Search results for "progressive"

Slowly progressive aphasia: a four-year follow-up study

2001

This paper reports the long-term follow-up of GC, a patient with primary progressive aphasia of the fluent type. GC presented at onset with an anomia characterized by sparing of first letter knowledge, that applied mainly to proper names and living categories. No semantic deficits were observed in the first stage of the disease, and MRI showed a left temporal lobe atrophy with a gradient from the pole to the posterior regions, the latter being less involved. We now report the clinical evolution of GC from the 2nd to the 4th year of disease. As the disease progressed, the anomia became more severe and the phenomenon of first letter sparing was no longer detectable. Also semantic knowledge wa…

Mental health perspectives of Hunter syndrome: Case reports of two biological siblings

2016

Hunter syndrome is a rare X-linked recessive disorder caused by deficiency of the lysosomal enzyme iduronate-2-sulphatase, leading to progressive accumulation of a substance called glycosaminoglycans in nearly all cell types, tissues, and organs. Hunter syndrome presents with facial dysmorphism, airway diseases, skeletal defects, cardiomyopathies, and neuropsychiatric manifestations. Mental subnormality is a cardinal feature in Hunter syndrome. This is a progressive cognitive decline that is not amenable to enzyme replacement therapy. Due to progressive cognitive decline, training the children to improve the adaptive functioning is a challenge that creates immense stress for the caregivers.…

Spanish validation of the Empirically Developed Clinical Staging Model (EmDe-5) for patients with bipolar disorder

2021

Abstract Introduction Bipolar disorder (BD) has been reconceptualised as a progressive disorder that develops from mild to severe presentations. An empirical staging model – the Empirically Developed Clinical Staging Model for BD (EmDe-5) – was developed in a previous study. This study aims to further validate that model using a larger and more representative Spanish sample. Material and methods 183 BD outpatients were recruited at 11 sites in Spain. Assessment included clinical characteristics of the BD (number of hospitalisations, number of suicide attempts, comorbid personality disorders), physical health (BMI, metabolic syndrome, number of physical illnesses), cognition (SCIP), function…

Clinical and Instrumental Findings and Disability Progression in Primary Progressive and Progressive Relapsing Multiple Sclerosis: A Comparison Study…

2013

Primary progressive crossed aphasia in dextrals: report of three cases

2013

Intravenous gammaglobulin treatment in chronic progressive multiple sclerosis

1998

BETWEEN PROGRESSIVISM AND INSTITUTIONALISM: ALBERT BENEDICT WOLFE ON EUGENICS

2013

Albeit concerned with the biological element in social evolution, Albert B. Wolfe was among the very few economists of the progressive era who openly expressed his concerns about certain implications of eugenic rhetoric for the social science. Specifically, Wolfe questioned the strong hereditary boundaries that more extreme eugenicists suggested about human beings. As I will attempt to show in paper, a careful examination of Wolfe’s writings reveals that his reaction was rooted in the belief that many of the social problems which eugenicists attributed to hereditary limitations, were actually imputable to the influence that the social, economic, and physical environment exercised on the ind…

On Simon Nelson Patten’s Progressivism: A note

2020

This article is an attempt to offer an assessment of the main coordinates of Simon Nelson Patten’s views on democracy and biological determinism. This will allow us to better delineate the differences—as well as the affinities—between Patten and the core of progressives discussed by Thomas C. Leonard in a series of path-breaking contributions, culminating in his Illiberal Reformers: Race, Eugenics, and American Economics in the Progressive Era. It is our contention that even within the persisting intricacies, ambiguities, and contradictions of Patten’s expository style, it is possible to trace a shift in some aspects of his ideas—a gradual evolution that makes his peculiar brand of progress…

Bioprogressive Paradigm in Physiotherapeutic and Antiaging Strategies: A Review

2018

This review updates the knowledge on the use of bioprogressive philosophy in current rehabilitation paradigms, focusing on age-related ailments and antiaging strategies. It is a holistic approach that combines aspects of biology and function into the realm of rehabilitation therapy. The bioprogressive philosophy, with assistance of modern technological developments, such as microgravity-producing devices and techniques, enables personalized and targeted therapeutic approach that seems the most effective in rehabilitation and prevention of neuro-myo-sensory disorders that compromise the homeostatic body harmony, particularly in old age. The review defines the aging, discusses the most common…

Vinorelbine plus cisplatin versus cisplatin plus vindesine and mitomycin C in stage IIIB-IV non-small cell lung carcinoma: a prospective randomized s…

2002

Abstract Purpose: To compare a regimen of vinorelbine and cisplatin (VC) to the combination of mitomycin, vindesine, and cisplatin (MVP) in patients with stage IIIB or stage IV non-small cell lung cancer (NSCLC). The main endpoits were analysis of objective response rates, toxicity, time to progression, and overall survival. Patients and methods: 247 eligible patients were randomized to receive (a) vinorelbine 25 mg/m 2 intravenous bolus on days 1and 8 plus cisplatin 100 mg/m 2 on day 1 every 4 weeks, or (b) mitomycin c 8 mg/m 2 i.v. on day 1, vindesine 3 mg/m 2 i.v. on days 1, 8, 15 and 22, plus cisplatin 100 mg/m 2 on day 1 every 4 weeks. In subsequent cycles vindesine was given every oth…