Search results for "psa"
showing 10 items of 286 documents
Prognostic value of nuclear matrix protein expression in localized prostate cancer.
2012
The aim of the study was to correlate nuclear matrix (NM) protein expression profiles with the risk of PSA progression or death in early prostate cancer (PCa).High-resolution two-dimensional gel electrophoresis (2D-PAGE) was used to identify tumor-associated NM proteins in the PCa specimens obtained from 94 patients. The association between the expression of each protein and the probability of PSA progression or death was studied through univariate analysis. Unsupervised hierarchical clustering analysis was then used to generate patient clusters showing comparable outcomes by including the proteins that were predictive at univariate analysis. PSA-free and overall survival curves relative to…
The role of the dentist in the diagnosis and management of patients with oral mucosal diseases
2021
Based on a few case reports of oral mucosal diseases a number of questions is raised about the role of dentists-general practitioners in the diagnostic procedure and management of patients with such diseases. For instance, are dentists prepared to prescribe topical corticosteroids and should dentists be taught how and when to take a biopsy? And how about palpation of the neck? A strong recommendation is made to take clinical pictures for proper documentation and, if needed, for telediagnostic procedures. Another issue relates to the communication between dentists and dental specialists when dealing with patients with oral diseases. In case of a patient suffering from burning mouth syndrome …
Prostatas vēža preventīvie pasākumi stacionārā
2016
Darba tēma - Prostatas vēža preventīvie pasākumi stacionārā. Mērķis: Analizēt pacientu izglītošanu par prostatas vēža preventīviem pasākumiem stacionārā māsu un pacientu skatījumā.. Uzdevumi: Veikt literatūras analīzi par prostatas vēzi, saistīt D. Džonsones māszinību teoriju ar prostatas vēža preventīviem pasākumiem, analizēt prostatas vēža preventīvos pasākumus, izstrādāt darba instrumentu, aptaujas anketas māsām un pacientiem, veikt iegūto rezultātu apkopošanu un analīzi, izstradāt secinājumus un ieteikumus Hipotēze: Ja māsai un pacientam ir laba sadarbība izglītošanā par prostatas vēža preventīviem pasākumiem, tad pacienti zina par PSA analīzes nepieciešamību. Instruments: aptaujas anke…
Correlazione tra dosaggio di paratormone ed elevati valori di PSA prebioptici in pazienti con successivo esito istologico di benignità
2012
The functional relationship between parathyroid glands and prostatic gland is commonly very well known. The aim of our study was to investigate the relationship between serum levels of PTH and serum levels of PSA in patients with pathological finding of BPH. According to 261 transrectal ultra- sound-guided prostatic biopsies performed from March 2009 to March 2010, 75 patients, responding to our inclusion criteria, were selected. 26 patients (34.6%) ended the study. All patients with high serum levels of PSA (>4 ng/mL), with histological diagnosis of benign prostatic hyperplasia, underwent the assay of serum levels of PTH. We observed high levels of PTH (> 66 pg/mL) in 9 patients (35.2%)
Hormonrefraktāra prostatas vēža terapijas iespējas
2015
Aktualitāte: Pēdējās desmitgades laikā būtiski mainījusies pieeja hormonrefraktāra (HRPV) prostatas vēža terapijā. Kaut arī atrasti jauni preparāti HRPV ārstēšanā. Darba uzdevums: Analizēt pacienta stāvokli pie hormonālās refraktaritātes, hormonālās terapijas blakus efektus un kā arī slimības prognostiskos faktorus. Materiāls un metodes: Retrospektīvā pētījumā tika iekļauti 46 pacienti un telefona intervijā bijā. Rezultāti. Pētījuma pacientu vidējais vecums bija 74 gadi (SD +5,5). Vidējais laiks līdz hormonālai refraktaritātei bija 1,5 gadi (SD +2). 65,2% pacientiem vidējais PSA bija >10, kas liecina par prognostiski sliktu slimības gaitu, Vislabākā prognoze tika novērota 10,9% pacientiem a…
Prostatas biopsijas ar attēlu sapludināšanas metodi rezultātu analīze atkarībā no prostatas tilpuma, PSA un PSA blīvuma
2021
Prostatas vēzis ir visbiežāk diagnosticētais ļaundabīgais audzējs visā pasaulē. Dažādos avotos kā nāves cēlonis tas svārstās no ceturtās līdz sestajai vietai. Lielāko daļu pacientu sastāda lēni augoši, mazagresīvi audzēji. Sākuma stadijās prostatas audzējs ir asimptomātiksks, Diagnoze galvenokārt balstās uz prostatas specifiskā antigēna (PSA) testēšanu un ar transrektālu ultraskaņu vadītu (TRUS) prostatas audu biopsiju. Avoti gan liecina, ka skrīninga PSA testēšana joprojām nav gana sensitīva diagnostiskā metode. Mērķis: Zinātniskā pētījuma mērķis ir atrast, kādi faktori ietekmē indikācijas attēlu sapludināšanas biopsijai un kādi faktori ietekmē pozitīvu attēlu sapludināšanas biopsiju prost…
New scenarios for neuronal structural plasticity in non-neurogenic brain parenchyma: the case of cortical layer II immature neurons
2011
The mammalian central nervous system, due to its interaction with the environment, must be endowed with plasticity. Conversely, the nervous tissue must be substantially static to ensure connectional invariability. Structural plasticity can be viewed as a compromise between these requirements. In adult mammals, brain structural plasticity is strongly reduced with respect to other animal groups in the phylogenetic tree. It persists under different forms, which mainly consist of remodeling of neuronal shape and connectivity, and, to a lesser extent, the production of new neurons. Adult neurogenesis is mainly restricted within two neurogenic niches, yet some gliogenic and neurogenic processes a…
Capsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats
2005
It is discussed whether capsaicin, an agonist of the pain mediating TRPV1 receptor, decreases or increases voltage-activated calcium channel (VACC) currents (ICa(V)). ICa(V) were isolated in cultured dorsal root ganglion (DRG) neurones of rats using the whole cell patch clamp method and Ba 2+ as charge carrier. In large diameter neurones (>35Am), a concentration of 50AM was needed to reduce ICa(V) (activated by depolarizations to 0 mV) by 80%, while in small diameter neurones (30Am), the IC50 was 0.36 AM. This effect was concentration dependent with a threshold below 0.025 AM and maximal blockade (>80%) at 5AM. The current–voltage relation was shifted to the hyperpolarized direction with an…
Psammous desmo-osteoblastoma
1987
Fibro-osteo-cemental lesions of the jaw bones are a heterogeneous group of diseases which present problems in classification. Psammous desmo-osteoblastoma is one of four newly proposed entities (Makek 1983) and has until now been characterized by its light microscopic, clinical and radiological features. On electron microscopy this tumour exhibits fibroblastic (preosteoblastic), osteoblastic and osteocytic cells and a globular mineralization unlike the mineralization of the psammoma bodies. Immunohistological investigations with anti-osteonectin, a bone specific protein linking mineral to collagen, showed positive intracellular staining in all tumour cells and extracellular staining in the …
Psammomatous malignant melanoma arising in an intradermal naevus
2001
Psammomatous malignant melanoma arising in an intradermal naevus Aims: A wide variety of differentiation patterns may be found in malignant melanoma. Schwannian features are unusual, and mostly present in the desmoplastic variant. We report the first description of psammoma bodies in malignant melanoma. Methods and results: A malignant melanoma arose in an intradermal naevus of the scalp in a 51-year-old woman, displaying focal neural-like features in the form of rosette-like pseudo-meissnerian alveolar nests, as well as numerous psammoma bodies grouped in a few areas. Tumour cell immunostaining for S100, HMB45, NKI-C3, and vimentin was detected. In addition, both malignant and benign melan…