Search results for "puberty"

DOWN REGULATION OF LYMPHOCYTES APOPTOSIS IN GIRLS WITH PRECOCIOUS PUBERTY

2011

The effects of sexual hormones secretion in children with precocious puberty induce significant somatic and psychological changes, with systemic implications on several organs and tissues. Besides immune system and blood cells are involved in these changes. Recent studies on mice lymphocytes have demonstrated a protection of estrogens against apoptosis Fas-FasL pathway. These data could partially elucidate why autoimmune diseases are more frequent in females adolescents, whereas males have higher mortality associated with infectious diseases. We studied ten girls (age: 4-7 years) affected by idiopathic precocious puberty, with pubertal stage B3-PH3-4. All presented increased bone age/chrono…

CD 95 and TRAIL induced lymphocytes apoptosis in girls with precocious puberty.

2008

Growth patterns at distal radius and tibial shaft in pubertal girls: a 2-year longitudinal study.

2005

Bone changes, in terms of both size and BMD, were assessed longitudinally in pubertal girls. Before puberty, BMD at the distal radius declined, whereas bone size increased, suggesting that normal growing girls experience a transient period of increased bone fragility. This could explain the elevated low-trauma forearm fracture rates reported in earlier studies. Introduction: Longitudinal data on bone growth during puberty are sparse. Such information is needed to understand the sequence of biological changes, the physical and mechanical consequences for the growing skeleton, and the implications for later life. Materials and Methods: The geometric properties and volumetric BMD (vBMD) of the…

Efectos del ácido valproico sobre el desarrollo sexual

2003

Introducción: La utilización del ácido valproico se ha relacionado enniñas y adolescentes con efectos adversos endocrinológicos: ganancia de peso e hiperandrogenismo. Además, enmujeres adultas se han descrito ovarios poliquísticos e hiperinsulinismo. En varones apenas se han estudiado losposibles efectos adversos endocrinológicos. Objetivos: El objetivo de este estudio fue evaluar los efectos del ácido valproico en el desarrollo puberal en chicas y en chicosepilépticos, en especial relación con su posible efecto hiperandrogénico. Material y métodos: Se incluyeron 23 chicas y 15 chicos (entre 8 y 16 años)epilépticos, tratados con ácido valproico, se compararoncon 15 niñas control y 10 niños …

Prospective analysis of the influence of sport and educational factors on the prevalence and initiation of smoking in older adolescents from Croatia

2017

The prevalence of smoking among Croatian adolescents is alarmingly high, but no previous study has prospectively examined the sport- and academic-factors associated with smoking and smoking initiation. This study aimed to prospectively examine the associations between scholastic (educational) achievement and sport factors and smoking in 16- to 18-year-old adolescents. This two-year prospective cohort study included 644 adolescents who were 16 years of age at baseline (46% females). Baseline testing was implemented at the beginning of the 3rd year of high school (September 2014) when participants were 16 years old. Follow-up testing was completed at the end of the fourth year of high school,…

Longitudinal associations of physical activity and pubertal development with academic achievement in adolescents.

2020

Highlights • Boys with higher levels of moderate-to-vigorous physical activity had better academic achievement than those with lower levels of physical activity at baseline. • Physical activity was not associated with academic achievement at follow-up in boys or girls. • Continuously inactive adolescents had poorer academic achievement over the follow-up period than their more active peers. • Girls with more advanced pubertal status had better academic achievement than other girls.

Differenzierung zwischen prämaturer Thelarche und Pubertas praecox anhand klinischer, hormoneller und radiologischer Befunde

2008

In a retrospective study of 39 girls (aged 10 months to 7 10/12 years) with premature breast development criteria for distinguishing between premature thelarche and precocious puberty were analysed. Serum estradiol levels and bone age were determined and a test with luteinizing hormone-releasing hormone (LHRH) performed (inclusion criteria). On the basis of the LHRH test and bone age, premature thelarche was diagnosed in 29 patients and precocious puberty in ten: while those with premature thelarche had a follicle-stimulating hormone (FSH) pattern of rise, in those with precocious puberty the rise in gonadotropin was of the LH type. The LH/FSH ratio 30 min after stimulation was 1 (median 2.…

Clinical and metabolic findings in a 6-year-old boy with a Leydig cell tumour

2011

Aim:  To analyse the urinary steroid metabolome in a boy who had true precocious puberty after a Leydig cell tumour. Method:  Case report and detailed description of clinical and metabolic findings in a 7-year-old-boy with a Leydig cell tumour. Results:  Before surgery, the urinary steroid metabolome showed an activation of an alternative route to gonadal androgens independent of dehydroepiandrosterone (DHEA). After surgery, the boy entered true precocious puberty. Under leuprolide acetate treatment, clinical and laboratory findings normalized. Conclusion:  Central precocious puberty after precocious pseudopuberty may be more common than expected and should be considered in children with pe…

Cognitive consequences of the timing of puberty

2018

In this paper, we use British cohort data to study the degree to which children at different stages of pubertal development at age 11 and 16 differ in their cognitive and behavioral outcomes at age 16 as well as in their completed educational attainment and adult earnings. Controlling for age 7 cognitive skills, region of birth, father's socioeconomic status and parents’ education, we show that boys’ late pubertal development is associated with lower levels of cognitive skills at 16, lower final educational attainment, and lower earnings in adulthood. For girls we find a similar negative relationship between late puberty and cognitive skills, but only imprecise relationships between the tim…

The timing of puberty and gender differences in educational achievement

2017

In this paper, we study the effect of the timing of puberty on educational achievement and examine to what extent the gender differences in the timing of puberty can explain gender differences in achievement. We use British cohort data that combine information on pubertal development with test scores, behavioral outcomes as well as final educational attainment and earnings. Controlling for age 7 cognitive skills and family background, we show that late pubertal development is associated with a slower rate of cognitive skill growth during adolescence. This disadvantage in cognitive development is also reflected in lower levels of educational attainment and earnings for late developed individ…