Search results for "programme"
showing 10 items of 874 documents
Plastid-nuclear complexes in the photosynthesizing cells from their mitosis up to programmed death
2013
Permanent plastid-nuclear complexes (PNCs) exist in tobacco cells from their mitosis up to programmed cell death (PCD). PNCs in senescing cells of tobacco leaves were typical by enclosure of peroxisomes and mitochondria among chloroplasts which were in contact with nucleus. Such a complex position provides simultaneous interaction of these organelles and direct regulation of metabolism and PCD avoiding the cytosol.
Impact Of Hypoxic And Acidic Extracellular Conditions On Cytotoxicity Of Chemotherapeutic Drugs
2007
In the microenvironment of solid growing tumors, pronounced hypoxia or extracellular acidosis is commonly found The aim of this study was the analysis of the cytotoxic effect of different chemotherapeutic agents (cisplatin, daunorubicin, docetaxel) under these conditions in vitro Prostate carcinoma cells (R3327-AT1) were exposed to hypoxia (pO 2 05 mmHg) or extracellular acidosis (pH=66) for 6h After 3h, cytotoxic drugs were added The cytotoxic effect was assessed by measuring caspase 3-activity (apoptosis), LDH release (necrosis) and repopulation of the cells after chemotherapy (cell death) Compared to aerobic control conditions, severe hypoxia over 6h per se led to a slight increase in ap…
Impact of Hypoxia-Related Tumor Acidosis on Cytotoxicity of Different Chemotherapeutic Drugs In Vitro and In Vivo
2014
Extracellular acidosis in tumors leads to an activation of the p-glycoprotein (Pgp) drug transporter. In the present study the cytotoxicity of different chemotherapeutic drugs and its dependence on the Pgp activity during acidosis were analyzed in vitro and in vivo. Treating R3327-AT1, Pgp-positive tumor cells at pH 7.4 with daunorubicin, cisplatin or docetaxel led to marked apoptosis induction and cell death. Under acidic (pH 6.6) conditions cytotoxicity of daunorubicin or docetaxel was significantly reduced whereas cisplatin-induced cell death was almost pH-independent. Inhibiting Pgp with verapamil reversed the acidosis-induced chemoresistance against daunorubicin and docetaxel. The Pgp …
Analysis and Visualization of Product Memory Layout in IP-XACT
2017
Modern ASIC and FPGA based embedded products use model based design, in which both hardware and software are developed in parallel. Previously HW was completed first and the information handed over to SW team, typically in the form of register tables. The information was even manually copied to SW code, making any changes error-prone and laborious. IP-XACT is the most feasible standard to model HW also for the SW needs. The HW design connectivity and overall memory layout may change due to component instantiations, configurations and conditional operation states, which makes it difficult to create register tables even for documentation. Current register design tools fall short in serving th…
Sociologie de l'école : 6ème édition
2022
Cette 6eédition, totalement réactualisée, d’un manuel devenu « la » référence sur le monde de l’école, des élèves et des enseignants, explore le domaine de manière systématique et objective, et sous des aspects divers : place de l’école dans la société (politiques scolaires, inégalités de carrière, enjeux de la réussite scolaire, évolution des analyses théoriques), mais aussi acteurs et pratiques (profession enseignante, programmes, pratiques éducatives des familles, métiers d’élève).L’ouvrage propose ainsi de nombreux éléments sur les effets des politiques éducatives, la construction et les effets de ségrégation scolaire, ou encore les changements introduits par le renouvellement des ensei…
Dark matter results from 225 live days of XENON100 data
2012
We report on a search for particle dark matter with the XENON100 experiment, operated at the Laboratori Nazionali del Gran Sasso (LNGS) for 13 months during 2011 and 2012. XENON100 features an ultra-low electromagnetic background of (5.3 \pm 0.6) \times 10^-3 events (kg day keVee)^-1 in the energy region of interest. A blind analysis of 224.6 live days \times 34 kg exposure has yielded no evidence for dark matter interactions. The two candidate events observed in the pre-defined nuclear recoil energy range of 6.6-30.5 keVnr are consistent with the background expectation of (1.0 \pm 0.2) events. A Profile Likelihood analysis using a 6.6-43.3 keVnr energy range sets the most stringent limit o…
Differences between Latin American and Spanish men in a batterer intervention programme: proximal and final outcomes
2020
El objetivo de este estudio es comprobar si existen diferencias en la efectividad de un programa de intervención para hombres condenados por violencia de género, en función del lugar de procedencia de los participantes (i.e., españoles e inmigrantes latinoamericanos). Se utilizó una muestra de 425 hombres penados por violencia de género que participaban en un programa estándar de intervención en España. Se consideraron como variables finales la reincidencia oficial y el riesgo de reincidencia y como variables proximales la intención de cambio, la asunción de responsabilidad, la adherencia al tratamiento y el compromiso con la intervención. No se encontraron diferencias entre participantes e…
Customer data collection infrastructure and Customer Experience Management:The SAQ Case Study
2017
Channel integration makes Customer Experience Management more complex and requires from retailers a regeneration of their value proposition. A longitudinal case study reveal a hierarchical sequence of operant resource triad: cultural mindsets, strategic directions for designing value propositions, and a dynamic system of capabilities for continually renewing customer experiences. The implementation of a customer data collection infrastructure, the adoption of an iterative and sequential innovation process, and the mobilization of cross-functional and multidisciplinary project teams, will help develop the firm’s dynamic system of capabilities.
Low doses of paclitaxel potently induce apoptosis in human retinoblastoma Y79 cells by up-regulating E2F1.
2008
Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses of PTX (5 nM) potently induce apoptosis in human retinoblastoma Y79 cells. The effect of PTX is accompanied by a potent induction of E2F1 which appears to play a critical role in the effects induced by PTX. PTX induced a dose- and time-dependent effect, with G2/M arrest, cyclines A, E and B1 accumulation and a marked modification in the status of Cdc2-cyclin B1 complex, the major player of the G2/M checkpoint. Apoptosis followed G2/M arrest. An early and prolonged increase in p53 expression with its stabilization by phosphorylation and acetylation and its nuclear …
Multiple modes of cell death in neuroendocrine tumors induced by artesunate.
2020
Abstract Background The paucity of effective treatment in neuroendocrine tumors (NETs) encouraged us to investigate the therapeutic value of artesunate (ART) promised by its inhibitory effect against various tumors and broad safety profile. Methods We evaluated the impact of ART on three NET cell lines, BON-1, QGP-1 and NCI-H727 on cellular and molecular levels. Results Our results showed that ART induced endoplasmic reticulum (ER) stress through phosphorylation of eIF2α, which further gave rise to autophagy in all three NET cell lines. Specifically, apoptosis and ferroptosis were also observed in BON-1 cells, which made BON-1 cell line more vulnerable upon ART treatment. The different sens…