Search results for "radical"
showing 10 items of 1401 documents
Intermolecular oxidative dehydrogenative 3,3′-coupling of benzo[b]furans and benzo[b]thiophenes promoted by DDQ/H+: total synthesis of shandougenine B
2016
With an excess of a strong acid, 2,3-dichloro-5,6-dicyano-1,4-quinone (DDQ) is shown to promote metal-free intermolecular oxidative dehydrogenative (ODH) 3,3'-coupling of 2-aryl-benzo[b]furans and 2-aryl-benzo[b]thiophenes up to 92% yield as demonstrated with 9 substrates. Based on the analysis of oxidation potentials and molecular orbitals combined with EPR, NMR and UV-Vis observations, the studied reaction is initiated by a DDQ-substrate charge transfer complex and presumably proceeds via oxidation of the substrate into an electrophilic radical cation that further reacts with another molecule of a neutral substrate. The coupling reactivity can easily be predicted from the oxidation potent…
Synthesis, Stability and Relaxivity of TEEPO-Met: An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging
2018
Cancer is a widespread and life-threatening disease and its early-stage diagnosis is vital. One of the most effective, non-invasive tools in medical diagnostics is magnetic resonance imaging (MRI) with the aid of contrast agents. Contrast agents that are currently in clinical use contain metals, causing some restrictions in their use. Also, these contrast agents are mainly non-specific without any tissue targeting capabilities. Subsequently, the interest has notably increased in the research of organic, metal-free contrast agents. This study presents a new, stable organic radical, TEEPO-Met, where a radical moiety 2,2,6,6-tetraethylpiperidinoxide (TEEPO) is attached to an amino acid, methio…
Radical sex role ideology and the Finnish gender role movement in the late 1960s
2022
An active discussion of gender roles and the need to renegotiate them took place in the late 1960s in Finland. While previous studies have associated this ‘sex role debate’ with the independent civic organisation Association 9, this article focuses on the wider gender role movement. The article analyses the interplay and differences among the Finnish Women’s Democratic League, the Committee for Women’s Status, and Association 9’s grassroots activism between 1965 and 1970. It demonstrates that similar ideas about sex roles were presented simultaneously in two public spheres: the dominant public, where the ideas were promoted by Association 9, and the people’s democratic counterpublic, which …
CCDC 2097024: Experimental Crystal Structure Determination
2021
Related Article: Anni I. Taponen, Awatef Ayadi, Manu K. Lahtinen, Itziar Oyarzabal, Sébastien Bonhommeau, Mathieu Rouzières, Corine Mathonière, Heikki M. Tuononen, Rodolphe Clérac, Aaron Mailman|2021|J.Am.Chem.Soc.|143|15912|doi:10.1021/jacs.1c07468
CCDC 2097023: Experimental Crystal Structure Determination
2021
Related Article: Anni I. Taponen, Awatef Ayadi, Manu K. Lahtinen, Itziar Oyarzabal, Sébastien Bonhommeau, Mathieu Rouzières, Corine Mathonière, Heikki M. Tuononen, Rodolphe Clérac, Aaron Mailman|2021|J.Am.Chem.Soc.|143|15912|doi:10.1021/jacs.1c07468
Nanoparticles of a polyaspartamide-based brush copolymer for modified release of sorafenib: In vitro and in vivo evaluation.
2017
Abstract In this paper, we describe the preparation of polymeric nanoparticles (NPs) loaded with sorafenib for the treatment of hepatocellular carcinoma (HCC). A synthetic brush copolymer, named PHEA-BIB-ButMA (PBB), was synthesized by Atom Trasnfer Radical Polymerization (ATRP) starting from the α-poly( N -2-hydroxyethyl)- d , l -aspartamide (PHEA) and poly butyl methacrylate (ButMA). Empty and sorafenib loaded PBB NPs were, then, produced by using a dialysis method and showed spherical morphology, colloidal size, negative ζ potential and the ability to allow a sustained sorafenib release in physiological environment. Sorafenib loaded PBB NPs were tested in vitro on HCC cells in order to e…
The Two Dimensions of Narcissistic Personality and Support for the Radical Right: The Role of Right–Wing Authoritarianism, Social Dominance Orientati…
2020
This paper offers an explanation of the link between grandiose narcissism and support for radical right parties. Drawing on representative data of the GESIS Panel ( N = 2827), focusing on support for the German radical right populist party Alternative for Germany in 2016 and treating grandiose narcissism as a two–dimensional concept, it is shown that the effects of grandiose narcissism are indirect rather than direct. The paper also reveals that it is mainly narcissistic rivalry that accounts for radical right party support, whereas narcissistic admiration has a protecting relationship. Finally, our results indicate that the indirect effects of narcissistic rivalry on radical right party s…
CCDC 1834563: Experimental Crystal Structure Determination
2018
Related Article: Serhii Krykun, Vincent Croué, Magali Allain, Zoia Voitenko, Juan Aragó, Enrique Ortí, Sébastien Goeb, Marc Sallé|2018|J.Mater.Chem.C|6|13190|doi:10.1039/C8TC04730H
CCDC 2182459: Experimental Crystal Structure Determination
2022
Related Article: Anni I. Taponen, Awatef Ayadi, Noora Svahn, Manu K. Lahtinen, Mathieu Rouzières, Rodolphe Clérac, Heikki M. Tuononen, Aaron Mailman|2022|Cryst.Growth Des.|22|7110|doi:10.1021/acs.cgd.2c00795
CCDC 1863394: Experimental Crystal Structure Determination
2018
Related Article: Anni I. Taponen, Joanne W. L. Wong, Kristina Lekin, Abdeljalil Assoud, Craig M. Robertson, Manu Lahtinen, Rodolphe Clérac, Heikki M. Tuononen, Aaron Mailman, Richard T. Oakley|2018|Inorg.Chem.|57|13901|doi:10.1021/acs.inorgchem.8b02416