrelations between a group of conditions can lead to a particular outcome. Despite the growing acceptance of person-centered approaches in social science research, traditional variable-centered approaches continue to prevail, although their dominance is increasingly questioned. This paper offers in-depth analysis of the current state of QCA and LPA from both a conceptual and a bibliometric perspective. This study thus aims to contextualize the role of person-cente…
A decision support system methodology for forecasting of time series based on soft computing
2006
Exponential procedures are widely used as forecasting techniques for inventory control and business planning. A number of modifications to the generalized exponential smoothing (Holt-Winters) approach to forecasting univariate time series is presented, which have been adapted into a tool for decision support systems. This methodology unifies the phases of estimation and model selection into just one optimization framework which permits the identification of robust solutions. This procedure may provide forecasts from different versions of exponential smoothing by fitting the updated formulas of Holt-Winters and selects the best method using a fuzzy multicriteria approach. The elements of the…
kmcEx: memory-frugal and retrieval-efficient encoding of counted k-mers.
2018
Abstract Motivation K-mers along with their frequency have served as an elementary building block for error correction, repeat detection, multiple sequence alignment, genome assembly, etc., attracting intensive studies in k-mer counting. However, the output of k-mer counters itself is large; very often, it is too large to fit into main memory, leading to highly narrowed usability. Results We introduce a novel idea of encoding k-mers as well as their frequency, achieving good memory saving and retrieval efficiency. Specifically, we propose a Bloom filter-like data structure to encode counted k-mers by coupled-bit arrays—one for k-mer representation and the other for frequency encoding. Exper…
ArtiFuse—computational validation of fusion gene detection tools without relying on simulated reads
2019
Abstract Motivation Gene fusions are an important class of transcriptional variants that can influence cancer development and can be predicted from RNA sequencing (RNA-seq) data by multiple existing tools. However, the real-world performance of these tools is unclear due to the lack of known positive and negative events, especially with regard to fusion genes in individual samples. Often simulated reads are used, but these cannot account for all technical biases in RNA-seq data generated from real samples. Results Here, we present ArtiFuse, a novel approach that simulates fusion genes by sequence modification to the genomic reference, and therefore, can be applied to any RNA-seq dataset wit…
A spatial analysis of Italian unemployment differences
2008
Using spatial econometric models, this paper focuses attention on the spatial structure of provincial unemployment disparities of Italian provinces for the year 2003. On the basis of findings from the economic literature and of the available socio-economic data, various model specifications including supply- and demand-side variables are tested. Further we use ESDA analysis as equivalent to integration analysis on time series; therefore it is applied on each variable, dependent and independent, involved in the statistical model. The suggestions of ESDA lead us to the most adequate statistical model, which estimates indicate that there is a significant degree of neighbouring effect (i.e. pos…
A comparison of nonparametric methods in the graduation of mortality: Application to data from the Valencia Region (Spain)
2006
[EN] The nonparametric graduation of mortality data aims to estimate death rates by carrying out a smoothing of the crude rates obtained directly from original data. The main difference with regard to parametric models is that the assumption of an age-dependent function is unnecessary, which is advantageous when the information behind the model is unknown, as one cause of error is often the choice of an inappropriate model. This paper reviews the various alternatives and presents their application to mortality data from the Valencia Region, Spain. The comparison leads us to the conclusion that the best model is a smoothing by means of Generalised Additive Models (GAM) with splines. The most…
Fully Bayesian Approach to Image Restoration with an Application in Biogeography
1994
SUMMARY A common method of studying biogeographical ranges is an atlas survey, in which the research area is divided into a square grid and the data consist of the squares where observations occur. Often the observations form only an incomplete map of the true range, and a method is required to decide whether the blank squares indicate true absence or merely a lack of study there. This is essentially an image restoration problem, but it has properties that make the common empirical Bayesian procedures inadequate. Most notably, the observed image is heavily degraded, causing difficulties in the estimation of spatial interaction, and the assessment of reliability of the restoration is emphasi…
Antibacterial Activity of Flavonoids Against Methicillin-resistant Staphylococcus aureus strains
2000
An experimental and theoretical study was performed on the anti-staphylococcal activity of 18 natural and synthetic flavonoids against methicillin-resistant Staphylococcus aureus strains. The analysed flavonoids belong to three well-differentiated structural patterns: chalcones, flavanones and flavones. The quantitative analysis of the anti-staphylococcal activity of the compounds was carried out by determining their percent inhibition degree. The hierarchical cluster analysis method was used to analyse the anti-MRSA activity of the compounds. With this methodology, the flavonoids were classified into four groups according to their anti-staphylococcal activity (high, sufficient, intermediat…