Search results for "program"
showing 10 items of 5938 documents
Models and algorithms for berth allocation problems in port terminals
2017
Seaports play a key role in maritime commerce and the global market economy. Goods of different kinds are carried in specialized vessels whose handling requires ad hoc port facilities. Port terminals comprise the quays, infrastructures, and services dedicated to handling the inbound and outbound cargo carried on vessels. Increasing seaborne trade and ever-greater competition between port terminals to attract more traffic have prompted new studies aimed at improving their quality of service while reducing costs. Most terminals implement operational planning to achieve more efficient usage of resources, and this poses new combinatorial optimization problems which have attracted increasing att…
Fundamentos de Optimización Matemática en Economía
1999
La optimización matemática es un área dentro de las matemáticas que se encarga de la elección de la mejor alternativa de entre las posibles para un problema formulado en términos matemáticos. Este área de las matemáticas es muy amplia, debido a la diversidad de situaciones que se pueden plantear y a las distintas maneras de enfocar la resolución del problema. El presente texto, en la medida que pretende ser una herramienta para el análisis económico, se centra en la programación no lineal y en los métodos analíticos de resolución de esos problemas. Por tanto, el objetivo es proporcionar al lector los conocimientos básicos y avanzados de optimización matemática que destacan por su aplicabili…
An Oral History of Programming Practices: Gender and Age Dynamics and Digital (Dis)Engagement Among Computer Programmers in Finland
2015
Since the 1980s, educational policies in many countries have aimed at improving the computer literacy and programming competencies of the population. Over the same period, the possibilities that people have seen regarding programming and everyday programming practices have emerged as an area of strong interest within historical scholarship. The paper contributes to these discussions by drawing on techniques of oral history to focus on programming hobbies and practices in Finland. Examining data from a massive survey of computer hobbyists (N = 1,453) and their recollections about personal computer use (largely during the 1980s), the paper gathers new information on what leads to people’s pur…
Mathematical and Coding Lessons Based on Creative Origami Activities
2019
AbstractThis paper considers how creativity and creative activities can be encouraged in regular mathematical classes by combining different teaching approaches and academic disciplines. We combined origami and paper folding with fractals and their mathematical properties as well as with coding in Scratch in order to facilitate learning mathematics and computer science. We conducted a case study experiment in a Serbian school with 15 high school students and applied different strategies for learning profound mathematical and coding concepts such as fractals dimension and recursion. The goal of the study was to employ creative activities and examine students’ activities during this process i…
Asymptotic Lipschitz regularity for tug-of-war games with varying probabilities
2018
We prove an asymptotic Lipschitz estimate for value functions of tug-of-war games with varying probabilities defined in $\Omega\subset \mathbb R^n$. The method of the proof is based on a game-theoretic idea to estimate the value of a related game defined in $\Omega\times \Omega$ via couplings.
Nueva estrategia para la derivación de hepatocitos funcionales de mujeres afectas de deficiencia en ornitina transcarbamilasa
2022
La DOTC es una enfermedad ligada al sexo (Cromosoma X) que se incluye dentro de un grupo de enfermedades denominadas trastornos del ciclo de la urea. Es un trastorno metabólico cuyo resultado es la acumulación de amonio en la sangre produciéndose episodios hiperamonemia con diferentes grados de severidad. Esto sucede como consecuencia de una mutación en el gen de la OTC, perdiéndose dicha actividad enzimática. La forma más letal de DOTC sucede en el periodo perinatal, y aunque en la actualidad existen tratamientos como dietas bajas en proteínas, o administración de fármacos como los “scavengers” de amonio, estos no suponen una solución en pacientes pediátricos con síntomas graves y crónicos…
Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation
2009
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …
UV-B exposure causes DNA damage and changes in protein expression in northern pike (Esox lucius) posthatched embryos.
2012
The ongoing anthropogenically caused ozone depletion and climate change has increased the amount of biologically harmful UV-B radiation, which is detrimental to fish in embryonal stages. The effects of UV-B radiation on the levels and locations of DNA damage manifested as cyclobutane pyrimidine dimers (CPDs), heat shock protein 70 (HSP70) and p53 protein in newly hatched embryos of pike were examined. Pike larvae were exposed in the laboratory to current and enhanced doses of UV-B radiation. UV-B exposure caused the formation of CPDs in a fluence rate-dependent manner, and the CPDs were found deeper in the tissues with increasing fluence rates. UV-B radiation induced HSP70 in epidermis, and…
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…
2012
The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…
Implantación de un Programa de Optimización de Antimicrobianos en una unidad de pacientes críticos
2018
Introducción: La optimización del tratamiento antimicrobiano es un elemento clave para mejorar la respuesta al tratamiento de los pacientes con infecciones graves, reducir el riesgo de eventos adversos asociados a los mismos y minimizar la generación y selección de cepas bacterianas multirresistentes. Durante la última década, los programas de optimización de antimicrobianos (PROA) han surgido como herramientas de gran utilidad para garantizar el uso racional de los mismos. No obstante, la experiencia descrita sobre su implantación en las unidades de pacientes críticos es reducida. Por otro lado, en un entorno de recursos limitados, se hace necesario evaluar el impacto de este tipo de progr…