Search results for "quinoxaline"
showing 10 items of 91 documents
CCDC 157964: Experimental Crystal Structure Determination
2001
Related Article: P.J.Skabara, R.Berridge, K.Prescott, L.M.Goldenberg, E.Orti, R.Viruela, R.Pou-Amerigo, A.S.Batsanov, J.A.K.Howard, S.J.Coles, M.B.Hursthouse|2000|J.Mater.Chem.|10|2448|doi:10.1039/b003910l
CCDC 650800: Experimental Crystal Structure Determination
2008
Related Article: C.Yuste, A.Bentama, S.-E.Stiriba, D.Armentano, G.De Munno, F.Lloret, M.Julve|2007|Dalton Trans.||5190|doi:10.1039/b709233d
CCDC 883546: Experimental Crystal Structure Determination
2012
Related Article: J.Vallejo, J.Cano, I.Castro, M.Julve, F.Lloret, O.Fabelo, L.Canadillas-Delgado, E.Pardo|2012|Chem.Commun.|48|7726|doi:10.1039/c2cc33674j
CCDC 880437: Experimental Crystal Structure Determination
2013
Related Article: P.Albores, C.Plenk, E.Rentschler|2012|Inorg.Chem.|51|8373|doi:10.1021/ic300911j
Spin crossover in six-coordinate [Fe(L)2(NCX)2] compounds with L = DPQ = 2,3-bis-(2′-pyridyl)-quinoxaline, ABPT = 4-amino-3,5-bis(pyridin-2-yl)-1,2,4…
1998
[EN] The iron(II) compounds of formulae [Fe(DPQ)2(NCS)2]·CO(CH)3)2(DPQ = 2,3-bis-(2¿-pyridyl)-quinoxaline) (1) and [Fe(ABPT)2-(NCX)2] (ABPT = 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole) X = S (2) and Se (3) were synthesized and the crystal structure of 1 determined by X-ray diffraction methods. It crystallizes in the monoclinic system . The structure is made up of discrete [Fe(DPQ)2(NCS)2] units. Each metal atom is in a distorted FeN6 octahedral environment, the Fe¿N bonds ranging from 2.013(8) Å to 2.425(8) Å. Variable-temperature magnetic susceptibility data in the temperature range 290¿4.2 K revealed that 1 is high spin, in contrast to 2 and 3 which show a moderately cooperative high s…
Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action
2015
Abstract Water-soluble isoindoloquinoxalin (IIQ) imines and the corresponding acetates were conveniently prepared from the key intermediates 2-(2′-aminophenyl)-2H-isoindole-1-carbonitriles obtained by a Strecker reaction between substituted 1,2-dicarbaldehydes and 1,2-phenylenediamines. Both series were screened by the National Cancer Institute (Bethesda, MD) and showed potent antiproliferative activity against a panel of 60 human tumor cell lines. Several of the novel compounds showed GI50 values at a nanomolar level on the majority of the tested cell lines. Among IIQ derivatives, methoxy substituents at positions 3 and 8 or/and 9 were especially effective in impairing cell cycle progressi…
Assessing the reactivity of sodium alkyl-magnesiates towards quinoxaline : single electron transfer (SET) vs. nucleophilic alkylation processes
2015
By exploring the reactivity of sodium butyl-magnesiate (1) supported by the bulky chelating silyl(bisamido) ligand {Ph2Si(NAr*)2}(2-) (Ar* = 2,6-iPr2-C6H3) towards Quinoxaline (Qx), the ability of this bimetallic system to effectively promote SET processes has been disclosed. Thus 1 executes the single-electron reduction of Qx affording complex (2) whose structure in the solid state contains two quinaxolyl radical anions Qx˙ stabilised within a dimeric magnesiate framework. Combining multinuclear NMR and EPR measurements with DFT calculations, new insights into the constitution of 2 in solution and its magnetic behaviour have been gained. Further evidence on the SET reactivity of 1 was foun…
SYNTHESIS OF TETRACYCLIC SYSTEMS WITH POTENT ANTITUMOR ACTIVITY
2011
Inhibitory influence of chromogranin A N-terminal fragment (vasostatin-1) on the spontaneous contractions of rat proximal colon
2005
Very little is known about the role played by CGA and its fragments in the gastrointestinal physiology. We have studied the role of CGA N-terminal fragments in the regulation of intestinal smooth muscle contractility by measuring the influence of recombinant CGA 1-78 (VS-1) and synthetic CGA 7-57 peptides on the spontaneous mechanical activity of rat proximal colon in vitro. The mechanical activity was recorded as changes in the intraluminal pressure. VS-1 (0.1-30 nM) and CGA 7-57 (10-300 nM) produced concentration-dependent inhibitory effects, characterized by a progressive decrease in the mean amplitude of circular muscle spontaneous contractions, without affecting the resting tone. The r…
CCDC 880438: Experimental Crystal Structure Determination
2013
Related Article: P.Albores, C.Plenk, E.Rentschler|2012|Inorg.Chem.|51|8373|doi:10.1021/ic300911j