Search results for "proteomic"

The arbuscular mycorrhizal symbiosis a modulator of cadmium stress

2008

International audience; Ecosystems are submitted to various abiotic stresses, among which heavy metals represent major industrial pollutants. Cadmium (Cd), that has damaging effects on plant metabolism, occurs in agricultural environments through industrial pollution and human activities, including phosphate fertiliser and sewage sludge applications. Metal availability to plants can be modulated by soil microorganisms, such as arbuscular mycorrhizal (AM) fungi. In the present work, Cd effects on the model legume Medicago truncatula inoculated or not with the AM fungus Glomus intraradices have been studied at 3 levels: (1) plant biomass production together with green part chlorophyll quantif…

Differential expression proteomics to investigate responses and resistance to Orobanche crenata in legumes

2007

International audience; In order to study the plant response to parasitic plants and the molecular basis of the resistance we have used a proteomic approach. The root proteome of two accessions of the model legume Medicago truncatula and crop pea displaying differences in their resistance phenotype, in control as well as in infected plants have been compared. We report quantitative as well as qualitative differences in the two-dimensional gel electrophoresis (2-DE) maps between plant genotypes and treatments (control, non-infected, and infected). Differential spots spots were successfully identified by peptide mass fingerprinting (PMF) following MALDI-TOF mass spectrometry. Many of the prot…

Differential protein expression in cytokine-sensitive and -resistant pancreatic beta cell lines

2009

Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

2019

Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.

Letter to the Editor: Solution structure of hypothetical protein TA1414 from Thermoplasma acidophilum

2004

Evaluation of cellular response of breast cancer cells grown on distinctive collagen substrates

2008

Multi-omics analysis of epithelial-to mesenchymal transition mediators in breast cancer

2022

Metabolic Signature of Breast Cancer Patients Negative and Positive to 18F-FDG PET Srceening.

2011

Metabolic signature of breast cancer patients negative and positive to 18F-FDG PET screening.

2010

Breast cancer proteomics: from research to clinical applications.

2008

The exponentially increasing volume of information extracted from genomic and proteomic applications on cancer, while providing new insights into molecular composition of cancer cells and tissues, imposes new challenges on data rationalization as a tool for clinically relevant biomarker discovery. Breast cancer represents the most frequent and potentially aggressive type of cancer and, moreover, it is one of the most enigmatic and poorly predictable in its evolution, likely because it includes several different forms that behave differently among patients. Current clinical parameters for breast cancer diagnosis and cure are: tumour size, axillary lymph node status, histological grading and …