Search results for "psychosi"
showing 10 items of 330 documents
'At risk mental state' clinics for psychosis - An idea whose time has come - And gone!
2019
AbstractAt Risk Mental State (ARMS) clinics are specialised mental health services for young, help-seeking people, thought to be at ultra-high risk of developing psychosis. Their stated purpose is to reduce transitions from the ARMS state to clinical psychotic disorder. Reports of ARMS clinics provide ‘evidence-based recommendations’ or ‘guidance’ for the treatment of such individuals, and claim that such clinics prevent the development of psychosis. However, we note that in an area with a very well-developed ARMS clinic (South London), only a very small proportion (4%) of patients with first episode psychosis had previously been seen at this clinic with symptoms of the ARMS. We conclude th…
ADDITIVE INTERACTION BETWEEN LIFETIME CANNABIS USE AND CHILDHOOD TRAUMA IN INCREASING THE RISK FOR PSYCHOSIS. A REPLICATION ANALYSIS ON A SAMPLE OF F…
2012
Background: Additive interaction between childhood trauma and cannabis use in increasing risk for psychotic disorders has been recently demonstrated in a prospective (Harley et al., 2009) and a cross sectional study (Konigs et al., 2011), although not replicated in another survey (Kuepper et al., 2011). This study aimed to analyse additive interaction between lifetime cannabis and severe child abuse in increasing the risk for psychosis in a sample of first episode psychosis patients and geographically matched controls. In addition, analyses were re-run separately for males and females in order to investigate whether the association was moderated by gender. Methods: The sample consisted of 2…
Cumulative social disadvantage and psychosis: findings from a southern Italy case-control study
2016
Aim: There are consistent evidence suggesting that psychotic disorders are associated to social disadvantage and isolation in adulthood, and research suggested that they these are not simply a consequence of the functional impairment related to onset of the disease (Stilo et al., 2013; Morgan et al., 2008). To date only a few studies have investigated the impact of social risk factors on psychosis in Italy. This study aimed to replicate existing findings in a case-control sample from Southern Italy. Methods: 134 individuals presenting for the first time to mental health services of Palermo (Italy) with an ICD 10 diagnosis of psychosis and 175 population controls from Palermo (Italy) were en…
"Issues like this have an impact" : the need-adapted treatment of psychosis and the psychiatrist's inner dialogue
2014
ReMindCare App for Early Psychosis: Pragmatic Real World Intervention and Usability Study
2020
Background: eHealth interventions are widely used in clinical trials and increasingly in care settings as well; however, their efficacy in real-world contexts remains unknown. ReMindCare is a smartphone app that has been systematically implemented in a first episode of psychosis program (FEPP) for patients with early psychosis since 2018. Objective: The objective of this study was to assess the efficacy of ReMindCare after 19 months of use in the clinic and varying use by individual patients. Methods: The integration of the ReMindCare app into the FEPP started in October 2018. Patients with early psychosis self-selected to the app (ReMindCare group) or treatment as usual (TAU group). The ou…
Systematic review and exploratory meta-analysis of the efficacy, safety, and biological effects of psychostimulants and atomoxetine in patients with …
2019
ObjectiveOur aim was to summarize the efficacy and safety of atomoxetine, amphetamines, and methylphenidate in schizophrenia.MethodsWe undertook a systematic review, searching PubMed/Scopus/Clinicaltrials.gov for double-blind, randomized, placebo-controlled studies of psychostimulants or atomoxetine in schizophrenia published up to 1 January 2017. A meta-analysis of outcomes reported in two or more studies is presented.ResultsWe included 22 studies investigating therapeutic effects of stimulants (k=14) or measuring symptomatic worsening/relapse prediction after stimulant challenge (k=6). Six studies of these two groups plus one additional study investigated biological effects of psychostimu…
Bridging the gap between research into biological and psychosocial models of psychosis.
2015
Paul Bebbington's recent Special Article provides an excellent synthesis of recent advances in psychosocial research on psychosis. However, we doubt that a model based solely on social epidemiology and cognitive theory can totally describe psychosis, and to be fair, Bebbington does not suggest that it does. A complete model must also incorporate what we have learned from non-social epidemiology, neuroscience, and genetics. Evidence indicates that both the social risk factors that interest Bebbington and biological risk factors, such as abuse of stimulants and cannabis, can provoke psychotic symptoms by dysregulating striatal dopamine. The role of neurodevelopmental deviance also needs to be…
"Kirjoittaminen on tie minuun, minusta sinuun" : ryhmämuotoinen kirjoittaminen ja metaforien merkitys psykoosia sairastavien kirjallisuusterapiassa
2015
This is a study on the significance of group poetry therapy and the use of metaphors by people diagnosed with psychosis. The data includes seven client interviews, poems and other texts written in the poetry therapy sessions, and my research diary; it was collected from a group I personally directed for one year. The research aimed to answer these questions: 1) what are the most meaningful and therapeutic aspects in group poetry therapy from the point of view of the client? 2) What is the per- sonal significance of therapeutic metaphor and poetic language for people who experience psychosis? 3) What kind of poetry therapy model is suitable for people with schizophrenia and other psychose…
BIOLOGICAL AND EPIDEMIOLOGICAL EXAMINATION OF TRANSDIAGNOSTIC AND SPECIFIC SYMPTOM DIMENSIONS AT PSYCHOSIS ONSET: FINDINGS FROM THE EUGEI STUDY
2018
Background Current diagnostic models of psychosis have been questioned since Kraepelin’s original dichotomy of dementia praecox and manic depression. Indeed, increasing evidence has suggested that a dimensional approach might be a valid alternative platform for research. However, while an increasing number of studies have investigated how environmental risk factors for affective and non-affective psychosis map onto symptom dimensions, only a few have examined these dimensions in relation to genetic variants as summarised by Polygenic Risk Score (PRS). Furthermore, no studies have examined the putative effect of PRS for Schizophrenia (SZ), Bipolar Disorder (BP), and Major Depressive Disorder…