Search results for "processi"
showing 10 items of 9638 documents
Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients
2007
Gene polymorphisms in the mammalian biological clock system influence individual rhythms. A single nucleotide polymorphism (SNP) in the 3' flanking region of CLOCK (3111 T/C; rs1801260) influenced diurnal preference in healthy humans and caused sleep phase delay and insomnia in patients affected by bipolar disorder. Genes of the biological clock are expressed in many brain structures other than in the 'master clock' suprachiasmatic nuclei. These areas, such as cingulate cortex, are involved in the control of many human behaviors. Clock genes could then bias 'nonclock' functions such as information processing and decision making. Thirty inpatients affected by a major depressive episode under…
Spatial resolution of fMRI in the human parasylvian cortex: Comparison of somatosensory and auditory activation
2005
Abstract In spite of its outstanding spatial resolution, the biological resolution of functional MRI may be worse because it depends on the vascular architecture of the brain. Here, we compared the activation patterns of the secondary somatosensory and parietal ventral cortex (SII/PV) with that of the primary auditory cortex and adjacent areas (AI/AII). These two brain regions are located immediately adjacent to each other on opposite banks of the Sylvian fissure, and are anatomically and functionally distinct. In 12 healthy subjects, SII/PV was activated by pneumatic tactile stimuli applied to the index finger (0.5 cm 2 contact area, 4 bar pressure), and AI/AII by amplitude-modulated tones…
Distributed BOLD-response in association cortex vector state space predicts reaction time during selective attention.
2006
Human cortical information processing is thought to be dominated by distributed activity in vector state space (Churchland, P.S., Sejnowski, T.J., 1992. The Computational Brain. MIT Press, Cambridge.). In principle, it should be possible to quantify distributed brain activation with independent component analysis (ICA) through vector-based decomposition, i.e., through a separation of a mixture of sources. Using event-related functional magnetic resonance imaging (fMRI) during a selective attention-requiring task (visual oddball), we explored how the number of independent components within activated cortical areas is related to reaction time. Prior to ICA, the activated cortical areas were d…
Bodily self-relatedness in vicarious touch is reflected at early cortical processing stages.
2019
Studies have suggested that there is a strong link between the bodily self and the mechanisms underlying vicarious representations. Here, we used somatosensory ERPs to investigate the temporal dynamics of vicarious touch for stimuli that are more or less related to one's own body (human hands vs. rubber gloves). We found that vicarious touch effects were restricted to self-relatable events (human hands) at early implicit stages of somatosensory processing (P45). At later more cognitive stages of processing (late positive complex, LPC), the vicarious touch effect was stronger for self-relatable events (touch on human hands) than nonself-relatable events (touch on rubber gloves) but present f…
Numbers and time doubly dissociate
2011
The magnitude dimensions of number, time and space have been suggested to share some common magnitude processing, which may imply symmetric interaction among dimensions. Here we challenge these suggestions by presenting a double dissociation between two neuropsychological patients with left (JT) and right (CB) parietal lesions and selective impairment of number and time processing respectively. Both patients showed an influence of task-irrelevant number stimuli on time but not space processing. In JT otherwise preserved time processing was severely impaired in the mere presence of task-irrelevant numbers, which themselves could not be processed accurately. In CB, impaired temporal estimatio…
The EEG and fMRI signatures of neural integration: An investigation of meaningful gestures and corresponding speech
2015
Abstract One of the key features of human interpersonal communication is our ability to integrate information communicated by speech and accompanying gestures. However, it is still not fully understood how this essential combinatory process is represented in the human brain. Functional magnetic resonance imaging (fMRI) studies have unanimously attested the relevance of activation in the posterior superior temporal sulcus/middle temporal gyrus (pSTS/MTG), while electroencephalography (EEG) studies have shown oscillatory activity in specific frequency bands to be associated with multisensory integration. In the current study, we used fMRI and EEG to separately investigate the anatomical and o…
Yes, you can? A speaker’s potency to act upon his words orchestrates early neural responses to message-level meaning
2013
Evidence is accruing that, in comprehending language, the human brain rapidly integrates a wealth of information sources-including the reader or hearer's knowledge about the world and even his/her current mood. However, little is known to date about how language processing in the brain is affected by the hearer's knowledge about the speaker. Here, we investigated the impact of social attributions to the speaker by measuring event-related brain potentials while participants watched videos of three speakers uttering true or false statements pertaining to politics or general knowledge: a top political decision maker (the German Federal Minister of Finance at the time of the experiment), a well…
Capturing the musical brain with Lasso: Dynamic decoding of musical features from fMRI data.
2013
We investigated neural correlates of musical feature processing with a decoding approach. To this end, we used a method that combines computational extraction of musical features with regularized multiple regression (LASSO). Optimal model parameters were determined by maximizing the decoding accuracy using a leave-one-out cross-validation scheme. The method was applied to functional magnetic resonance imaging (fMRI) data that were collected using a naturalistic paradigm, in which participants' brain responses were recorded while they were continuously listening to pieces of real music. The dependent variables comprised musical feature time series that were computationally extracted from the…
Don't stress, it's under control: Neural correlates of stressor controllability in humans
2021
Abstract Animal research has repeatedly shown that control is a key variable in the brain's stress response. Uncontrollable stress triggers a release of monoamines, impairing prefrontal functions while enhancing subcortical circuits. Conversely, control over an adverse event involves prefrontally mediated downregulation of monoamine nuclei and is considered protective. However, it remains unclear to what extent these findings translate to humans. During functional magnetic resonance imaging, we subjected participants to controllable and uncontrollable aversive but non-painful electric stimuli, as well as to a control condition without aversive stimulation. In each trial, a symbol signalled …
The time line of threat processing and vagal withdrawal in response to a self-threatening stressor in cognitive avoidant copers: evidence for vigilan…
2010
Using a spatial cueing paradigm with emotional and neutral facial expressions as cues, we examined early and late patterns of information processing in cognitive avoidant coping (CAV). Participants were required to detect a target that appeared either in the same location as the cue (valid) or in a different location (invalid). Cue–target onset asynchrony (CTOA) was manipulated to be short (250 ms) or long (750 ms). CAV was associated with early facilitation and faster disengagement from angry faces. No effects were found for happy or neutral faces. After completing the spatial cueing task, participants prepared and delivered a public speech and heart rate variability (HRV) was recorded. Di…